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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
Rossman, Eric I., Wisialowski, Todd A., Vargas, Hugo M., Valentin, Jean-Pierre, Rolf, Michael G., Roche, Brian M., Riley, Steve, Pugsley, Michael K., Nichols, Jill, Li, Dingzhou, Leishman, Derek J., Kleiman, Robert B., Greiter-Wilke, Andrea, Gintant, Gary A., Engwall, Michael J., Delaunois, Annie, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.09.2023)
Published in Journal of pharmacological and toxicological methods (01.09.2023)
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Journal Article
Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects
Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Oikawa, Ichiro, Ikeda, Naoki, Matsuda, Kazuki, Takei, Yoshinori, Matsumoto, Akio, Kumagai, Yuji, Sugiyama, Atsushi
Published in Journal of pharmacological sciences (01.11.2022)
Published in Journal of pharmacological sciences (01.11.2022)
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Journal Article
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments
Chaves, Alysia A., Ferraro, Jude W., Yu, Jing, Moye, Matthew J., Yee, Ka Lai, Li, Fangbiao, Steve, Desiree L., Lengel, David J., Regan, Christopher P.
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Published in Journal of pharmacological and toxicological methods (01.07.2024)
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Journal Article
Appraisal of ICH E14/S7B Q As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Ichiro Oikawa, Naoki Ikeda, Kazuki Matsuda, Yoshinori Takei, Akio Matsumoto, Yuji Kumagai, Atsushi Sugiyama
Published in Journal of pharmacological sciences (01.11.2022)
Published in Journal of pharmacological sciences (01.11.2022)
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Journal Article
QT interval correction assessment in the anesthetized guinea pig
Morissette, Pierre, Regan, Hillary K., Fitzgerald, Kevin, Bernasconi, Sylvain, Gerenser, Pamela, Travis, Jeffrey, Fanelli, Patrick, Sannajust, Frederick, Regan, Christopher P.
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Journal Article
Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes
Bot, Corina T., Juhasz, Krisztina, Haeusermann, Fabian, Polonchuk, Liudmila, Traebert, Martin, Stoelzle-Feix, Sonja
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species
Tichenor, Steve, Regan, Christopher, Foley, C. Michael, Nichols, Jill, Henderson, Kim, Rajamani, Sridharan, Champeroux, Pascal, Li, Dingzhou, Roche, Brian, Rollins, Korynne
Published in Journal of pharmacological and toxicological methods (01.05.2025)
Published in Journal of pharmacological and toxicological methods (01.05.2025)
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Journal Article
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19
Dannebaum, Richard, Suwalski, Phillip, Asgharian, Hosseinali, Du Zhipei, Gracie, Lin, Hai, Weiner, January, Holtgrewe, Manuel, Thibeault, Charlotte, Müller, Melina, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Blüher, Anja, Siemann, Sandra, Telman, Dilduz, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Skurk, Carsten, Poller, Wolfgang, Sander, Leif E, Beule, Dieter, Kurth, Florian, Guettouche, Toumy, Landmesser, Ulf, Berka, Jan, Luong, Khai, Rubelt, Florian, Heidecker, Bettina
Published in EClinicalMedicine (01.06.2022)
Published in EClinicalMedicine (01.06.2022)
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Journal Article
Towards best practices: A cross-company survey of nonclinical C-QT analysis in drug development
Wisialowski, Todd A., Popp, Julia, Nichols, Jill V., Roche, Brian, Ether, Nick, Vargas, Hugo, Martel, Eric, Rajamani, Sridharan, Rossman, Eric, Foley, C. Michael, Riley, Steve
Published in Journal of pharmacological and toxicological methods (01.05.2025)
Published in Journal of pharmacological and toxicological methods (01.05.2025)
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Journal Article