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No QTc prolongation with CDK 4/6 inhibitor FCN-437c: results of a concentration-QTc analysis from a dedicated study in adult healthy subjects
Zhao, Lin, Sun, Yi, Yang, Xiaoran, Tian, Ling, Li, Lize, Wang, Fangfang, Niu, Xiaoye, Diao, Lei, Li, Haiyan
Published in Frontiers in pharmacology (12.08.2024)
Published in Frontiers in pharmacology (12.08.2024)
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Journal Article
Abstract P1-14-02: Phase II study of adjuvant endocrine therapy with CDK 4/6 inhibitor, ribociclib, for localized ER+/HER2- breast cancer (LEADER, part 1)
Spring, Laura M, Scarpetti, Lauren, Niemierko, Andrzej, Isakoff, Steven J, Moy, Beverly, Wander, Seth A, Smith, Elisabeth, Abraham, Elizabeth, Shin, Jennifer, Patel, Jaymin M, Comander, Amy, Mulvey, Therese, Bardia, Aditya
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
Abstract OT2-17-01: Randomized, multicenter, international phase 3 ARTEST study to evaluate the efficacy and safety of enobosarm versus active control for the treatment of AR+ ER+ HER2- metastatic breast cancer in patients who progressed on a nonsteroidal aromatase inhibitor, fulvestrant and CDK 4/6 inhibitor
Brufsky, Adam, Linden, Hannah, Rugo, Hope, Vogel, Charles, O'Shaughnessy, Joyce A, Getzenberg, Robert H, Barnette, K. Gary, Rodriguez, Domingo, Steiner, Mitchell S, Mayer, Erica
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
EPCT-05. A PHASE I TRIAL OF THE CDK 4/6 INHIBITOR PALBOCICLIB IN PEDIATRIC PATIENTS WITH PROGRESSIVE OR REFRACTORY CNS TUMORS: A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY
Van Mater, David, Gururangan, Sridharan, Leary, Sarah, Becher, Oren, Phillips, Joanna, Huang, Jie, Campagne, Olivia, Poussaint, Tina, Goldman, Stewart, Baxter, Patricia, Dhall, Girish, Robinson, Giles, DeWire-Schottmiller, Mariko, Hwang, Eugene, Stewart, Clinton, Onar-Thomas, Arzu, Dunkel, Ira, Fouladi, Maryam
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
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Journal Article
Abstract OT1-05-01: A phase I/II, single arm, non-randomized study of ribociclib (LEE011), a CDK 4/6 inhibitor, in combination with bicalutamide, an androgen receptor (AR) inhibitor, in advanced AR+ triple-negative breast cancer
Santa-Maria, CA, Rampurwala, M, Wisinski, K, Toppmeyer, D, O'Regan, R
Published in Cancer research (Chicago, Ill.) (15.02.2018)
Published in Cancer research (Chicago, Ill.) (15.02.2018)
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Journal Article
Vascular inflammation and cardiovascular burden in metastatic breast cancer female patients receiving hormonal treatment and CDK 4/6 inhibitors or everolimus
Papageorgiou, C, Zagouri, F, Dimopoulos, M, Manios, E, Kafouris, P, Tousoulis, D, Anagnostopoulos, C, Toutouzas, K
Published in European heart journal (01.11.2020)
Published in European heart journal (01.11.2020)
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Journal Article
Abstract OT2-01-02: The SMILE Study: A phase II trial of onapristone in combination with fulvestrant for patients with ER-positive and HER2-negative metastatic breast cancer after progression on endocrine therapy and CDK 4/6 inhibitors
Kamaraju, Sailaja, Fowler, Amy, Chaudhary, Lubna N., Burkard, Mark, Giever, Thomas, Hegeman, Robert N, Pipp-Dahm, Michele, Cheng, Yee Chung, Lange, Carol, Jorns, Julie M., Stella, Amy, Siddiqui, Nauman, Zurbriggen, Luke, Rajguru, Saurabh, Tarima, Sergey, Sriram, Deepika, Retseck, Janet, Rui, Hallgeir, Sahmoud, Tarek, Wisinski, Kari B.
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
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Journal Article
Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER)
Spring, Laura M., Scarpetti, Lauren, Medford, Arielle J., Niemierko, Andrzej, Comander, Amy, Mulvey, Therese, Schnipper, Lowell, Isakoff, Steven J., Moy, Beverly, Wander, Seth A., Shin, Jennifer, Ephrem, Zanta, Laposta, Anneke R., Denault, Elyssa, Abraham, Elizabeth, Calistro, Gayle, Kalashnikova, Ekaterina, Rodriguez, Angel, Liu, Minetta C., Aleshin, Alexey, Peppercorn, Jeffrey, Ellisen, Leif W., Bardia, Aditya
Published in NPJ breast cancer (07.01.2025)
Published in NPJ breast cancer (07.01.2025)
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Journal Article
A mass balance study of [14C]SHR6390 (dalpiciclib), a selective and potent CDK4/6 inhibitor in humans
Zhang, Hua, Yan, Shu, Zhan, Yan, Ma, Sheng, Bian, Yicong, Li, Shaorong, Tian, Junjun, Li, Guangze, Zhong, Dafang, Diao, Xingxing, Miao, Liyan
Published in Frontiers in pharmacology (31.03.2023)
Published in Frontiers in pharmacology (31.03.2023)
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Journal Article
Abstract PO2-27-03: Clinical Results of Subjects Remaining in the Phase 3 ARTEST Study Enobosarm Therapy in AR+ER+HER2- Metastatic Breast Cancer with 3 or Greater Prior Lines of Therapy
Rinn, Kristine, Jackson, Elisa Krill, Barnette, Gary, Rodriguez, Domingo, Shalev, Itay, Steiner, Mitchell, O'Shaughnessy, Joyce, Rugo, Hope, Brufsky, Adam
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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Journal Article
Abstract P4-10-03: Immunogenicity of SARS-CoV-2 vaccination in subjects on active treatment for breast cancer
Bivona, Cory, Li, Kevin, Sharma, Priyanka, He, Jianghua, Martin, Grace, Godwin, Andrew K, Rooney, Anthony, Williamson, Stephen, Doolittle, Gary, Sun, Weijing, Kimler, Bruce F, O'Dea, Anne P, Nye, Lauren E, McGuirk, Joseph P, Pessetto, Ziyan, Haney, Lisa, Balmaceda, Nicole, Mitchell, Laura, Finke, Karissa, Nelson, Maggie, Mudaranthakam, Dinesh Pal, Streeter, Natalie, Lafaver, Stephanie, Heldstab, Jaimie, Khan, Qamar J
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
A mass balance study of 14CSHR6390 (dalpiciclib), a selective and potent CDK4/6 inhibitor in humans
Zhang, Hua, Yan, Shu, Zhan, Yan, Ma, Sheng, Bian, Yicong, Li, Shaorong, Tian, Junjun, Li, Guangze, Zhong, Dafang, Diao, Xingxing, Miao, Liyan
Published in Frontiers in pharmacology (01.01.2023)
Published in Frontiers in pharmacology (01.01.2023)
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Journal Article
Ribociblib in Sequential Combination with Doxorubicin in Anthracycline-Naive Advanced Soft Tissue Sarcomas: Results of a Dose-Finding Phase 1B Study
Davis, Lara E, Zhu, Limin, Latour, Emile, McMahon, Nathan, Nishikawa, Go, Choo, Florence, Nusser, Kevin D, Pittsenbarger, Janét, Burch, Reid, Park, Byung, Mills, Gordon B, Davis, Jessica L, Davare, Monika, Ryan, Christopher W
Published in Clinical cancer research (09.05.2025)
Published in Clinical cancer research (09.05.2025)
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Journal Article
Abstract PO4-27-06: Design of Active Phase 3 ENABLAR-2 Study Evaluating Enobosarm +/- Abemaciclib in Patients with AR+ER+HER2- 2nd-Line Metastatic Breast Cancer Following Tumor Progression on an Estrogen Blocking Agent Plus Palbociclib or Ribociclib
Rinn, Kristine, Linden, Hannah, Schwartzberg, Lee, Barnette, Gary, Rodriguez, Domingo, Shalev, Itay, Steiner, Mitchell, Brufsky, Adam, O'Shaughnessy, Joyce
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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Journal Article
Everolimus and exemestane for the treatment of metastatic hormone receptor-positive breast cancer patients previously treated with CDK4/6 inhibitor based therapies
Cook, Madeline, Al Rabadi, Luai, Mitri, Zahi Ibrahim
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
Abstract 4626: A kit targeting detection of ESR1 mutations from circulating exosomal RNA and cell-free DNA supports longitudinal studies into endocrine therapy resistance in a broadly accessible RT-qPCR format
Brown, Justin T., Thibert, Julie R., Chen, Liangjing, Church, Melissa, Dale, Holli, Myers, Jamie, Hallmark, Elliot, Yociss, Megan, Sanchez, J Aquiles, Franzen, Kurt, Skog, Johan, Latham, Gary, Haynes, Brian, Statt, Sarah
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract CT419: A phase 1 randomized, open-label, 2-sequence, 2-period crossover study of the effect of multiple doses of palbociclib (PD-0332991) on midazolam pharmacokinetics in healthy women of non-childbearing potential
Hoffman, Justin T., Plotka, Anna, O'Gorman, Melissa, Loi, Cho-Ming, Kirkovsky, Leonid, Gallo-Stampino, Corrado, Wang, Diane
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article