Vyzkoušejte nový nástroj s podporou AI
Summon Research Assistant
BETA
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
Rapsomaniki, Eleni, Timmis, Adam, George, Julie, Pujades-Rodriguez, Mar, Shah, Anoop D, Denaxas, Spiros, White, Ian R, Caulfield, Mark J, Deanfield, John E, Smeeth, Liam, Williams, Bryan, Hingorani, Aroon, Hemingway, Harry
Published in The Lancet (British edition) (31.05.2014)
Published in The Lancet (British edition) (31.05.2014)
Get full text
Journal Article
Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes
Wei, Wei, Schon, Katherine R., Elgar, Greg, Orioli, Andrea, Tanguy, Melanie, Giess, Adam, Tischkowitz, Marc, Caulfield, Mark J., Chinnery, Patrick F.
Published in Nature (London) (03.11.2022)
Published in Nature (London) (03.11.2022)
Get full text
Journal Article
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
Williams, Bryan, MacDonald, Thomas M, Morant, Steve, Webb, David J, Sever, Peter, McInnes, Gordon, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Salsbury, Jackie, Mackenzie, Isla, Padmanabhan, Sandosh, Brown, Morris J
Published in The Lancet (British edition) (21.11.2015)
Published in The Lancet (British edition) (21.11.2015)
Get full text
Journal Article
The 100 000 Genomes Project: bringing whole genome sequencing to the NHS
Turnbull, Clare, Scott, Richard H, Thomas, Ellen, Jones, Louise, Murugaesu, Nirupa, Pretty, Freya Boardman, Halai, Dina, Baple, Emma, Craig, Clare, Hamblin, Angela, Henderson, Shirley, Patch, Christine, O’Neill, Amanda, Devereaux, Andrew, Smith, Katherine, Martin, Antonio Rueda, Sosinsky, Alona, McDonagh, Ellen M, Sultana, Razvan, Mueller, Michael, Smedley, Damian, Toms, Adam, Dinh, Lisa, Fowler, Tom, Bale, Mark, Hubbard, Tim, Rendon, Augusto, Hill, Sue, Caulfield, Mark J
Published in BMJ (Online) (24.04.2018)
Published in BMJ (Online) (24.04.2018)
Get full text
Journal Article
Pharmacogenetics and adverse drug reports: Insights from a United Kingdom national pharmacovigilance database
Magavern, Emma F., Megase, Maia, Thompson, Jack, Marengo, Gabriel, Jacobsen, Julius, Smedley, Damian, Caulfield, Mark J.
Published in PLoS medicine (27.03.2025)
Published in PLoS medicine (27.03.2025)
Get full text
Journal Article
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
Mega, Jessica L, Stitziel, Nathan O, Smith, J Gustav, Chasman, Daniel I, Caulfield, Mark J, Devlin, James J, Nordio, Francesco, Hyde, Craig L, Cannon, Christopher P, Sacks, Frank M, Poulter, Neil R, Sever, Peter S, Ridker, Paul M, Braunwald, Eugene, Melander, Olle, Kathiresan, Sekar, Sabatine, Marc S
Published in The Lancet (British edition) (06.06.2015)
Published in The Lancet (British edition) (06.06.2015)
Get full text
Journal Article
Advances in Blood Pressure Genomics
Munroe, Patricia B., Barnes, Michael R., Caulfield, Mark J.
Published in Circulation research (10.05.2013)
Published in Circulation research (10.05.2013)
Get full text
Journal Article
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon
Hartmann, Sylvia, Yasmeen, Summaira, Jacobs, Benjamin M., Denaxas, Spiros, Pirmohamed, Munir, Gamazon, Eric R., Caulfield, Mark J., Hemingway, Harry, Pietzner, Maik, Langenberg, Claudia
Published in Nature communications (12.10.2023)
Published in Nature communications (12.10.2023)
Get full text
Journal Article
Endothelial C-type natriuretic peptide maintains vascular homeostasis
Moyes, Amie J., Khambata, Rayomand S., Villar, Inmaculada, Bubb, Kristen J., Baliga, Reshma S., Lumsden, Natalie G., Xiao, Fang, Gane, Paul J., Rebstock, Anne-Sophie, Worthington, Roberta J., Simone, Michela I., Mota, Filipa, Rivilla, Fernando, Vallejo, Susana, Peiró, Concepción, Sánchez Ferrer, Carlos F., Djordjevic, Snezana, Caulfield, Mark J., MacAllister, Raymond J., Selwood, David L., Ahluwalia, Amrita, Hobbs, Adrian J.
Published in The Journal of clinical investigation (01.09.2014)
Published in The Journal of clinical investigation (01.09.2014)
Get full text
Journal Article
Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations
Balachandar, Srimmitha, Graves, Tamara J., Shimonty, Anika, Kerr, Katie, Kilner, Jill, Xiao, Sihao, Slade, Richard, Sroya, Manveer, Alikian, Mary, Curetean, Emanuel, Thomas, Ellen, McConnell, Vivienne P. M., McKee, Shane, Boardman‐Pretty, Freya, Devereau, Andrew, Fowler, Tom A., Caulfield, Mark J., Alton, Eric W., Ferguson, Teena, Redhead, Julian, McKnight, Amy J., Thomas, Geraldine A., Aldred, Micheala A., Shovlin, Claire L.
Published in American journal of medical genetics. Part A (01.03.2022)
Published in American journal of medical genetics. Part A (01.03.2022)
Get full text
Journal Article
ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant
Pu, Xiangyuan, Xiao, Qingzhong, Kiechl, Stefan, Chan, Kenneth, Ng, Fu Liang, Gor, Shivani, Poston, Robin N., Fang, Changcun, Patel, Ashish, Senver, Ece C., Shaw-Hawkins, Sue, Willeit, Johann, Liu, Chuanju, Zhu, Jianhua, Tucker, Arthur T., Xu, Qingbo, Caulfield, Mark J., Ye, Shu
Published in American journal of human genetics (07.03.2013)
Published in American journal of human genetics (07.03.2013)
Get full text
Journal Article
Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction
Yang, Wei, Ng, Fu Liang, Chan, Kenneth, Pu, Xiangyuan, Poston, Robin N., Ren, Meixia, An, Weiwei, Zhang, Ruoxin, Wu, Jingchun, Yan, Shunying, Situ, Haiteng, He, Xinjie, Chen, Yequn, Tan, Xuerui, Xiao, Qingzhong, Tucker, Arthur T., Caulfield, Mark J., Ye, Shu
Published in PLoS genetics (01.07.2016)
Published in PLoS genetics (01.07.2016)
Get full text
Journal Article
Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia
Wallace, Chris, Newhouse, Stephen J., Braund, Peter, Zhang, Feng, Tobin, Martin, Falchi, Mario, Ahmadi, Kourosh, Dobson, Richard J., Marçano, Ana Carolina B., Hajat, Cother, Burton, Paul, Deloukas, Panagiotis, Brown, Morris, Connell, John M., Dominiczak, Anna, Lathrop, G. Mark, Webster, John, Farrall, Martin, Spector, Tim, Samani, Nilesh J., Caulfield, Mark J., Munroe, Patricia B.
Published in American journal of human genetics (01.01.2008)
Published in American journal of human genetics (01.01.2008)
Get full text
Journal Article
Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial
Brown, Morris J, Williams, Bryan, Morant, Steve V, Webb, David J, Caulfield, Mark J, Cruickshank, J Kennedy, Ford, Ian, McInnes, Gordon, Sever, Peter, Salsbury, Jackie, Mackenzie, Isla S, Padmanabhan, Sandosh, MacDonald, Thomas M
Published in The lancet. Diabetes & endocrinology (01.02.2016)
Published in The lancet. Diabetes & endocrinology (01.02.2016)
Get full text
Journal Article
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study
Magavern, Emma F., Deshmukh, Harshal, Asselin, Geraldine, Theusch, Elizabeth, Trompet, Stella, Li, Xiaohui, Noordam, Raymond, Chen, Y.-D. Ida, Seeman, Teresa E., Taylor, Kent D., Post, Wendy S., Tardif, Jean-Claude, Paul, Dirk S., Benjamin, Emelia J., Heard-Costa, Nancy L., Vasan, Ramachandran S., Rotter, Jerome I., Krauss, Ronald M., Jukema, J.Wouter, Ridker, Paul M., Munroe, Patricia B., Caulfield, Mark J., Chasman, Daniel I., Dubé, Marie-Pierre, Hitman, Graham A., Warren, Helen R.
Published in Pharmacological research (01.02.2025)
Published in Pharmacological research (01.02.2025)
Get full text
Journal Article
Extracellular volume quantification in isolated hypertension - changes at the detectable limits?
Treibel, Thomas A., Zemrak, Filip, Sado, Daniel M., Banypersad, Sanjay M., White, Steven K., Maestrini, Viviana, Barison, Andrea, Patel, Vimal, Herrey, Anna S., Davies, Ceri, Caulfield, Mark J., Petersen, Steffen E., Moon, James C.
Published in Journal of cardiovascular magnetic resonance (12.08.2015)
Published in Journal of cardiovascular magnetic resonance (12.08.2015)
Get full text
Journal Article
CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel
Magavern, Emma F., Jacobs, Benjamin, Warren, Helen, Finocchiaro, Gherardo, Finer, Sarah, van Heel, David A., Smedley, Damian, Caulfield, Mark J.
Published in JACC. Advances (Online) (01.09.2023)
Published in JACC. Advances (Online) (01.09.2023)
Get full text
Journal Article
Personalized Antihypertensive Treatment Optimization With Smartphone‐Enabled Remote Precision Dosing of Amlodipine During the COVID‐19 Pandemic (PERSONAL‐CovidBP Trial)
Collier, David J., Taylor, Mike, Godec, Thomas, Shiel, Julian, James, Rebecca, Chowdury, Yasmin, Ebano, Patrizia, Monk, Vivienne, Patel, Mital, Pheby, Jane, Pheby, Ruby, Foubister, Amanda, David, Clovel, Saxena, Manish, Richardson, Leanne, Siddle, James, Timlin, Gregor, Goldsmith, Paul, Deeming, Nicholas, Poulter, Neil R., Gabe, Rhian, McManus, Richard J., Caulfield, Mark J.
Published in Journal of the American Heart Association (20.02.2024)
Published in Journal of the American Heart Association (20.02.2024)
Get full text
Journal Article
Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients: A Randomized, Phase 2, Double-Blind, Placebo-Controlled Study
Kapil, Vikas, Khambata, Rayomand S., Robertson, Amy, Caulfield, Mark J., Ahluwalia, Amrita
Published in Hypertension (Dallas, Tex. 1979) (01.02.2015)
Published in Hypertension (Dallas, Tex. 1979) (01.02.2015)
Get full text
Journal Article