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A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
Swanson, Chad J., Zhang, Yong, Dhadda, Shobha, Wang, Jinping, Kaplow, June, Lai, Robert Y. K., Lannfelt, Lars, Bradley, Heather, Rabe, Martin, Koyama, Akihiko, Reyderman, Larisa, Berry, Donald A., Berry, Scott, Gordon, Robert, Kramer, Lynn D., Cummings, Jeffrey L.
Published in Alzheimer's research & therapy (17.04.2021)
Published in Alzheimer's research & therapy (17.04.2021)
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Journal Article
Lecanemab in patients with early Alzheimer’s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study
McDade, Eric, Cummings, Jeffrey L., Dhadda, Shobha, Swanson, Chad J., Reyderman, Larisa, Kanekiyo, Michio, Koyama, Akihiko, Irizarry, Michael, Kramer, Lynn D., Bateman, Randall J.
Published in Alzheimer's research & therapy (21.12.2022)
Published in Alzheimer's research & therapy (21.12.2022)
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Journal Article
Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval
Tolar, Martin, Abushakra, Susan, Hey, John A., Porsteinsson, Anton, Sabbagh, Marwan
Published in Alzheimer's research & therapy (12.08.2020)
Published in Alzheimer's research & therapy (12.08.2020)
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Journal Article
Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment
Cicognola, Claudia, Janelidze, Shorena, Hertze, Joakim, Zetterberg, Henrik, Blennow, Kaj, Mattsson-Carlgren, Niklas, Hansson, Oskar
Published in Alzheimer's research & therapy (27.03.2021)
Published in Alzheimer's research & therapy (27.03.2021)
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Journal Article
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
Vogt, Nicholas M., Romano, Kymberleigh A., Darst, Burcu F., Engelman, Corinne D., Johnson, Sterling C., Carlsson, Cynthia M., Asthana, Sanjay, Blennow, Kaj, Zetterberg, Henrik, Bendlin, Barbara B., Rey, Federico E.
Published in Alzheimer's research & therapy (22.12.2018)
Published in Alzheimer's research & therapy (22.12.2018)
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Journal Article
A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease
Ostrowitzki, Susanne, Lasser, Robert A., Dorflinger, Ernest, Scheltens, Philip, Barkhof, Frederik, Nikolcheva, Tania, Ashford, Elizabeth, Retout, Sylvie, Hofmann, Carsten, Delmar, Paul, Klein, Gregory, Andjelkovic, Mirjana, Dubois, Bruno, Boada, Mercè, Blennow, Kaj, Santarelli, Luca, Fontoura, Paulo
Published in Alzheimer's research & therapy (08.12.2017)
Published in Alzheimer's research & therapy (08.12.2017)
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Journal Article
Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
Phillips, Matthew C. L., Deprez, Laura M., Mortimer, Grace M. N., Murtagh, Deborah K. J., McCoy, Stacey, Mylchreest, Ruth, Gilbertson, Linda J., Clark, Karen M., Simpson, Patricia V., McManus, Eileen J., Oh, Jee-Eun, Yadavaraj, Satish, King, Vanessa M., Pillai, Avinesh, Romero-Ferrando, Beatriz, Brinkhuis, Martijn, Copeland, Bronwyn M., Samad, Shah, Liao, Shenyang, Schepel, Jan A. C.
Published in Alzheimer's research & therapy (23.02.2021)
Published in Alzheimer's research & therapy (23.02.2021)
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Journal Article
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Zhang, Jing, Feng, Teng, Cantillon, Marc, Chen, Kewei, Cummings, Jeffrey L., Ding, Jian, Geng, Meiyu, Zhang, Zhenxin
Published in Alzheimer's research & therapy (17.03.2021)
Published in Alzheimer's research & therapy (17.03.2021)
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Journal Article
Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
Dammer, Eric B., Ping, Lingyan, Duong, Duc M., Modeste, Erica S., Seyfried, Nicholas T., Lah, James J., Levey, Allan I., Johnson, Erik C. B.
Published in Alzheimer's research & therapy (17.11.2022)
Published in Alzheimer's research & therapy (17.11.2022)
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Journal Article
The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease
Colom-Cadena, Martí, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T., Fillit, Howard, Harrison, John E., Schneider, Lon S., Scheltens, Phillip, de Haan, Willem, Grundman, Michael, van Dyck, Christopher H., Izzo, Nicholas J., Catalano, Susan M.
Published in Alzheimer's research & therapy (02.03.2020)
Published in Alzheimer's research & therapy (02.03.2020)
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Journal Article
On the path to 2025: understanding the Alzheimer’s disease continuum
Aisen, Paul S., Cummings, Jeffrey, Jack, Clifford R., Morris, John C., Sperling, Reisa, Frölich, Lutz, Jones, Roy W., Dowsett, Sherie A., Matthews, Brandy R., Raskin, Joel, Scheltens, Philip, Dubois, Bruno
Published in Alzheimer's research & therapy (09.08.2017)
Published in Alzheimer's research & therapy (09.08.2017)
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Journal Article
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
Baiardi, Simone, Quadalti, Corinne, Mammana, Angela, Dellavalle, Sofia, Zenesini, Corrado, Sambati, Luisa, Pantieri, Roberta, Polischi, Barbara, Romano, Luciano, Suffritti, Matteo, Bentivenga, Giuseppe Mario, Randi, Vanda, Stanzani-Maserati, Michelangelo, Capellari, Sabina, Parchi, Piero
Published in Alzheimer's research & therapy (12.10.2022)
Published in Alzheimer's research & therapy (12.10.2022)
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Journal Article
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice
Simon, Matthew, Wang, Marie Xun, Ismail, Ozama, Braun, Molly, Schindler, Abigail G., Reemmer, Jesica, Wang, Zhongya, Haveliwala, Mariya A., O’Boyle, Ryan P., Han, Warren Y., Roese, Natalie, Grafe, Marjorie, Woltjer, Randall, Boison, Detlev, Iliff, Jeffrey J.
Published in Alzheimer's research & therapy (26.04.2022)
Published in Alzheimer's research & therapy (26.04.2022)
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Journal Article
Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
Verberk, Inge M. W., Thijssen, Elisabeth, Koelewijn, Jannet, Mauroo, Kimberley, Vanbrabant, Jeroen, de Wilde, Arno, Zwan, Marissa D., Verfaillie, Sander C. J., Ossenkoppele, Rik, Barkhof, Frederik, van Berckel, Bart N. M., Scheltens, Philip, van der Flier, Wiesje M., Stoops, Erik, Vanderstichele, Hugo M., Teunissen, Charlotte E.
Published in Alzheimer's research & therapy (28.09.2020)
Published in Alzheimer's research & therapy (28.09.2020)
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Journal Article