Drug transporters : molecular characterization and role in drug disposition

"Unique in the field of pharmaceutical science, this revised 3rd edition takes into account that knowledge in transporters as drug targets for diseases has expanded. Since publication of the second edition, there have been significant advances in the field: in-depth understanding of membrane tr...

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Bibliographic Details
Other Authors You, Guofeng (Editor), Morris, Marilyn Emily (Editor)
Format Electronic eBook
LanguageEnglish
Published Hoboken, NJ : John Wiley & Sons, Inc., 2022.
EditionThird edition.
SeriesWiley series in drug discovery and development.
Subjects
Carrier proteins.
Drug carriers (Pharmacy)
Pharmacokinetics.
elektronické knihy
electronic books
Online AccessFull text
ISBN9781119739883
1119739888
9781119739876
111973987X
9781119739869
1119739861
9781119737551
1119737559
Physical Description1 online resource (xxii, 552 pages) : illustrations (chiefly color).

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Table of Contents:
  • Overview of drug transporter families / Guofeng You and Marilyn E. Morris
  • Organic Cation and Zwitterion transporters / Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and Kathleen M. Giacomini
  • Multidrug and toxin extrusion proteins / Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy
  • Organic anion transporters (OATs) / Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam
  • Organic anion transporting polypeptides OATP / Rommel G. Tirona and Richard B. Kim
  • Mammalian oligopeptide transporters / Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp
  • Monocarboxylic acid transporters / Marilyn E. Morris and Nisha V. Kwatra
  • The nucleoside transporters CNTs and ENTs / Raj Govindarajan, Antonio López Quiñones, and Joanne Wang
  • Bile acid transporters / Ebehiremen N. Ayewoh and Peter W. Swaan
  • The P-glycoprotein multidrug transporter / Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar
  • Multidrug resistance proteins of the ABCC subfamily / Anne T. Nies and Franziska Klein
  • ABCG2, the breast cancer resistance protein (BCRP) / Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates
  • Drug transport in the liver / Noora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer
  • Drug transport in the brain / Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan
  • Drug transport in the kidney / Douglas H. Sweet
  • Drug transporters in the human intestine / Stefan Oswald
  • Drug transport in the placenta / Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat
  • Polymorphisms of drug transporters and clinical relevance / Tore B. Stage and Deanna L. Kroetz
  • Ontogeny of drug transporters / Melanie A. Felmlee and Qing Zhang
  • Experimental approaches for studying drug transporters / Yusuke Masuo, Azusa Futatsugi, and Yukio Kato
  • Transporters mediated drug disposition : physiochemistry and in silico approaches / Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai
  • In vitro-in vivo scale-up of drug transport activities / Kazuya Maeda and Yuichi Sugiyama
  • Application of physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling comprising transporters : delineating the role of various factors in drug disposition and toxicity / Matthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff
  • Transporters as therapeutic targets in human diseases / Robert S. Jones and Eugene C. Chen
  • Diet/nutrient interactions with drug transporters / Marilyn E. Morris and Tianjing Ren.

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