Inflammation and angiogenesis

This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the pro...

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Bibliographic Details
Main Author: Ribatti, Domenico.
Format: eBook
Language: English
Published: Cham : Springer, 2017.
Subjects:
Inflammation.
Neovascularization.
elektronické knihy
electronic books
ISBN: 9783319684482
9783319684475
Physical Description: 1 online resource

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100 1 |a Ribatti, Domenico. 
245 1 0 |a Inflammation and angiogenesis /  |c Domenico Ribatti. 
264 1 |a Cham :  |b Springer,  |c 2017. 
300 |a 1 online resource 
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506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter. 
505 0 |a Abstract -- Contents -- Chapter 1: Introduction -- Chapter 2: The Importance of Microenvironment in Tumor Metastasis -- Chapter 3: Immune Cells -- Chapter 4: Lymphocyte Homing -- Chapter 5: Inflammation and Cancer -- 5.1 The Relationship Between the Immune System Surveillance and Cancer -- 5.2 Immunoediting, a New Approach -- 5.3 Current Approaches in Anti-tumor Immunotherapy -- Chapter 6: Inflammation and Angiogenesis -- Chapter 7: The Contribution of Immune Cells to Angiogenesis in Inflammation and Tumor Growth -- 7.1 Neutrophils 
505 8 |a 7.1.1 Neutrophils, Angiogenesis, and Inflammation7.2 Monocytes-Macrophages -- 7.2.1 Monocytes/Macrophages, Angiogenesis, and Inflammation -- 7.2.2 Transdifferentation of Monocytes/Macrophages in Endothelial Cells and Tie-2 Monocytes -- 7.2.3 Therapeutic Strategies -- 7.3 Tie-2 Expressing Monocytes (TEMs) -- 7.4 Lymphocytes -- 7.4.1 Lymphocytes, Angiogenesis and Inflammation -- 7.5 Dendritic Cells -- 7.6 Mast Cells -- 7.6.1 Mast Cells, Angiogenesis, and Chronic Inflammation -- 7.6.2 Therapeutic Strategies -- 7.7 Eosinophils 
505 8 |a 7.7.1 Mast Cells and Eosinophils in Angiogenesis During Allergic Diseases7.8 Basophils -- 7.9 Progenitor Cells and Adult Cell Transdifferentiation -- 7.10 Platelets -- 7.11 Fibroblasts -- 7.11.1 Therapeutic Strategies -- Chapter 8: Conclusions -- References 
504 |a Includes bibliographical references (pages 87-110) and index. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Inflammation. 
650 0 |a Neovascularization. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
776 0 8 |i Print version:  |a Ribatti, Domenico.  |t Inflammation and Angiogenesis.  |d Cham : Springer International Publishing, ©2017  |z 9783319684475 
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