Sequence-specific DNA binding agents

The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by...

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Bibliographic Details
Other Authors Waring, Michael J.
Format Electronic eBook
LanguageEnglish
Published Cambridge : RSC Pub., ©2006.
SeriesRSC biomolecular sciences.
Subjects
DNA-drug interactions.
DNA-binding proteins.
Gene targeting.
Drug targeting.
Chemotherapy.
elektronické knihy
electronic books
Online AccessFull text
ISBN9781628701395
1628701390
1847555306
9781847555304
9780854043705
0854043705
Physical Description1 online resource (xi, 258 pages) : illustrations (some color)

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Table of Contents:
  • DNA recognition by triple helix formation / David A. Rusling, Tom Brown, and Keith R. Fox
  • Interfacial inhibitors of human topoisomerase I / Christophe Marchand and Yves Pommier
  • Diversity of topoisomerase I inhibitors for cancer chemotherapy / Nathalie Dias and Christian Bailly
  • Slow DNA binding / L. Marcus Wilhelmsson, Per Lincoln, and Bengt Nordén
  • DNA gene targeting using Peptide Nucleic Acid (PNA) / Peter E. Nielsen
  • Actinomycin D : sixty years of progress in characterizing a sequence-selective DNA-binding agent / David E. Graves
  • Thermal denaturation of drug-DNA complexes : tools and tricks / Jonathan B. Chaires and Xiaochun Shi
  • Computer simulations of drug-DNA interactions : a personal journey / Federico Gago
  • The discovery of G-quadruplex telomere targeting drugs / Stephen Neidle
  • The mechanism of action of telomestatin, a G-quadruplex-interactive compound / Daekyu Sun and Laurence H. Hurley
  • Structural features of the specific interactions between nucleic acids and small organic molecules / Alexander Serganov and Dinshaw J. Patel.

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