Production and Quality Control of Fluorine-18 Labelled Radiopharmaceuticals

Since their clinical use initiation in the 1970's, Fluorine-18 (F-18) radiopharmaceuticals continue to play an important role in nuclear medicine. It is therefore essential to make available broad information on practical production routes and optimal quality control for F-18 tracers, to achiev...

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Bibliographic Details
Main Author IAEA
Format Electronic eBook
LanguageEnglish
Published Vienna : IAEA, 2021.
SeriesIAEA-TECDOC.
Subjects
Online AccessFull text
ISBN9789201226211
9201226217
Physical Description1 online resource (168 p.).

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520 |a Since their clinical use initiation in the 1970's, Fluorine-18 (F-18) radiopharmaceuticals continue to play an important role in nuclear medicine. It is therefore essential to make available broad information on practical production routes and optimal quality control for F-18 tracers, to achieve the best possible products in high quantity and quality for clinical applications while fulfilling all regulatory requirements. This publication describes the chemical and biological properties of F-18 radiopharmaceuticals. This includes aspects relating to F-18 target production and radiofluorination methods, with focus on the applied techniques. The publication presents a disease oriented approach, describing F-18 radiopharmaceuticals, ranging from the physiological/biological aspects to dedicated radiopharmaceutical development approaches and provides readers with clear guidelines and methods for the production of F-18 radiopharmaceuticals. 
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