Biomedical composites

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Bibliographic Details
Other Authors Ambrosio, Luigi, 1955- (Editor)
Format Electronic eBook
LanguageEnglish
Published Oxford : Woodhead Publishing, 2017.
EditionSecond edition.
SeriesWoodhead Publishing series in biomaterials.
Subjects
Biomedical materials.
Composite materials.
Biomedical engineering.
Tissue engineering.
elektronické knihy
electronic books
Online AccessFull text
ISBN9780081007594
0081007590
9780081007525
0081007523
Physical Description1 online resource.

Cover

Table of Contents:
  • Front Cover
  • Biomedical Composites
  • Copyright
  • Contents
  • List of contributors
  • Introduction
  • Chapter 1: Natural composites: The structure-function relationships of bone, cartilage, tendon/ligament, and the intervert ...
  • 1.1 Introduction
  • 1.2 Bone
  • 1.2.1 Bone structure and composition
  • 1.2.2 Bone cells and bone biology
  • 1.2.3 Bone mechanics at multiple scales
  • 1.3 Cartilage
  • 1.3.1 Cartilage composition and biology
  • 1.3.2 Cartilage mechanical behaviour
  • 1.4 Tendon/ligament
  • 1.4.1 Tendon/ligament composition and biology
  • 1.4.2 Tendon/ligament mechanical behaviour
  • 1.5 Intervertebral disc
  • 1.5.1 Intervertebral disc composition and biology
  • 1.5.2 Intervertebral disc mechanical behaviour
  • 1.6 Conclusions: Lessons learned and implications for repair, replacements, and regeneration
  • References
  • Sources of additional information
  • Chapter 2: Design and fabrication methods for biocomposites
  • 2.1 Introduction
  • 2.2 Production techniques for biocomposite parts
  • 2.3 Conventional composite processing techniques
  • 2.3.1 Extrusion and injection for thermoplastic materials
  • 2.3.2 Filament winding
  • 2.3.3 Compression
  • 2.3.4 Infusion
  • 2.3.5 Autoclaving
  • 2.4 Solution-based techniques
  • 2.4.1 Solvent casting
  • 2.4.2 Phase separation
  • 2.4.3 Electrospinning
  • 2.5 AM technologies
  • 2.6 Influence of the processing parameters on the material characteristics of biocomposites
  • 2.7 Designing with biocomposites for tissue engineering applications
  • 2.8 Conclusions
  • References
  • Chapter 3: Hard tissue applications of biocomposites
  • 3.1 Introduction
  • 3.2 Head and neck applications
  • 3.2.1 Maxillofacial applications
  • 3.2.2 Aural applications
  • 3.2.3 Dental applications
  • 3.3 Axial skeleton applications
  • 3.3.1 Internal applications
  • 3.3.2 External applications.
  • 3.4 Advantages in the use of composites for hard tissue applications
  • 3.5 Disadvantages in the use of composites for hard tissue applications
  • 3.6 Future trends
  • References
  • Chapter 4: Soft tissue application of biocomposites
  • 4.1 The multiphase composition of natural tissues: Inspiration from living soft tissue composites
  • 4.1.1 Soft tissues as structural composites
  • 4.1.2 Soft tissues as composite hydrogels
  • 4.1.3 Soft tissues as multifunctional composites
  • 4.1.4 Biophysical cues of soft tissue composites
  • 4.2 Engineered biocomposites for soft tissue application
  • 4.2.1 Biomimetic and bioinspired structural biocomposites
  • 4.2.2 Biocomposites to control molecular diffusion
  • 4.2.2.1 Biocomposites to guide tissue regeneration
  • 4.2.2.2 Biocomposites for cancer treatment
  • 4.2.3 Multifunctional biocomposites
  • 4.2.3.1 Electroactive soft biocomposites
  • 4.2.3.2 Magnetic soft biocomposites
  • 4.2.3.3 Micro and nanopatterned soft biocomposites
  • 4.2.4 Composites to monitor biological signals
  • 4.3 Conclusions: Engineered composites for soft tissues
  • References
  • Chapter 5: Composite materials for bone repair
  • 5.1 Introduction
  • 5.2 Component selection and general design considerations
  • 5.3 Fabrication of particulate composites
  • 5.4 Fabrication of nanocomposites
  • 5.5 Composite scaffolds
  • 5.6 Mechanisms for enhancing mechanical properties
  • 5.7 Conclusions and future trends
  • References
  • Further Reading
  • Chapter 6: Composite coatings for implants and tissue engineering scaffolds
  • 6.1 Introduction
  • 6.2 Types of composite coatings
  • 6.2.1 Anti-wear coatings
  • 6.2.2 Biocompatible coatings
  • 6.2.3 AntiBacterial coatings
  • 6.3 Synthesis of composite coatings
  • 6.3.1 Chemical deposition
  • 6.3.2 Electrophoretic deposition
  • 6.3.3 Electrochemical deposition (anodising, electroplating).
  • 6.3.4 Biomimetic deposition
  • 6.3.5 Other deposition methods
  • 6.4 Smart composite coatings
  • 6.5 Summary
  • Acknowledgements
  • References
  • Chapter 7: Composite materials for spinal implants
  • 7.1 Introduction
  • 7.2 Structure and function of the spine
  • 7.3 Materials and design of spinal implants: the state of the art
  • 7.3.1 Interbody spacers
  • 7.3.2 IVD prostheses
  • 7.4 Composite materials: basic concepts
  • 7.5 Polymer-based composite materials for spinal implants
  • 7.5.1 Composite interbody fusion devices
  • 7.5.2 Composite IVD prostheses
  • 7.6 Conclusions and future trends
  • References
  • Further Reading
  • Chapter 8: Collagen/chitosan composite scaffolds for bone and cartilage tissue engineering
  • 8.1 Introduction
  • 8.1.1 Bone
  • 8.1.1.1 Bone function and structure
  • 8.1.1.2 Bone lesions
  • 8.1.1.3 Current bone treatment options
  • 8.1.2 Cartilage
  • 8.1.2.1 Cartilage function and structure
  • 8.1.2.2 Cartilage lesions
  • 8.1.2.3 Current cartilage treatment options
  • 8.1.3 Tissue engineering
  • 8.1.3.1 Biomaterials for tissue engineering
  • Collagen as a biomaterial for tissue engineering
  • Chitosan
  • Chitosan as a GAG analog
  • Biocompatibility and degradation
  • 8.1.3.2 Bone tissue engineering
  • Collagen-based scaffolds for bone tissue engineering
  • Commercially available collagen-based scaffolds for bone tissue engineering
  • Chitosan scaffolds for bone repair
  • Collagen/chitosan scaffolds as in vitro osteoid models
  • 8.1.3.3 Cartilage tissue engineering
  • Collagen-based scaffolds for cartilage tissue engineering
  • Commercially available collagen-based scaffolds for cartilage tissue engineering
  • Chitosan scaffolds for cartilage repair
  • Collagen/chitosan composite scaffolds for cartilage tissue engineering
  • 8.2 Conclusions and future perspectives
  • References
  • Further Reading.
  • Chapter 9: Acrylic bone cements for joint replacement
  • 9.1 Introduction
  • 9.2 A brief history of bone cement
  • 9.3 Biomechanical properties of bone cement
  • 9.3.1 Composition
  • 9.3.2 Storage
  • 9.3.3 Viscosity
  • 9.3.4 Deformation
  • 9.3.5 Thermal properties
  • 9.3.6 Interdigitation
  • 9.3.7 Cement curing
  • 9.3.8 Cement application and the impact of the implant
  • 9.4 Contemporary use: the role of bone cement in arthroplasty
  • 9.4.1 Total Hip arthroplasty
  • 9.4.2 Total knee arthroplasty
  • 9.4.3 Total shoulder and total ankle arthroplasty
  • 9.4.4 The role of bone cement in infection
  • 9.4.5 Factors affecting antibiotic elution
  • 9.4.6 Methods of mixing antibiotic-impregnated cement
  • 9.5 Complications associated with bone cement
  • 9.5.1 Aseptic loosening
  • 9.5.2 Bone cement implantation syndrome
  • 9.6 Conclusion
  • References
  • Chapter 10: Composite materials for ligaments and tendons replacement
  • 10.1 Introduction
  • 10.2 Ligaments and tendons: Tissue biology and anatomy
  • 10.3 State of the art on proposed devices for ligaments and tendons replacement
  • 10.4 Fibre-reinforced composite materials: Fundamentals and technology
  • 10.4.1 Principles of soft composite design
  • 10.5 Composite materials for tissue replacement and tissue-engineered scaffolds
  • 10.6 Conclusion and prospective about composite materials for ligaments and tendons replacement and regeneration
  • References
  • Further Reading
  • Chapter 11: Composite materials for hip joint prostheses
  • 11.1 Introduction
  • 11.2 Properties of the hip joint
  • 11.3 Materials for hip arthroplasty
  • 11.3.1 Composite bone cements
  • 11.3.2 Materials for acetabular cups
  • 11.3.2.1 Hydroxyapatite-reinforced polymers for acetabular cups
  • 11.3.3 Materials for hip stem
  • 11.4 Polymer-based composite hip
  • 11.4.1 Stem technologies
  • 11.4.2 Polymer-based composite femoral stem.
  • 11.4.3 Modelling
  • 11.4.4 In vitro testing
  • 11.5 Future trends
  • References
  • Further Reading
  • Chapter 12: 3D printing of biocomposites for osteochondral tissue engineering
  • 12.1 Introduction
  • 12.2 Osteochondral tissue
  • 12.3 Scaffold requirements
  • 12.3.1 Biocompatibility
  • 12.3.2 Biomimicry
  • 12.3.3 Biodegradation
  • 12.3.4 Scaffold architecture and mechanical properties
  • 12.3.5 Printability
  • 12.3.6 Clinical translation
  • 12.4 Materials
  • 12.4.1 Natural polymers
  • 12.4.2 Synthetic polymers
  • 12.4.3 Inorganic materials
  • 12.4.4 Biological materials
  • 12.5 3D printing techniques
  • 12.5.1 Inkjet printing
  • 12.5.2 Extrusion-based printing
  • 12.5.3 Powder-bed fusion
  • 12.5.4 Vat-photopolymerisation process
  • 12.5.5 Melt electrospinning writing
  • 12.6 Future challenges
  • 12.7 Conclusion
  • Acknowledgements
  • References
  • Chapter 13: The challenge of biocompatibility evaluation of biocomposites
  • 13.1 Introduction
  • 13.2 Biocomposites
  • 13.3 Do we need biocompatibility evaluation?
  • 13.3.1 Data collection from scientific literature
  • 13.3.2 Data collection from materials suppliers/industries
  • 13.3.3 Data collection from analytical analyses
  • 13.3.4 Data collection from clinical analyses
  • 13.4 Selection of biocompatibility analyses/biological test methods
  • 13.4.0.1 Cytotoxicity or cell viability
  • 13.4.1 Sensitisation
  • 13.4.2 Irritation
  • 13.4.3 Acute systemic toxicity and subchronic tests
  • 13.4.4 Genotoxicity
  • 13.4.5 Implantation and hemocompatibility
  • 13.4.6 Biodegradation
  • 13.5 Biocomposites-based biocompatibility studies
  • 13.6 Biocompatibility and the implantation of a biocomposite in a biological environment
  • 13.7 Concluding remarks and future perspectives
  • Acknowledgements
  • References
  • Further Reading
  • Chapter 14: Cellular response to biocomposites
  • 14.1 Introduction.

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