Concepts and models for drug permeability studies : cell and tissue based In vitro culture models

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Bibliographic Details
Other Authors: Sarmento, Bruno, (Editor)
Format: eBook
Language: English
Published: Amsterdam : Elsevier Ltd., 2016.
Series: Woodhead Publishing series in biomedicine ; no. 79.
Subjects:
Drugs > Testing.
Drugs > Physiological transport > Research > Methodology.
Epithelial cells.
Cell culture.
Permeability.
Pharmacokinetics.
Biological models.
elektronické knihy
electronic books
ISBN: 9780081001141
0081001142
9780081000946
0081000944
Physical Description: 1 online resource

Cover

Table of contents

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245 0 0 |a Concepts and models for drug permeability studies :  |b cell and tissue based In vitro culture models /  |c edited by Bruno Sarmento. 
264 1 |a Amsterdam :  |b Elsevier Ltd.,  |c 2016. 
264 4 |c ©2016 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Woodhead Publishing series in biomedicine ;  |v number 79 
504 |a Includes bibliographical references and index. 
505 0 |a Front Cover; Related titles; Concepts and Models for Drug Permeability Studies; Copyright; Contents; List of contributors; List of figures; List of tables; 1 -- Introduction; 1.1 Introduction; References; 2 -- Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages o ... ; 2.1 Introduction; 2.2 General considerations; 2.3 Drug transport; 2.3.1 Transport mechanisms; 2.4 Permeability-absorption models; 2.4.1 Physicochemical methods; 2.4.1.1 Physicochemical factors; 2.4.1.2 Immobilized artificial membrane chromatography 
505 8 |a 2.4.1.3 Parallel artificial membrane permeability assay2.4.2 In vitro cell and tissue methods; 2.4.2.1 Cell-based methods; 2.4.2.2 Tissue-based methods; Diffusion chambers; Franz cells; Everted sacs; Isolated membrane vesicles; 2.5 Methods for permeability calculation; 2.6 Standardization of protocols for in vitro methods; 2.7 The "three Rs" principle; 2.8 Biosecurity systems; References; 3.1 -- Cell-based in vitro models for buccal permeability studies; 3.1.1 Introduction; 3.1.2 Physiology of the buccal mucosa; 3.1.3 Different in vitro models; 3.1.3.1 Hamster cheek pouch cells 
505 8 |a 3.1.3.2 TR146 cell line3.1.3.2.1 Protocol; Cell culture conditions; Permeability studies; 3.1.3.3 Human oral keratinocytes; 3.1.3.3.1 Protocol; Oral keratinocyte culture conditions; Culturing on dead de-epidermized dermis (DDED); Permeability studies; 3.1.3.4 MatTek EpiOral™; 3.1.3.4.1 Protocol; Cell culture conditions; Permeability studies; 3.1.4 Conclusions; References; 3.2 -- Cell-based in vitro models for gastric permeability studies; 3.2.1 The stomach as a natural barrier to absorption; 3.2.2 Gastric drug delivery; 3.2.2.1 Molecular absorption in the stomach 
505 8 |a 3.2.2.2 Physicochemical factors mediating stomach absorptive permeability3.2.3 Cellularized models of gastric permeability; 3.2.3.1 Protocol for establishing cellularized artificial models of the gastric wall; 3.2.4 Conclusions; Acknowledgments; References; 3.3 -- Cell-based in vitro models for intestinal permeability studies; 3.3.1 Anatomy and physiology of human small intestine; 3.3.1.1 Stromal-epithelial cross-talk; 3.3.2 Mechanisms of transport; 3.3.3 Intestinal barriers; 3.3.4 Intestinal in vitro models; 3.3.4.1 Caco-2 model; 3.3.4.1.1 Accelerated Caco-2 models 
505 8 |a 3.3.4.1.2 Alternatives to the Caco-2 model3.3.4.2 Caco-2/HT29-MTX model; 3.3.4.3 Caco-2/Raji B model; 3.3.4.4 Caco-2/HT29-MTX/Raji B; 3.3.4.5 Novel 3D in vitro models; 3.3.5 Validation studies; 3.3.6 Conclusions; References; 3.4 -- Cell-based in vitro models for nasal permeability studies; 3.4.1 Introduction; 3.4.2 Nasal primary cell culture models; 3.4.2.1 Sampling approaches and procedures; 3.4.2.2 HNE cell preparation and culture initiation; 3.4.3 Immortalized nasal cell lines; 3.4.3.1 RMPI 2650 cell line; 3.4.3.2 BT cell line; 3.4.3.3 Human lung carcinoma cell line 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
590 |a Knovel  |b Knovel (All titles) 
650 0 |a Drugs  |x Testing. 
650 0 |a Drugs  |x Physiological transport  |x Research  |x Methodology. 
650 0 |a Epithelial cells. 
650 0 |a Cell culture. 
650 0 |a Permeability. 
650 0 |a Pharmacokinetics. 
650 0 |a Biological models. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Sarmento, Bruno,  |e editor. 
776 0 8 |i Print version:  |z 9780081000946  |z 0081000944  |w (OCoLC)911073450 
830 0 |a Woodhead Publishing series in biomedicine ;  |v no. 79. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://app.knovel.com/hotlink/toc/id:kpCMDPSCTG/concepts-and-models?kpromoter=marc  |y Full text 

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