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Nutraceuticals: Efficacy, Safety and Toxicity brings together all current knowledge regarding nutraceuticals and their potential toxic effects as written by the scientists at the forefront of their study. Users will find an introduction to nutraceuticals, herbal medicines, ayurvedic medicines, prebiotics, probiotics, and adaptogens, along with their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines.
Front Cover; Nutraceuticals; Copyright Page; Dedication; Contents; List of Contributors; Introduction; Introduction; References; I. Applications of Nutraceuticals in Common Diseases and Disorders; 1 Nutraceuticals in CNS Diseases: Potential Mechanisms of Neuroprotection; Introduction; Polyphenols; Counteracting Oxidative Stress as a Mechanism of Neuroprotection; Direct Antioxidant Action of Quercetin; Potential Role of Hormesis in Neuroprotection; Modulation of the Nrf2-ARE Pathway as a Mechanism of Quercetin Neuroprotection.
Modulation of Paraoxonase 2 (PON2) as a Potential Novel Mechanism of Quercetin NeuroprotectionParaoxonase 2; Paraoxonase 2 in the Central Nervous System; Gender Differences in Paraoxonase 2 Expression; Modulation of Paraoxonase 2; Modulation of Paraoxonase 2 by Quercetin; The Issue of Metabolites; Concluding Remarks and Future Directions; Acknowledgments; References; 2 Prevention of Neurodegenerative Disorders by Nutraceuticals; Introduction; Nutraceuticals for the Prevention and Amelioration of AD; Nutraceuticals for the Prevention and Amelioration of PD.
Nutraceuticals for the Prevention and Amelioration of ASDConcluding Remarks and Future Directions; References; 3 Cognitive Effects of Nutraceuticals; Introduction; Biological Basis of Cognition; Overview of Cognition; Cellular Basis of Information Storage; Synaptic Plasticity as a Physical Basis for Memory; Biological Basis of Dementia; Nutraceuticals with Potential Cognitive Enhancing Functions; Ginkgo biloba; Positive Effects; Potential Mechanisms; Negative or Null Effects; Bacopa monnieri; Positive Effects; Potential Mechanisms; Negative or Null Effects; Ginseng; Positive Effects.
Potential MechanismNegative or Null Effects; Phosphatidylserine; Positive Effects; Potential Mechanisms; Negative or Null Effects; Caffeine; Positive Effects; Potential Mechanisms; Negative or Null Effects; Centella asiatica, Ephedra sinica, and Crocus sativus; Potential Concerns of Cognitive Enhancement; Concluding Remarks and Future Directions; References; 4 Nutraceuticals in Cardiovascular Diseases; Introduction; Cardiac Dysfunction; Features of Cardiac Disease; Hypertension; Coronary Artery Disease (CAD)-Atherosclerosis; Ischemia; Hypertrophy; Oxidative Stress; Vascular Injury.
Biomarkers of Heart DiseaseTherapeutic Response to Heart Disease; Phytotherapeutic Strategies; Nutraceuticals; Cruciferous Vegetables; Bulbous Plants; Tea; CoQ10; Turmeric; Grape Skin; Fish Oil/Olive Oil; Vegetables; Carnitine; Soy; Concluding Remarks and Future Directions; References; 5 Antiatherosclerotic Efficacy of Nutraceuticals; Introduction; Pathogenesis of Atherosclerosis and Possible Points of Therapeutic Intervention; Role of LDL; Atherosclerotic Plaque Formation; Existing and Emerging Antiatherosclerotic Therapies; Nutraceuticals with Antiatherosclerotic Activity.
Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty
Includes bibliographical references and index.
Nutraceuticals : efficacy, safety and toxicity
Amsterdam, [Netherlands] : Academic Press, ©2016