DJ-1/PARK7 protein : Parkinson's disease, cancer and oxidative stress-induced diseases

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of...

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Bibliographic Details
Other Authors Ariga, Hiroyoshi (Editor), Iguchi-Ariga, Sanae M. M. (Editor)
Format Electronic eBook
LanguageEnglish
Published Singapore : Springer, 2017.
SeriesAdvances in experimental medicine and biology ; v. 1037.
Subjects
Proteins.
Nervous system > Degeneration > Molecular aspects.
Cancer > Molecular aspects.
elektronické knihy
electronic books
Online AccessFull text
ISBN9789811065835
9789811065828
ISSN2214-8019 ;
Physical Description1 online resource (224 pages)

Cover

Table of Contents:
  • Preface.- Chapter 1 Introduction/Overview
  • Chapter 2 Structural Biology of the DJ-1 Superfamily
  • Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases
  • Chapter 4 DJ-1 as an oncogene and its clinical significance
  • Chapter 5 Role of DJ-1 in fertilization
  • Chapter 6 Anti-oxidative stress function of DJ-1
  • Chapter 7 Ttranscriptional regulation of DJ-1
  • Chapter 8 Regulation of Signal Transduction by DJ-1
  • Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal
  • Chapter 10 DJ-1 as a biomarker of Parkinson's disease
  • Chapter 11 Roles of DJ-1 in diabetes mellitus
  • Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases
  • Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy.
  • Introduction/overview
  • Structural biology of the DJ-1 superfamily
  • Expression of DJ-1 in patients with neurodegenerative diseases
  • DJ-1 as an oncogene and its clinical significance
  • Role of DJ-1 in fertilization
  • Anti-oxidative stress function of DJ-1
  • Transcriptional regulation of DJ-1
  • Regulation of signal transduction by DJ-1
  • Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal
  • DJ-1 as a biomarker of Parkinson's disease
  • Roles of DJ-1 in diabetes mellitus
  • Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases
  • DJ-1 as an oncogene and promising target for cancer chemotherapy.

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