Evaluation of the linear-nonthreshold dose-response model for ionizing radiation.

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Bibliographic Details
Corporate Author: National Council on Radiation Protection and Measurements.
Format: eBook
Language: English
Published: Bethesda, Md. : National Council on Radiation Protection and Measurements, ©2001.
Series: NCRP report ; no. 136.
Subjects:
Radiation > Toxicology.
Low-level radiation > Dose-response relationship.
elektronické knihy
electronic books
ISBN: 092960069X
9780929600697
9781601194725
1601194722
Physical Description: 1 online resource (ix, 287 pages) : illustrations : digital, HTML and PDF files

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Table of contents

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041 7 |a eng  |2 iso639-3 
245 0 0 |a Evaluation of the linear-nonthreshold dose-response model for ionizing radiation. 
260 |a Bethesda, Md. :  |b National Council on Radiation Protection and Measurements,  |c ©2001. 
300 |a 1 online resource (ix, 287 pages) :  |b illustrations : digital, HTML and PDF files 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a NCRP report ;  |v no. 136 
500 |a "Issued June 4, 2001." 
500 |a "Recommendations of the National Council on Radiation Protection and Measurements." 
504 |a Includes bibliographical references (pages 212-263) and index. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 8 |a Annotation  |b New experimental and epidemiological findings include growing evidence of adaptive responses to small doses of radiation that may enhance the capacity of cells to withstand the effects of further radiation exposure, and new evidence concerning the possible nature of neoplastic initiation. Therefore, a committee of the National Council on Radiation Protection and Measurements reassesses the weight of scientific evidence for and against the linear-threshold dose-response model for determining safe levels of exposure to ionizing radiation. The report also considers associated policy implications. It finds no reason for rejecting the model. Annotation c. Book News, Inc., Portland, OR (booknews.com). 
505 0 |a Cover Page -- Preface -- Contents -- 1. Executive Summary -- 2. Introduction -- 3. Biophysical -- 3.1 Energy Deposition and Its Relevance to Questions of Low-Dose Response -- 3.1.1 Track Structure -- 3.1.2 Quantitative Characterization of Energy Deposition in Small Sites -- 3.1.3 Definition of Low Dose, Corresponding to an Average of One Energy Deposition Event per Target -- 3.2 Implications of Energy-Deposition Patterns for Independent Cellular Effects at Low Doses -- 3.3 Implications of Energy-Deposition Patterns for Carcinogenic Effects of Radiation 
505 8 |a 3.3.1 Evidence Regarding the Clonality of Tumors3.3.2 Relationship Between Initially-Damaged Cells and Tumorigenic Cells -- 3.4 Conclusions -- 3.5 Research Needs -- 4. Deoxyribonucleic Acid Repair and Processing after Low Doses and Low-Dose Rates of Ionizing Radiation -- 4.1 Ionizing Radiation-Induced DNA Lesions and Their Repair -- 4.1.1 Single-Strand Breaks (Including Deoxyribose Damage) -- 4.1.2 Base Damage and Loss -- 4.1.3 DNA-Protein Cross-Links -- 4.1.4 Double-Strand Breaks -- 4.1.5 Multiply-Damaged Sites -- 4.1.6 Mismatch Repair 
505 8 |a 4.1.7 Effects of Linear-Energy Transfer4.1.8 Spontaneous DNA Damage -- 4.2 Cell-Cycle Checkpoints -- 4.3 Programmed Cell Death (Apoptosis) -- 4.4 Impact of Cell-Cycle Checkpoints and Apoptosis on the Dose Response for DNA Repair at Low-Dose Rates -- 4.5 The Adaptive Response -- 4.6 Summary -- 4.7 Research Needs -- 5. Mutagenesis -- 5.1 Introduction -- 5.2 Potential Mechanisms of Mutagenesis -- 5.2.1 Replication Errors -- 5.2.2 Mutations Arising During Repair -- 5.3 Dose-Response Studies with Low Linear-Energy Transfer Radiation -- 5.3.1 Human in Vivo 
505 8 |a 5.3.2 Animal in Vivo5.3.3 Mammalian Cells in Vitro -- 5.4 Dose-Response Studies with High Linear-Energy Transfer Radiation -- 5.5 Summary -- 5.6 Research Needs -- 6. Chromosome Aberrations Induced by Low Doses and Low-Dose Rates of Ionizing Radiation -- 6.1 Misrepair, Misreplication, and Chromosome Aberration Formation -- 6.1.1 Chromosome-Type Aberrations -- 6.1.2 Chromatid-Type Aberrations -- 6.1.3 Mechanisms of Formation of Chromosome Aberrations -- 6.1.4 Dose-Response Curves: Acute and Chronic Exposures -- 6.2 Distribution of Aberrations Within and Among Cells 
505 8 |a 6.2.1 Intercellular Distributions of Chromosome Aberrations6.2.2 Inter- and Intrachromosomal Distribution of Chromosome Aberrations -- 6.3 Uncertainties in Shapes of Dose-Response Curves at Low Doses -- 6.3.1 Nonlinear and Threshold Responses -- 6.3.2 Effect of Adaptive Response -- 6.3.3 Efficiency of DNA Repair -- 6.3.4 Inducibility of DNA Repair and Cell-Cycle Checkpoints -- 6.3.5 Genomic Instability -- 6.4 Association Between Chromosomal Changes and Cancer -- 6.5 Biological Dosimetry for Chromosome Aberrations -- 6.5.1 Acute Exposures -- 6.5.2 Chronic Exposures 
590 |a Knovel  |b Knovel (All titles) 
650 0 |a Radiation  |x Toxicology. 
650 0 |a Low-level radiation  |x Dose-response relationship. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
710 2 |a National Council on Radiation Protection and Measurements. 
776 0 8 |i Print version:  |t Evaluation of the linear-nonthreshold dose-response model for ionizing radiation.  |d Bethesda, Md. : National Council on Radiation Protection and Measurements, ©2001  |z 092960069X  |w (OCoLC)46872314 
830 0 |a NCRP report ;  |v no. 136. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://app.knovel.com/hotlink/toc/id:kpELNDRMI2/evaluation-of-the?kpromoter=marc  |y Full text 

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