Chromogranins : from cell biology to physiology and biomedicine

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, h...

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Bibliographic Details
Other Authors Angelone, Tommaso, Cerra, Maria Carmela, Tota, Bruno
Format Electronic eBook
LanguageEnglish
Published Cham : Springer, 2017.
SeriesUNIPA Springer series.
Subjects
Chromogranins.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319583389
9783319583372
Physical Description1 online resource (271 pages)

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Table of Contents:
  • Contents
  • Contributors
  • History and Perspectives
  • 1 History
  • 1.1 The First Hundred Years of the Chromaffin Cells
  • 1.2 The First Decade of the Chromaffin Granules
  • 1.3 The First Thirty Five Years of the Granins
  • 1.3.1 Glucose Homeostasis, Pancreastatin and the Prohormone Concept
  • 1.3.2 Calcium Homeostasis and the N-Terminus of CgA
  • 1.4 The Granins and their Derived Peptides
  • 1.4.1 The Antimicrobial Peptides and Innate Immunity
  • 1.5 Functional and Clinical Aspects
  • 1.5.1 Vasostatins, Vasodilations, the Vascular Endothelium and Angiogenesis1.5.2 Vasostatins, Catestatin and Serpinin; Myocardial Contractility and Protection against Ischemia-Induced Injury
  • 1.5.3 Angiogenesis, Cell Adhesion and Tumor Progression
  • 1.5.4 A Physiological Role for the Circulating CgA
  • 1.5.5 Circulating CgA as a Marker for Inflammatory Diseases
  • 1.6 Putative Receptors for CgA and CgA-Derived Peptides
  • 2 Conclusions
  • 3 Perspectives
  • References
  • Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin1 Introduction
  • 2 Structure & Posttranslational Modifications of Secretogranin II
  • 3 Subcellular Localization
  • 4 Tissue Expression and Secretion from Cells
  • 5 Phylogenetic Conservation of Secretogranin II
  • 6 Gene Organisation and Gene Regulation
  • 7 Biomarker and Disease
  • 7.1 Tumors
  • 7.2 CNS Diseases
  • 7.3 Heart Failure
  • 8 Physiologic Function of Secretogranin II
  • 8.1 Biogenesis of Secretory Granules
  • 8.2 Sorting and Release of Secretory Proteins8.3 Precursor of the Neuropeptide/Cytokine Secretoneurin
  • 8.3.1 Angiogenesis and Vasculogenesis
  • 8.3.2 Wound Healing
  • 8.3.3 Effects of SN on Cerebral Ischemia
  • 8.3.4 Effects of SN on Cardiomyocytes
  • 8.3.5 Effects of SN Gene Therapy on Animal Models of High Vascular Risk
  • References
  • Chromogranins as Molecular Coordinators at the Crossroads between Hormone Aggregation and Secretory Granule Biogenesis
  • 1 Introduction
  • 2 I/ The Twenty-First Century, the Advent of Chromogranins as Critical Regulators of Secretory Granule Biogenesis3 II/ Hormone Aggregation as the First Function Assigned to Chromogranins
  • 4 III/ Hormone Sorting through Interaction of Chromogranins with the TGN Membrane
  • 5 IV/ Are Chromogranins Linked to Hypersecretory Endocrine Pathologies?
  • 6 Concluding Remarks
  • References
  • Involvement of Chromogranin A and Its Derived Peptides to Fight Infections
  • 1 Innate Immunity and Antimicrobial Peptides

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