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Transcriptional remodeling shapes therapeutic vulnerability to necroptosis in acute lymphoblastic leukemia
Saorin, Anna, Dehler, Anna, Galvan, Bartimée, Steffen, Fabio, Ray, Marine, Lu, Dong, Yu, Xin, Kim, James, Drakul, Aneta, Kisele, Samanta, Wang, Jin, Bourquin, Jean-Pierre, Bornhauser, Beat C.
Published in Blood (14.08.2025)
Published in Blood (14.08.2025)
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Journal Article
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7
McComb, Scott, Chan, Pik Ki, Guinot, Anna, Hartmannsdottir, Holmfridur, Jenni, Silvia, Dobay, Maria Pamela, Bourquin, Jean-Pierre, Bornhauser, Beat C
Published in Science advances (01.07.2019)
Published in Science advances (01.07.2019)
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Journal Article
Pharmacological disruption of the Notch transcription factor complex
Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
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Journal Article
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia
Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H., Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H., Brown, Timothy J., Collins, Robert H., Uhrig, Sebastian, Balasubramanian, Gnana P., Bandapalli, Obul R., Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L., Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina U., Saha, Vaskar, Irving, Julie A., Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W., Horvath, Peter, Bornhauser, Beat C., Bourquin, Jean-Pierre
Published in Blood (16.03.2017)
Published in Blood (16.03.2017)
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Journal Article
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
Bonapace, Laura, Bornhauser, Beat C., Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K., Schäfer, Beat W., Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre
Published in The Journal of clinical investigation (01.04.2010)
Published in The Journal of clinical investigation (01.04.2010)
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Journal Article
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies
Al Sayed, Mohamad F., Ruckstuhl, Carla A., Hilmenyuk, Tamara, Claus, Christina, Bourquin, Jean-Pierre, Bornhauser, Beat C., Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F.
Published in Blood (20.07.2017)
Published in Blood (20.07.2017)
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Journal Article
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
Vanden Bempt, Marlies, Demeyer, Sofie, Broux, Michaël, De Bie, Jolien, Bornschein, Simon, Mentens, Nicole, Vandepoel, Roel, Geerdens, Ellen, Radaelli, Enrico, Bornhauser, Beat C., Kulozik, Andreas E., Meijerink, Jules P., Bourquin, Jean-Pierre, de Bock, Charles E., Cools, Jan
Published in Cancer cell (13.08.2018)
Published in Cancer cell (13.08.2018)
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Journal Article
MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance
van der Zwet, Jordy C. G., Buijs-Gladdines, Jessica G. C. A. M., Cordo’, Valentina, Debets, Donna O., Smits, Willem K., Chen, Zhongli, Dylus, Jelle, Zaman, Guido J. R., Altelaar, Maarten, Oshima, Koichi, Bornhauser, Beat, Bourquin, Jean-Pierre, Cools, Jan, Ferrando, Adolfo A., Vormoor, Josef, Pieters, Rob, Vormoor, Britta, Meijerink, Jules P. P.
Published in Leukemia (01.12.2021)
Published in Leukemia (01.12.2021)
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Journal Article
Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia
Laurent, Anouchka P., Siret, Aurélie, Ignacimouttou, Cathy, Panchal, Kunjal, Diop, M'Boyba, Jenni, Silvia, Tsai, Yi-Chien, Roos-Weil, Damien, Aid, Zakia, Prade, Nais, Lagarde, Stephanie, Plassard, Damien, Pierron, Gaelle, Daudigeos, Estelle, Lecluse, Yann, Droin, Nathalie, Bornhauser, Beat C., Cheung, Laurence C., Crispino, John D., Gaudry, Muriel, Bernard, Olivier A., Macintyre, Elizabeth, Barin Bonnigal, Carole, Kotecha, Rishi S., Geoerger, Birgit, Ballerini, Paola, Bourquin, Jean-Pierre, Delabesse, Eric, Mercher, Thomas, Malinge, Sebastien
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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Journal Article
Single-cell analysis of structural variations and complex rearrangements with tri-channel processing
Sanders, Ashley D., Meiers, Sascha, Ghareghani, Maryam, Porubsky, David, Jeong, Hyobin, van Vliet, M. Alexandra C. C., Rausch, Tobias, Richter-Pechańska, Paulina, Kunz, Joachim B., Jenni, Silvia, Bolognini, Davide, Longo, Gabriel M. C., Raeder, Benjamin, Kinanen, Venla, Zimmermann, Jürgen, Benes, Vladimir, Schrappe, Martin, Mardin, Balca R., Kulozik, Andreas E., Bornhauser, Beat, Bourquin, Jean-Pierre, Marschall, Tobias, Korbel, Jan O.
Published in Nature biotechnology (01.03.2020)
Published in Nature biotechnology (01.03.2020)
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Journal Article
Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia
Costea, Julia, Rauwolf, Kerstin K., Zafferani, Pietro, Rausch, Tobias, Mathioudaki, Anna, Zaugg, Judith, Schrappe, Martin, Eckert, Cornelia, Escherich, Gabriele, Bourquin, Jean P., Bornhauser, Beat, Kulozik, Andreas E., Korbel, Jan O.
Published in Nature communications (27.06.2025)
Published in Nature communications (27.06.2025)
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Journal Article
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Vervoort, Britt M. T., Butler, Miriam, Grünewald, Kari J.T., Schenau, Dorette S. van Ingen, Tee, Trisha M., Lucas, Luc, Huitema, Alwin D. R., Boer, Judith M., Bornhauser, Beat C., Bourquin, Jean-Pierre, Hoogerbrugge, Peter M., Van der Velden, Vincent H.J., Kuiper, Roland P., Van der Meer, Laurens T., Van Leeuwen, Frank N.
Published in Haematologica (Roma) (01.12.2024)
Published in Haematologica (Roma) (01.12.2024)
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Journal Article
The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
Huang, Yun, Mouttet, Brice, Warnatz, Hans-Jörg, Risch, Thomas, Rietmann, Fabian, Frommelt, Fabian, Ngo, Quy A., Dobay, Maria Pamela, Marovca, Blerim, Jenni, Silvia, Tsai, Yi-Chien, Matzk, Sören, Amstislavskiy, Vyacheslav, Schrappe, Martin, Stanulla, Martin, Gstaiger, Matthias, Bornhauser, Beat, Yaspo, Marie-Laure, Bourquin, Jean-Pierre
Published in Cancer cell (09.12.2019)
Published in Cancer cell (09.12.2019)
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Journal Article
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Troester, Selina, Eder, Thomas, Wukowits, Nadja, Piontek, Martin, Fernández-Pernas, Pablo, Schmoellerl, Johannes, Haladik, Ben, Manhart, Gabriele, Allram, Melanie, Maurer-Granofszky, Margarita, Scheidegger, Nastassja, Nebral, Karin, Superti-Furga, Giulio, Meisel, Roland, Bornhauser, Beat, Valent, Peter, Dworzak, Michael N., Zuber, Johannes, Boztug, Kaan, Grebien, Florian
Published in Nature communications (19.05.2025)
Published in Nature communications (19.05.2025)
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Journal Article
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response
Ibrahim, Nurul Khalida, Schreek, Sabine, Cinar, Buesra, Stasche, Anna Sophie, Lee, Su Hyun, Zeug, Andre, Dolgner, Tim, Niessen, Julia, Ponimaskin, Evgeni, Shcherbata, Halyna, Fehlhaber, Beate, Bourquin, Jean-Pierre, Bornhauser, Beat, Stanulla, Martin, Pich, Andreas, Gutierrez, Alejandro, Hinze, Laura
Published in Cell reports (Cambridge) (22.04.2025)
Published in Cell reports (Cambridge) (22.04.2025)
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Journal Article
B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow
Barz, Malwine J., Behrmann, Lena, Capron, Danaëlle, Zuchtriegel, Gabriele, Steffen, Fabio D., Kunz, Leo, Zhang, Yang, Vermeerbergen, Iria Jimenez, Marovca, Blerim, Kirschmann, Moritz, Zech, Antonia, Nombela-Arrieta, César, Ziegler, Urs, Schroeder, Timm, Bornhauser, Beat, Bourquin, Jean-Pierre
Published in Haematologica (Roma) (01.05.2023)
Published in Haematologica (Roma) (01.05.2023)
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Journal Article
Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia
Blumel, Lena, Bernardi, Flavia, Picard, Daniel, Diaz, Jacob Torrejon, Jepsen, Vera H., Hasselmann, Rebecca, Schliehe-Diecks, Julian, Bartl, Jasmin, Qin, Nan, Bornhauser, Beat, Bhatia, Sanil, Marovka, Blerim, Marsaud, Veronique, Dingli, Florent, Loew, Damarys, Stanulla, Martin, Bourqin, Jean-Pierre, Borkhardt, Arndt, Remke, Marc, Ayrault, Olivier, Fischer, Ute
Published in Haematologica (Roma) (01.07.2024)
Published in Haematologica (Roma) (01.07.2024)
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Journal Article
Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1
Fettelschoss, Victoria, Burda, Patricie, Sagné, Corinne, Coelho, David, De Laet, Corinne, Lutz, Seraina, Suormala, Terttu, Fowler, Brian, Pietrancosta, Nicolas, Gasnier, Bruno, Bornhauser, Beat, Froese, D.Sean, Baumgartner, Matthias R.
Published in The Journal of biological chemistry (14.07.2017)
Published in The Journal of biological chemistry (14.07.2017)
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Journal Article
Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia
Zaliova, Marketa, Potuckova, Eliska, Lukes, Julius, Winkowska, Lucie, Starkova, Julia, Janotova, Iveta, Sramkova, Lucie, Stary, Jan, Zuna, Jan, Stanulla, Martin, Zimmermann, Martin, Bornhauser, Beat, Bourquin, Jean-Pierre, Eckert, Cornelia, Cario, Gunnar, Trka, Jan
Published in Haematologica (Roma) (01.03.2021)
Published in Haematologica (Roma) (01.03.2021)
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Journal Article