NMR spectroscopy in pharmaceutical analysis

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatograph...

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Bibliographic Details
Other Authors: Holzgrabe, U., Wawer, I., Diehl, B.
Format: eBook
Language: English
Published: Amsterdam ; Boston : Elsevier, ©2008.
Edition: 1st ed.
Subjects:
Nuclear magnetic resonance spectroscopy.
Drugs > Analysis.
Drugs > Design.
elektronické knihy
electronic books
ISBN: 9780080558196
0080558194
Physical Description: 1 online resource (xxi, 501 pages) : illustrations

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020 |a 9780080558196  |q (electronic bk.) 
020 |a 0080558194  |q (electronic bk.) 
035 |a (OCoLC)500897771  |z (OCoLC)968061758  |z (OCoLC)969014819  |z (OCoLC)1058138737 
245 0 0 |a NMR spectroscopy in pharmaceutical analysis /  |c edited by Ulrike Holzgrabe, Iwona Wawer, Bernd Diehl. 
250 |a 1st ed. 
260 |a Amsterdam ;  |a Boston :  |b Elsevier,  |c ©2008. 
300 |a 1 online resource (xxi, 501 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
505 0 |a pt. I. Fundamentals and techniques. Principles in NMR spectroscopy / B. Diehl ; Quantitative NMR in the solution state NMR / F. Malz ; qNMR in solid state / I. Wawer ; Microcoil nuclear magnetic resonance spectroscopy / A.G. Webb ; qNMR spectroscopy in drug analysis -- a general view / U. Holzgrabe -- pt. II. General applications. Investigation of multi-component drugs by NMR spectroscopy / T. Beyer and U. Holzgrabe ; NMR applications for polymer characterization / B. Diehl ; NMR spectroscopy of natural substances / B. Diehl ; Solid-state measurements of drugs and drug formulations / I. Wawer ; Metabolic profiling / K.A. Kaiser [and others] ; DOSY NMR for drug analysis / V. Gilard [and others] ; The use of qNMR for the analysis of agrochemicals / R.J. Wells, J. Cheung, and (in part) J.M. Hook -- pt. III. Special applications. NMR-based mixture analysis on the example of fruit juice quality control using statistics and quantification / M. Spraul [and others] ; NMR assays for carbohydrate-based vaccines / C. Jones and N. Ravenscroft ; Fluorine-19 or Phosphorus-31 NMR spectroscopy : a powerful technique for biofluid metabolic studies and pharmaceutical formulation analysis of fluorinated or phosphorylated drugs / R. Martino, V. Gilard, and M. Malet-Martino ; Quantitative 2D NMR analysis of glycosaminoglycans / G. Torri and M. Guerrini ; The use of proton NMR as an alternative for the amino acid analysis as identity test for peptides / E. Kellenbach, K. Sander, and P.L.A. Overbeeke ; Assessment of inhibitory potency of antibiotics by MRI / C. Faber ; Hypernation and concatenation : multiple on-line spectroscopic analysis for drug and natural product characterisation / I.D. Wilson ; Quantitative high-resolution online NMR spectroscopy in pharmaceutical reaction and process monitoring / M. Maiwald [and others]. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. . combines theory, techniques, and concrete applications-all of which closely resemble the laboratory experience . considers international pharmacopoeias, addressing the concern for licensing . features the work of academics and researchers, appealing to a broad readership. 
590 |a Knovel  |b Knovel (All titles) 
650 0 |a Nuclear magnetic resonance spectroscopy. 
650 0 |a Drugs  |x Analysis. 
650 0 |a Drugs  |x Design. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Holzgrabe, U.  |q (Ulrike)  |1 https://id.oclc.org/worldcat/entity/E39PBJwtkCvRtYDDgtybBJWhpP 
700 1 |a Wawer, I.  |q (Iwona)  |1 https://id.oclc.org/worldcat/entity/E39PCjJyYfMhFPycBGCKmRHxQq 
700 1 |a Diehl, B.  |q (Bernd)  |1 https://id.oclc.org/worldcat/entity/E39PCjHbMP9q4Yj9QkdDjMm8G3 
776 0 8 |i Print version:  |t NMR spectroscopy in pharmaceutical analysis.  |b 1st ed.  |d Amsterdam ; Boston : Elsevier, ©2008  |z 9780444531735  |w (OCoLC)227913511 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://app.knovel.com/hotlink/toc/id:kpNMRSPA06/nmr-spectroscopy-in?kpromoter=marc  |y Full text 

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