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HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality
Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A., Hunt, Peter W., Sinclair, Elizabeth, Shacklett, Barbara L., Ferre, April L., Hayes, Timothy L., Somsouk, Ma, Hsue, Priscilla Y., Van Natta, Mark L., Meinert, Curtis L., Lederman, Michael M., Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M., Martin, Jeffrey N., McCune, Joseph M., Moreno, Santiago, Deeks, Steven G.
Published in PLoS pathogens (01.05.2014)
Published in PLoS pathogens (01.05.2014)
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Journal Article
CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial
Shah, Nirali N., Highfill, Steven L., Shalabi, Haneen, Yates, Bonnie, Jin, Jianjian, Wolters, Pamela L., Ombrello, Amanda, Steinberg, Seth M., Martin, Staci, Delbrook, Cindy, Hoffman, Leah, Little, Lauren, Ponduri, Anusha, Qin, Haiying, Qureshi, Haris, Dulau-Florea, Alina, Salem, Dalia, Wang, Hao-Wei, Yuan, Constance, Stetler-Stevenson, Maryalice, Panch, Sandhya, Tran, Minh, Mackall, Crystal L., Stroncek, David F., Fry, Terry J.
Published in Journal of clinical oncology (10.06.2020)
Published in Journal of clinical oncology (10.06.2020)
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Journal Article
The CD4:CD8 ratio is associated with markers of age‐associated disease in virally suppressed HIV‐infected patients with immunological recovery
Serrano‐Villar, S, Moreno, S, Fuentes‐Ferrer, M, Sánchez‐Marcos, C, Ávila, M, Sainz, T, Villar, NGP, Fernández‐Cruz, A, Estrada, V
Published in HIV medicine (01.01.2014)
Published in HIV medicine (01.01.2014)
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Journal Article
Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin
Gockel, Lukas M., Nekipelov, Katrin, Ferro, Vito, Bendas, Gerd, Schlesinger, Martin
Published in Cancer Immunology, Immunotherapy (01.10.2022)
Published in Cancer Immunology, Immunotherapy (01.10.2022)
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Journal Article
Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio
Serrano-Villar, Sergio, Pérez-Elías, María Jesús, Dronda, Fernando, Casado, José Luis, Moreno, Ana, Royuela, Ana, Pérez-Molina, José Antonio, Sainz, Talia, Navas, Enrique, Hermida, José Manuel, Quereda, Carmen, Moreno, Santiago
Published in PloS one (30.01.2014)
Published in PloS one (30.01.2014)
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Journal Article
Immunological features beyond CD4/CD8 ratio values in older individuals
Garrido-Rodríguez, Vanesa, Herrero-Fernández, Inés, Castro, María José, Castillo, Ana, Rosado-Sánchez, Isaac, Galvá, María Isabel, Ramos, Raquel, Olivas-Martínez, Israel, Bulnes-Ramos, Ángel, Cañizares, Julio, Leal, Manuel, Pacheco, Yolanda María
Published in Aging (Albany, NY.) (31.05.2021)
Published in Aging (Albany, NY.) (31.05.2021)
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Journal Article
CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection
Frahm, Marc A, Picking, Ralph A, Kuruc, JoAnn D, McGee, Kara S, Gay, Cynthia L, Eron, Joseph J, Hicks, Charles B, Tomaras, Georgia D, Ferrari, Guido
Published in The Journal of immunology (1950) (01.05.2012)
Published in The Journal of immunology (1950) (01.05.2012)
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Journal Article
Common gamma chain cytokines promote regulatory T cell development and survival at the CD4+ CD8+ stage in the human thymus
Vanhanen, Reetta, Tuulasvaara, Anni, Mattila, Joonatan, Pätilä, Tommi, Arstila, T. Petteri
Published in Scandinavian journal of immunology (01.08.2018)
Published in Scandinavian journal of immunology (01.08.2018)
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Journal Article
CD4+:CD8+ T-cell Ratio Changes in People with HIV Receiving Antiretroviral Treatment
Vivancos-Gallego, Maria J, Okhai, Hajra, Perez-Elías, Maria J, Gomez-Ayerbe, Cristina, Moreno-Zamora, Ana, Casado, Jose L, Quereda, Carmen, Sanz, Javier Martinez, Sanchez-Conde, Matilde, Serrano-Villar, Sergio, Campo, Santos Del, Dronda, Fernando, Galan, Juan Carlos, Sabin, Caroline A, Moreno, Santiago
Published in Antiviral therapy (01.01.2020)
Published in Antiviral therapy (01.01.2020)
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Journal Article
The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression
Serrano-Villar, Sergio, Gutiérrez, Carolina, Vallejo, Alejandro, Hernández-Novoa, Beatriz, Díaz, Laura, Abad Fernández, María, Madrid, Nadia, Dronda, Fernando, Zamora, Javier, Muñoz-Fernández, María Ángeles, Moreno, Santiago
Published in The Journal of infection (01.01.2013)
Published in The Journal of infection (01.01.2013)
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Journal Article
Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects
Rosado-Sánchez, I., Herrero-Fernández, I., Genebat, M., Ruiz-Mateos, E., Leal, M., Pacheco, Yolanda M.
Published in Clinical infectious diseases (15.01.2017)
Published in Clinical infectious diseases (15.01.2017)
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Journal Article
A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV
Triplette, Matthew, Attia, Engi F., Akgün, Kathleen M., Soo Hoo, Guy W., Freiberg, Matthew S., Butt, Adeel A., Wongtrakool, Cherry, Goetz, Matthew Bidwell, Brown, Sheldon T., Graber, Christopher J., Huang, Laurence, Crothers, Kristina
Published in PloS one (25.01.2017)
Published in PloS one (25.01.2017)
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Journal Article
Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis
Dave, Namita, Chevour, Priyanka, Mahendradas, Padmamalini, Venkatesh, Anitha, Kawali, Ankush, Shetty, Rohit, Ghosh, Arkasubhra, Sethu, Swaminathan
Published in Ocular immunology and inflammation (03.10.2019)
Published in Ocular immunology and inflammation (03.10.2019)
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Journal Article
Expression of programmed cell death protein 1 and T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus
Caraballo Cortés, Kamila, Osuch, Sylwia, Perlejewski, Karol, Pawełczyk, Agnieszka, Kaźmierczak, Justyna, Janiak, Maciej, Jabłońska, Joanna, Nazzal, Khalil, Stelmaszczyk‐Emmel, Anna, Berak, Hanna, Bukowska‐Ośko, Iwona, Paciorek, Marcin, Laskus, Tomasz, Radkowski, Marek
Published in Journal of viral hepatitis (01.08.2019)
Published in Journal of viral hepatitis (01.08.2019)
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Journal Article
The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
Garrido-Rodríguez, Vanesa, Bulnes-Ramos, Ángel, Olivas-Martínez, Israel, Pozo-Balado, María del Mar, Álvarez-Ríos, Ana Isabel, Gutiérrez, Félix, Izquierdo, Rebeca, García, Federico, Tiraboschi, Juan Manuel, Vera-Méndez, Francisco, Peraire, Joaquim, Rull, Anna, Pacheco, Yolanda María
Published in Journal of microbiology, immunology and infection (01.12.2024)
Published in Journal of microbiology, immunology and infection (01.12.2024)
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Journal Article
Age‐dependent accumulation of monoclonal CD4+CD8+double positive T lymphocytes in the peripheral blood of the elderly
Ghia, Paolo, Prato, Giuseppina, Stella, Stefania, Scielzo, Cristina, Geuna, Massimo, Caligaris‐Cappio, Federico
Published in British journal of haematology (01.12.2007)
Published in British journal of haematology (01.12.2007)
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Journal Article
Effects of Coronavirus Disease 2019 (COVID-19) on Peripheral Blood Lymphocytes and Their Subsets in Children: Imbalanced CD4+/CD8+ T Cell Ratio and Disease Severity
Mahmoudi, Shima, Yaghmaei, Bahareh, Sharifzadeh Ekbatani, Meisam, Pourakbari, Babak, Navaeian, Amene, Parvaneh, Nima, Haghi Ashtiani, Mohammad Taghi, Mamishi, Setareh
Published in Frontiers in pediatrics (14.04.2021)
Published in Frontiers in pediatrics (14.04.2021)
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Journal Article
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects
Rosado-Sánchez, I., Herrero-Fernández, I., Álvarez-Ríos, A. I., Genebat, M., Abad-Carrillo, M. A., Ruiz-Mateos, E., Pulido, F., González-García, J., Montero, M., Bernal-Morell, E., Vidal, F., Leal, M., Pacheco, Y. M.
Published in Antimicrobial agents and chemotherapy (01.08.2017)
Published in Antimicrobial agents and chemotherapy (01.08.2017)
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Journal Article
Glucose Transporter 1 Expression Identifies a Population of Cycling CD4+CD8+Human Thymocytes with High CXCR4-Induced Chemotaxis
Swainson, Louise, Kinet, Sandrina, Manel, Nicolas, Battini, Jean-Luc, Sitbon, Marc, Taylor, Naomi, Herzenberg, Leonard A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2005)
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Journal Article