Mitochondrial DNA and diseases
The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the signific...
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| Other Authors: | , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Singapore :
Springer,
2017.
|
| Series: | Advances in experimental medicine and biology ;
v. 1038. |
| Subjects: | |
| ISBN: | 9789811066740 9789811066733 |
| Physical Description: | 1 online resource (233 pages) |
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Table of contents
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| 245 | 0 | 0 | |a Mitochondrial DNA and diseases / |c Hongzhi Sun, Xiangdong Wang, editors. |
| 260 | |a Singapore : |b Springer, |c 2017. | ||
| 300 | |a 1 online resource (233 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a počítač |b c |2 rdamedia | ||
| 338 | |a online zdroj |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in Experimental Medicine and Biology ; |v v. 1038 | |
| 505 | 0 | |a How far can mitochondrial DNA drive the disease? -- Mitochondrial DNA in lung cancer -- Approach, application and bioethics of mtDNA sequencing in cancer -- Roles of mitochondrial DNA signaling in immune responses -- Mitochondrial DNA in Telocytes -- Roles of mitochondrial DNA in energy metabolism -- The role of base excision repair in maintaining mitochondrial DNA stability.- Is mitochondrial cell fragility a cell weakness? -- Mitochondrial DNA methylation and related disease -- Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis -- Metabolic regulation in mitochondria and drug resistance.- Mitochondrial Lon Protease and Cancer -- Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease. | |
| 506 | |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty | ||
| 520 | |a The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA-associated diseases. | ||
| 504 | |a Includes bibliographical references. | ||
| 590 | |a SpringerLink |b Springer Complete eBooks | ||
| 650 | 0 | |a Mitochondrial DNA. | |
| 650 | 0 | |a Mitochondrial DNA |x Abnormalities. | |
| 655 | 7 | |a elektronické knihy |7 fd186907 |2 czenas | |
| 655 | 9 | |a electronic books |2 eczenas | |
| 700 | 1 | |a Sun, Hongzhi. | |
| 700 | 1 | |a Wang, Xiangdong |c (Professor of clinical bioinformatics) | |
| 776 | 0 | 8 | |i Print version: |a Sun, Hongzhi. |t Mitochondrial DNA and Diseases. |d Singapore : Springer Singapore Pte. Limited, ©2017 |z 9789811066733 |
| 830 | 0 | |a Advances in experimental medicine and biology ; |v v. 1038. | |
| 856 | 4 | 0 | |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-981-10-6674-0 |y Plný text |
| 992 | |c NTK-SpringerBLS | ||
| 999 | |c 97662 |d 97662 | ||
| 993 | |x NEPOSILAT |y EIZ | ||
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