The handbook of continuous crystallization

Continuous crystallization is an area of intense research, with particular respect to the pharmaceutical industry and fine chemicals. Improvements in continuous crystallization technologies offer chemical industries significant financial gains, through reduced expenditure and operational costs, and...

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Bibliographic Details
Other Authors Yazdanpanah, Nima (Editor), Nagy, Zoltan K. (Editor)
Format Electronic eBook
LanguageEnglish
Published London : The Royal Society of Chemistry, 2020.
Subjects
Crystallization.
elektronické knihy
electronic books
Online AccessFull text
ISBN9781788013581
1788013581
9781839161315
1839161310
9781788012140
1788012143
Physical Description1 online resource (xix, 609 pages)

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Table of Contents:
  • Intro
  • Half title
  • Title
  • Copyright
  • Preface
  • Contents
  • Chapter 1 Nucleation and Crystal Growth in Continuous Crystallization
  • 1.1 Introduction
  • 1.2 Crystal Nucleation
  • 1.2.1 Primary Nucleation
  • 1.2.2 Secondary Nucleation
  • 1.3 Continuous Crystallization
  • 1.3.1 Crystalline Product Quality Attributes
  • 1.3.2 Continuous Heterogeneous Crystallization on Excipient Surfaces
  • 1.3.3 Agitated Vessel Type Crystallization Process
  • 1.3.4 Plug Flow Type Crystallization Process
  • 1.4 Continuous Seeding and Nucleators
  • 1.4.1 Continuous Seeding
  • 1.4.2 Decoupling Nucleation and Growth in Continuous Crystallization
  • 1.4.3 Continuous Nucleators
  • 1.4.4 Supersaturation Control by Rapid or Non-rapid Mixing
  • 1.4.5 Ultrasound Induced Nucleation
  • 1.4.6 Fully Continuous Crystallization in an MSMPR Cascade
  • 1.4.7 Continuous MSMPR Cascade with Batch Crystallization Start Up
  • 1.4.8 High Shear Wet Mill in MSMPR Configuration
  • 1.4.9 Secondary Nucleators
  • References
  • Chapter 2 Fundamentals of Population Balance Based Crystallization Process Modeling
  • 2.1 Introduction
  • 2.2 Modeling of Fundamental Crystallization Mechanisms
  • 2.2.1 The Supersaturation
  • 2.2.2 Nucleation
  • 2.2.3 Growth and Dissolution
  • 2.2.4 Modeling Crystal Agglomeration
  • 2.2.5 Modeling Crystal Breakage
  • 2.3 Modeling the MSMPR Crystallizer
  • 2.3.1 MSMPR Crystallizer Configurations
  • 2.4 Modeling the Tubular Crystallizer
  • 2.4.1 Case Study: PFC With Multiple Feeding Points
  • 2.5 Numerical Solution Methods for the Population Balance Equations
  • 2.5.1 Moment Based Methods
  • 2.5.2 Method of Characteristics
  • 2.5.3 Finite Volume Methods
  • 2.6 Advanced Crystallization Modeling
  • Case Studies
  • 2.6.1 Modeling Solvent Mediated Polymorphic Transformation
  • 2.6.2 Modeling Preferential Crystallization of Enantiomers
  • 2.7 The Growth Rate Dispersion (GRD)
  • References
  • Chapter 3 Continuous Crystallisation With Oscillatory Baffled Crystalliser Technology
  • 3.1 Introduction
  • 3.2 Plug Flow
  • 3.2.1 The Definition
  • 3.2.2 How to Measure Plug Flow
  • 3.2.3 How Could Near Plug Flow Be Achieved in the Real World?
  • 3.3 Continuous Oscillatory Baffled Crystalliser
  • 3.3.1 Principles
  • 3.3.2 Mixing Evaluation in Single Phase
  • 3.3.3 Mixing Evaluation in Two Phases
  • 3.3.4 Moving Fluid vs. Moving Baffles
  • 3.3.5 Scaling Up and Down
  • 3.3.6 Power Dissipation
  • 3.4 Design and Operation of Continuous Oscillatory Baffled Crystalliser
  • 3.4.1 Linking the Design and Operation With Science
  • 3.5 What Has Been Done?
  • 3.5.1 Cooling Crystallisation
  • 3.5.2 Antisolvent Crystallisation and Seed Generator
  • 3.5.3 Nucleation by Scraping
  • 3.5.4 Encrustation
  • 3.5.5 PAT Implementation
  • 3.6 What Are the Opportunities and Challenges?
  • 3.6.1 Reactive Crystallisation
  • 3.6.2 Co-crystallisation
  • 3.6.3 Crystallisation of Energetic Materials

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