Cardiac regeneration

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, progr...

Full description

Saved in:
Bibliographic Details
Other Authors Ieda, Masaki (Editor), Zimmermann, Wolfram-Hubertus (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham : Springer, 2017.
SeriesCardiac and vascular biology.
Subjects
Cardiology.
Heart > Diseases > Treatment.
Regenerative medicine.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319561066
9783319561042
Physical Description1 online resource

Cover

Table of Contents:
  • Preface
  • Contents
  • 1: Past and Future of Cell-Based Heart Repair
  • 1.1 Introduction
  • 1.2 Cell Therapy for Cardiac Repair
  • 1.2.1 Skeletal Myoblasts
  • 1.2.2 Bone Marrow-Derived Stem Cells
  • 1.2.3 Endothelial Progenitors
  • 1.2.4 Mesenchymal Stem Cells
  • 1.2.5 Endogenous Cardiac Stem Cells
  • 1.2.5.1 C-kit + Cardiac Progenitors
  • 1.2.5.2 Cardiosphere and Cardiosphere-Derived Cells
  • 1.2.5.3 Side Population Cells
  • 1.2.5.4 Sca1+ Cardiac Progenitors
  • 1.2.5.5 Islet1+ Cardiac Progenitors
  • 1.2.5.6 Epicardial Progenitors
  • 1.2.6 ES-Derived Cardiomyocytes1.2.7 Induced Pluripotent Stem Cells and Reprogramming
  • 1.2.7.1 iPSCs
  • 1.2.7.2 Direct Reprogramming into Cardiomyocytes
  • 1.3 Future of Cell Therapy
  • References
  • 2: Progenitor Cells from the Adult Heart
  • 2.1 Phenotype and Characteristics of eCSCs
  • 2.1.1 c-kitpos Stem and Progenitor Cells
  • 2.1.2 Sca-1pos and Side Population Progenitor Cells
  • 2.2 Cardiac Differentiation Potential of eCSCs
  • 2.3 The Controversy
  • 2.4 Origin of eCSCs
  • 2.5 Impact of Ageing and Senescence on eCSCs
  • 2.6 Therapeutic Targets to Activate eCSCs and Reverse the Senescent, Dysfunctional eCSC PhenotypeReferences
  • 3: Epicardial Progenitors in the Embryonic and Adult Heart
  • 3.1 Epicardial Development Across Species
  • 3.2 EPDC Derivatives and Epicardial Heterogeneity
  • 3.2.1 Epicardium Contribution to Coronary Endothelial Cells
  • 3.2.2 Epicardial Contribution to Cardiomyocytes
  • 3.2.3 Epicardial Contribution to Fat Cells
  • 3.3 The Epicardium as a Signaling Center in the Developing Heart
  • 3.3.1 Epicardial Signals Promoting Cardiomyocyte Proliferation3.3.2 Epicardial Signals Directing Coronary Angiogenesis
  • 3.3.3 Other Epicardial Signals Contributing to Heart Development
  • 3.4 Adult Epicardium
  • 3.4.1 Physiological Role of the Epicardium in Homeostatic Conditions
  • 3.4.2 The Epicardium to Regenerate the Adult Heart
  • 3.5 Human Epicardium
  • References
  • 4: Generation and Application of Human Pluripotent Stem Cell-Derived Cardiomyocytes
  • 4.1 Introduction
  • 4.2 Applications
  • 4.2.1 Regenerative Medicine
  • 4.2.2 Biological Pacemaker Development4.2.3 Understanding of Human Cardiac Development
  • 4.2.4 Disease Modeling
  • 4.2.5 Drug Discovery, Pharmacogenomics, and Cardiotoxicity Screening
  • 4.3 Cardiomyogenesis during Mammalian Heart Development
  • 4.4 Control of the Pluripotent State
  • 4.5 Human Pluripotent Growth Media
  • 4.6 Priming for Cardiac Differentiation
  • 4.7 Maintenance of hiPSC-Derived Mesodermal Intermediates and Cardiac Progenitor Cells
  • 4.8 Directed Cardiac Differentiation of Human Pluripotent Stem Cells

Similar Items