Emerging concepts targeting immune checkpoints in cancer and autoimmunity

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules...

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Bibliographic Details
Other Authors Yoshimura, Akihiko
Format Electronic eBook
LanguageEnglish
Published Cham : Springer, 2017.
SeriesCurrent topics in microbiology and immunology ; 410.
Subjects
Immune response > Regulation.
Cancer > Immunological aspects.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319689296
9783319689289
Physical Description1 online resource (268 pages)

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Table of Contents:
  • Regulatory T cells: molecular and cellular basis for immunoregulation
  • Overview of LAG-3- expressing, IL-10-producing regulatory T cells
  • Regulatory Dendritic Cells
  • Role of PD-1 in immunity and diseases
  • CTLA-4, an essential immune-checkpoint for T cell activation
  • Tim-3, Lag-3, and TIGIT
  • SOCS1: regulator of T cells in autoimmunity and cancer
  • Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity
  • Immune regulation by ubiquitin tagging as checkpoint code
  • MicroRNA in Immune Regulation.

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