Organometallic chemistry in industry : a practical approach

• Other Authors: Colacot, Thomas, (Editor), Seechurn, Carin C. C. Johansson, (Editor), Grubbs, Robert H., (writer of foreword.)
• Format: eBook
• Language: English
• Published: Weinheim : Wiley-VCH, [2020]
• Subjects: Organometallic chemistry.; elektronické knihy; electronic books
• ISBN: 9783527819201; 3527819207; 9783527819195; 3527819193; 9783527819171; 3527819177; 9783527345175; 3527345175
• Physical Description: 1 online resource (338 pages) : illustrations
• Item Description: 3.5.1 Manufacture of Verubecestat (MK-8931)
• Access: Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty

"Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R & D researchers as well as Ph. D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates."--