Fundamentals of MALDI-ToF-MS analysis : applications in bio-diagnosis, tissue engineering and drug delivery

This book presents the fundamentals and applications of Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF-MS) technique. It highlights the basic principles, the history of invention as well as the mechanism of ionization and mass determination using this techniq...

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Bibliographic Details
Main Authors: Hosseini, Samira, (Author), Martinez Chapa, Sergio Omar, (Author)
Format: eBook
Language: English
Published: Singapore : Springer, [2016]
Series: SpringerBriefs in applied sciences and technology. Forensic and medical bioinformatics.
Subjects:
Matrix-assisted laser desorption-ionization.
elektronické knihy
electronic books
ISBN: 9789811023569
9789811023552
Physical Description: 1 online resource (xi, 68 pages) : illustrations (some color)

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100 1 |a Hosseini, Samira,  |e author. 
245 1 0 |a Fundamentals of MALDI-ToF-MS analysis :  |b applications in bio-diagnosis, tissue engineering and drug delivery /  |c Samira Hosseini, Sergio O. Martinez-Chapa. 
264 1 |a Singapore :  |b Springer,  |c [2016] 
264 4 |c ©2017 
300 |a 1 online resource (xi, 68 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a SpringerBriefs in applied sciences and technology, Forensic and medical bioinformatics,  |x 2191-530X 
504 |a Includes bibliographical references. 
505 0 |a Preface; Acknowledgment; Contents; 1 Principles and Mechanism of MALDI-ToF-MS Analysis; Abstract; 1.1 Background of MALDI-ToF-MS; 1.2 Applications of MALDI-ToF-MS; 1.2.1 Biochemistry; 1.2.2 Organic Chemistry; 1.2.3 Polymer Chemistry; 1.2.4 Microbiology; 1.2.5 Medicine; 1.2.6 Nanotechnology; 1.3 Ionization Mechanism; 1.4 Time of Flight Mass Spectrometry Mechanism; 1.5 Detection Modes; 1.5.1 Linear Mode; 1.5.2 Reflection Mode; 1.6 Laser Range in MALDI; 1.7 Matrix Selection; 1.7.1 Limitations of Matrices; 1.8 Ionizing Agent Selection; 1.9 Fundamentals of Sample Preparation for MALDI Analysis. 
505 8 |a 1.9.1 Analyzable and Non-analyzable Polymers1.9.2 Sample Preparation Techniques; 1.9.2.1 Dried-Droplet; 1.9.2.2 Fast Crystallization; 1.9.2.3 Spin Coating; 1.9.2.4 Layer by Layer; 1.9.2.5 Electrospray Deposition; 1.10 Mass Discrimination; 1.10.1 Alternative Solutions for Overcoming Mass Discrimination; 1.11 MALDI Coupling; 1.11.1 Ion-Mobility Time of Flight Mass Spectrometry (IMS-ToF-MS); 1.11.2 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS); 1.11.3 Thin Layer Chromatography (TLC); 1.11.4 Size Exclusion Chromatograph (SEC); References. 
505 8 |a 2 Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic DomainAbstract; 2.1 Biosensors; 2.2 Synthesis of Poly Methyl Methacrylate-Co-Methacrylic Acid P(MMA-Co-MAA) and Preparation of the Biochips; 2.3 Sample Preparation for MALDI Analysis; 2.4 MALDI Data Interpretation; 2.4.1 Different Species as the Possible Products of Soft Ionization; 2.4.2 General Structure of P(MMA-Co-MAA); 2.4.3 MALDI Analysis of PMMA; 2.4.4 MALDI Analysis of P(MMA-Co-MAA); 2.4.5 End-Group Analysis; 2.5 Role of MALDI Analysis in Bio-sensing Application of P(MMA-Co-MAA); 2.5.1 Reaction's Parameters. 
505 8 |a 2.5.2 Chemistry Aspect2.5.3 Physical Aspect; References; 3 Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials; Abstract; 3.1 Tissue Engineering; 3.2 Synthesis of Poly Octanediol Citrate Acid-Sebacate Acid P(OCS) and Preparation of the Scaffold; 3.3 MALDI Analysis of P(OCS) and Sample Preparation; 3.4 MALDI Data Interpretation; 3.5 Role of MALDI Analysis in Tissue Engineering Application of P(OCS); 3.5.1 Reaction's Parameters; 3.5.2 Chemistry Aspect; 3.5.3 Mechanical Aspect; References. 
505 8 |a 4 Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug DeliveryAbstract; 4.1 Drug Delivery; 4.2 Synthesis of PCLT-CA and Preparation of Elastomeric Films and Coatings; 4.3 Sample Preparation for MALDI Analysis; 4.4 MALDI Data Interpretation; 4.5 The Role of MALDI Analysis in Drug Delivery Application of PCLT-CA; 4.5.1 Chemistry Aspect; 4.5.2 Mechanical Aspect; References; Summary. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book presents the fundamentals and applications of Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF-MS) technique. It highlights the basic principles, the history of invention as well as the mechanism of ionization and mass determination using this technique. It describes the fundamental principles and methods for MALDI spectra interpretation and determination of exact chemical structures from experimental data. This book guides the reader through the interpretation of MALDI data where complex macromolecular spectra are simplified in order to present the major principles behind data interpretation. In addition, each chapter describes how MALDI-ToF-MS analysis provides necessary understanding of the copolymer systems that have been designed for specialized biomedical applications. 
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700 1 |a Martinez Chapa, Sergio Omar,  |e author. 
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830 0 |a SpringerBriefs in applied sciences and technology.  |p Forensic and medical bioinformatics. 
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