Membrane organization and dynamics

• Other Authors: Chattopadhyay, Amitabha, 1956- (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham, Switzerland : Springer, 2017.
• Series: Springer series in biophysics ; v. 20.
• Subjects: Membranes (Biology) > Mechanical properties.; elektronické knihy; electronic books
• ISBN: 9783319666013; 9783319666006
• Physical Description: 1 online resource

This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contempora...

Table of Contents:

• Intro; Preface; Contents; About the Editor; Chapter 1: What Is So Unique About Biomembrane Organization and Dynamics?; 1.1 Cellular Membranes as Identity Markers; 1.2 What Holds the Membrane Together?; 1.3 Unique Features of Biomembrane Organization and Dynamics; 1.4 Spatiotemporal Scales of Membrane Phenomena; 1.5 Future Perspectives: What Lies Ahead; References; Chapter 2: Dynamics and Organization of Archaeal Tetraether Lipid Membranes; 2.1 Chemical Structures of Bipolar Tetraether Lipids; 2.1.1 Bipolar Tetraether Lipids Isolated from Archaea
• 2.1.2 Synthetic Bipolar Tetraether Lipid Analogues2.2 BTL Membranes; 2.3 Stability of BTL Membranes; 2.4 Phase Behaviors of BTL Membranes; 2.5 Membrane Lateral Diffusion; 2.6 Probe Rotations and Insertion in BTL Membranes; 2.7 Gradient of Membrane Dynamics Along the Membrane Normal; 2.8 Solute Permeation in BTL Membranes; 2.9 Role of Sugar Moieties in BTL Membrane Physical Properties; 2.10 Lateral Organization in BTL Membranes; 2.11 Concluding Remarks; References; Chapter 3: Effects of Oxidative Stress, Hyperglycemia, and Hypercholesterolemia on Membrane Structural Organization and the In ...
• 3.1 Cholesterol Is an Important Component of Cellular Membranes3.2 Effects of Oxidation, Hyperglycemia, and Hypercholesterolemia on Cellular Membranes; 3.3 Effects of Omega-3 Long Chain Polyunsaturated Acids on Membranes; 3.4 Differential Effects of Fatty Acids: EPA and DHA; 3.5 Summary; References; Chapter 4: Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation; 4.1 Experimental Approaches to Characterize the Interaction Between Small Molecules and Lipid Bilayers
• 4.1.1 Solutes with High Solubility in the Aqueous Media and Insoluble in the Lipid Bilayer4.1.2 Solutes with a Moderate Solubility in the Aqueous Media and in the Lipid Bilayer; 4.1.3 Solutes with Very Low Solubility in the Aqueous Media and a High Partition into the Lipid Bilayer; 4.2 Molecular Dynamics Simulations to Characterize the Interaction and Permeation of Small Molecules Through Lipid Bilayers; 4.2.1 General Description on the Generation of the PMF Profile Through Lipid Bilayers; 4.2.2 The General Simulation Protocol; 4.2.3 Sampling Issues
• 4.2.4 The General Description of the PMF Profile4.2.5 How to Obtain Kinetics from the PMF; 4.2.6 Calculation of Permeability Coefficients from MD Simulations; 4.3 Concluding Remarks; References; Chapter 5: Multidimensional Microscopy: Application to Membrane Protein Structure; 5.1 Introduction; 5.2 Formalism; 5.3 An Archetypical Membrane Protein: The Epidermal Growth Factor Receptor; 5.4 Multidimensional Microscopy of EGFR on Intact Cells; 5.4.1 In-Cell Quaternary Structure of EGFR in the Absence of EGF (ICS, Polarization, FCS)