Uptake and trafficking of protein toxins

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium...

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Bibliographic Details
Other Authors Barth, Holger, 1965- (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, [2017]
SeriesCurrent topics in microbiology and immunology ; v. 406.
Subjects
Bacterial toxins.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319588933
9783319588919
ISSN0070-217X ;
Physical Description1 online resource (vii, 256 pages) : illustrations (some color)

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Table of Contents:
  • Two feet on the membrane: uptake of clostridial neurotoxins
  • Receptors and binding structures for Clostridium difficile Toxins A and B
  • Cell entry of C3 exoenzyme from Clostridium botulinum.- Receptor-binding and up-take of binary actin-ADP-ribosylating toxins
  • Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal "Coup de Grace"
  • Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins
  • Multivalent Inhibitors of Channel-Forming Bacterial Toxins
  • Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules.

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