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Non-genetic determinants of malignant clonal fitness at single-cell resolution
Fennell, Katie A., Vassiliadis, Dane, Lam, Enid Y. N., Martelotto, Luciano G., Balic, Jesse J., Hollizeck, Sebastian, Weber, Tom S., Semple, Timothy, Wang, Qing, Miles, Denise C., MacPherson, Laura, Chan, Yih-Chih, Guirguis, Andrew A., Kats, Lev M., Wong, Emily S., Dawson, Sarah-Jane, Naik, Shalin H., Dawson, Mark A.
Published in Nature (London) (06.01.2022)
Published in Nature (London) (06.01.2022)
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Journal Article
Click chemistry enables preclinical evaluation of targeted epigenetic therapies
Tyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, MacPherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola, Dawson, Mark A.
Published in Science (American Association for the Advancement of Science) (30.06.2017)
Published in Science (American Association for the Advancement of Science) (30.06.2017)
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Journal Article
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
Sparbier, Christina E., Gillespie, Andrea, Gomez, Juliana, Kumari, Nishi, Motazedian, Ali, Chan, Kah Lok, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Popp, Sarah, Gough, Daniel J., Eckersley-Maslin, Melanie A., Dawson, Sarah-Jane, Lehner, Paul J., Sutherland, Kate D., Ernst, Patricia, McGeehan, Gerard M., Lam, Enid Y. N., Burr, Marian L., Dawson, Mark A.
Published in Nature cell biology (01.02.2023)
Published in Nature cell biology (01.02.2023)
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Journal Article
An Erg-driven transcriptional program controls B cell lymphopoiesis
Ng, Ashley P., Coughlan, Hannah D., Hediyeh-zadeh, Soroor, Behrens, Kira, Johanson, Timothy M., Low, Michael Sze Yuan, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Kueh, Andrew J., Boudier, Thomas, Feltham, Rebecca, Gabrielyan, Anna, DiRago, Ladina, Hyland, Craig D., Ierino, Helen, Mifsud, Sandra, Viney, Elizabeth, Willson, Tracy, Dawson, Mark A., Allan, Rhys S., Herold, Marco J., Rogers, Kelly, Tarlinton, David M., Smyth, Gordon K., Davis, Melissa J., Nutt, Stephen L., Alexander, Warren S.
Published in Nature communications (15.06.2020)
Published in Nature communications (15.06.2020)
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Journal Article
Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
Yeh, Paul, Hunter, Tane, Sinha, Devbarna, Ftouni, Sarah, Wallach, Elise, Jiang, Damian, Chan, Yih-Chih, Wong, Stephen Q., Silva, Maria Joao, Vedururu, Ravikiran, Doig, Kenneth, Lam, Enid, Arnau, Gisela Mir, Semple, Timothy, Wall, Meaghan, Zivanovic, Andjelija, Agarwal, Rishu, Petrone, Pasquale, Jones, Kate, Westerman, David, Blombery, Piers, Seymour, John F., Papenfuss, Anthony T., Dawson, Mark A., Tam, Constantine S., Dawson, Sarah-Jane
Published in Nature communications (17.03.2017)
Published in Nature communications (17.03.2017)
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Journal Article
“Auto-anti-IgE”: Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation
Chan, Yih-Chih, Ramadani, Faruk, Santos, Alexandra F., Pillai, Prathap, Ohm-Laursen, Line, Harper, Clare E., Fang, Cailong, Dodev, Tihomir S., Wu, Shih-Ying, Ying, Sun, Corrigan, Christopher J., Gould, Hannah J.
Published in Journal of allergy and clinical immunology (01.12.2014)
Published in Journal of allergy and clinical immunology (01.12.2014)
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Journal Article
Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
Chen, Jiun-Bo, James, Louisa K., Davies, Anna M., Wu, Yu-Chang Bryan, Rimmer, Joanne, Lund, Valerie J., Chen, Jou-Han, McDonnell, James M., Chan, Yih-Chih, Hutchins, George H., Chang, Tse Wen, Sutton, Brian J., Kariyawasam, Harsha H., Gould, Hannah J.
Published in Journal of allergy and clinical immunology (01.04.2017)
Published in Journal of allergy and clinical immunology (01.04.2017)
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Journal Article
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
He, Michael Y., Halford, Michael M., Liu, Ruofei, Roy, James P., Grant, Zoe L., Coultas, Leigh, Thio, Niko, Gilan, Omer, Chan, Yih-Chih, Dawson, Mark A., Achen, Marc G., Stacker, Steven A.
Published in Communications biology (15.07.2021)
Published in Communications biology (15.07.2021)
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Journal Article
Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients
Pillai, Prathap, Fang, Cailong, Chan, Yih-Chih, Shamji, Mohamed H., Harper, Clare, Wu, Shih-Ying, Ohm-Laursen, Line, Durham, Stephen R., Menzies-Gow, Andrew, Rajakulasingam, Raj K., Ying, Sun, Corrigan, Chris J., Gould, Hannah J.
Published in Journal of allergy and clinical immunology (01.06.2014)
Published in Journal of allergy and clinical immunology (01.06.2014)
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Journal Article
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Burr, Marian L., Sparbier, Christina E., Chan, Yih-Chih, Williamson, James C., Woods, Katherine, Beavis, Paul A., Lam, Enid Y. N., Henderson, Melissa A., Bell, Charles C., Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W., Bassik, Michael C., Neeson, Paul J., Behren, Andreas, Darcy, Phillip K., Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A., Cebon, Jonathan, Lehner, Paul J., Dawson, Mark A.
Published in Nature (London) (07.09.2017)
Published in Nature (London) (07.09.2017)
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Journal Article
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D., Dawson, Mark A.
Published in Cancer cell (14.10.2019)
Published in Cancer cell (14.10.2019)
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Journal Article
Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
Agarwal, Rishu, Chan, Yih-Chih, Tam, Constantine S., Hunter, Tane, Vassiliadis, Dane, Teh, Charis E., Thijssen, Rachel, Yeh, Paul, Wong, Stephen Q., Ftouni, Sarah, Lam, Enid Y. N., Anderson, Mary Ann, Pott, Christiane, Gilan, Omer, Bell, Charles C., Knezevic, Kathy, Blombery, Piers, Rayeroux, Kathleen, Zordan, Adrian, Li, Jason, Huang, David C. S., Wall, Meaghan, Seymour, John F., Gray, Daniel H. D., Roberts, Andrew W., Dawson, Mark A., Dawson, Sarah-Jane
Published in Nature medicine (01.01.2019)
Published in Nature medicine (01.01.2019)
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Journal Article
HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, Laura, Anokye, Juliana, Yeung, Miriam M., Lam, Enid Y. N., Chan, Yih-Chih, Weng, Chen-Fang, Yeh, Paul, Knezevic, Kathy, Butler, Miriam S., Hoegl, Annabelle, Chan, Kah-Lok, Burr, Marian L., Gearing, Linden J., Willson, Tracy, Liu, Joy, Choi, Jarny, Yang, Yuqing, Bilardi, Rebecca A., Falk, Hendrik, Nguyen, Nghi, Stupple, Paul A., Peat, Thomas S., Zhang, Ming, de Silva, Melanie, Carrasco-Pozo, Catalina, Avery, Vicky M., Khoo, Poh Sim, Dolezal, Olan, Dennis, Matthew L., Nuttall, Stewart, Surjadi, Regina, Newman, Janet, Ren, Bin, Leaver, David J., Sun, Yuxin, Baell, Jonathan B., Dovey, Oliver, Vassiliou, George S., Grebien, Florian, Dawson, Sarah-Jane, Street, Ian P., Monahan, Brendon J., Burns, Christopher J., Choudhary, Chunaram, Blewitt, Marnie E., Voss, Anne K., Thomas, Tim, Dawson, Mark A.
Published in Nature (London) (09.01.2020)
Published in Nature (London) (09.01.2020)
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Journal Article
Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Guirguis, Andrew A., Ofir-Rosenfeld, Yaara, Knezevic, Kathy, Blackaby, Wesley, Hardick, David, Chan, Yih-Chih, Motazedian, Ali, Gillespie, Andrea, Vassiliadis, Dane, Lam, Enid Y.N., Tran, Kevin, Andrews, Byron, Harbour, Michael E., Vasiliauskaite, Lina, Saunders, Claire J., Tsagkogeorga, Georgia, Azevedo, Aleksandra, Obacz, Joanna, Pilka, Ewa S., Carkill, Marie, MacPherson, Laura, Wainwright, Elanor N., Liddicoat, Brian, Blyth, Benjamin J., Albertella, Mark R., Rausch, Oliver, Dawson, Mark A.
Published in Cancer discovery (05.10.2023)
Published in Cancer discovery (05.10.2023)
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Journal Article
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.
Published in Nature communications (20.06.2019)
Published in Nature communications (20.06.2019)
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Journal Article
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Gilan, Omer, Talarmain, Laure, Bell, Charles C., Neville, Daniel, Knezevic, Kathy, Ferguson, Daniel T., Boudes, Marion, Chan, Yih-Chih, Davidovich, Chen, Lam, Enid Y. N., Dawson, Mark A.
Published in Nature structural & molecular biology (01.10.2023)
Published in Nature structural & molecular biology (01.10.2023)
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Journal Article
Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses
Chan, Kah Lok, Gomez, Juliana, Cardinez, Chelisa, Kumari, Nishi, Sparbier, Christina E., Lam, Enid Y.N., Yeung, Miriam M., Garciaz, Sylvain, Kuzich, James A., Ong, Doen Ming, Brown, Fiona C., Chan, Yih-Chih, Vassiliadis, Dane, Wainwright, Elanor N., Motazedian, Ali, Gillespie, Andrea, Fennell, Katie A., Lai, Junyun, House, Imran G., Macpherson, Laura, Ang, Ching-Seng, Dawson, Sarah-Jane, Beavis, Paul A., Wei, Andrew H., Burr, Marian L., Dawson, Mark A.
Published in Cancer cell (10.10.2022)
Published in Cancer cell (10.10.2022)
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Journal Article
SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
Tan, Vicky W.T., Salmi, Talhah M., Karamalakis, Anthony P., Gillespie, Andrea, Ong, Athena Jessica S., Balic, Jesse J., Chan, Yih-Chih, Bladen, Cerys E., Brown, Kristin K., Dawson, Mark A., Cox, Andrew G.
Published in Developmental cell (08.04.2024)
Published in Developmental cell (08.04.2024)
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Journal Article
Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
Kulkarni, Aishwarya, Mohan, Varshini, Tang, Tracy T, Post, Leonard, Chan, Yih-Chih, Manning, Murray, Thio, Niko, Parker, Benjamin L, Dawson, Mark A, Rosenbluh, Joseph, Vissers, Joseph HA, Harvey, Kieran F
Published in EMBO reports (10.09.2024)
Published in EMBO reports (10.09.2024)
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Journal Article
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Williams, Tobias D., Michalak, Ewa M., Carey, Kirstyn.T., Lam, Enid Y.N., Anderson, Ashley, Griesbach, Esther, Chan, Yih-Chih, Papasaikas, Panagiotis, Tan, Vicky W.T., Ngo, Linh, MacPherson, Laura, Gilan, Omer, Rucinski, Amber, Rutkowska-Klute, Anna, Zinn, Nico, Grandi, Paola, Bantscheff, Marcus, Prinjha, Rab K., Dawson, Sarah-Jane, Chao, Jeffrey A., Wickramasinghe, Vihandha O., Dawson, Mark A.
Published in Molecular cell (02.01.2025)
Published in Molecular cell (02.01.2025)
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Journal Article