Cardiac regeneration

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, progr...

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Bibliographic Details
Other Authors Ieda, Masaki (Editor), Zimmermann, Wolfram-Hubertus (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham : Springer, 2017.
SeriesCardiac and vascular biology.
Subjects
Cardiology.
Heart > Diseases > Treatment.
Regenerative medicine.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319561066
9783319561042
Physical Description1 online resource

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245 0 0 |a Cardiac regeneration /  |c Masaki Ieda, Wolfram-Hubertus Zimmermann, editors. 
264 1 |a Cham :  |b Springer,  |c 2017. 
300 |a 1 online resource 
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490 1 |a Cardiac and vascular biology 
504 |a Includes bibliographical references. 
505 0 |a Preface -- Contents -- 1: Past and Future of Cell-Based Heart Repair -- 1.1 Introduction -- 1.2 Cell Therapy for Cardiac Repair -- 1.2.1 Skeletal Myoblasts -- 1.2.2 Bone Marrow-Derived Stem Cells -- 1.2.3 Endothelial Progenitors -- 1.2.4 Mesenchymal Stem Cells -- 1.2.5 Endogenous Cardiac Stem Cells -- 1.2.5.1 C-kit + Cardiac Progenitors -- 1.2.5.2 Cardiosphere and Cardiosphere-Derived Cells -- 1.2.5.3 Side Population Cells -- 1.2.5.4 Sca1+ Cardiac Progenitors -- 1.2.5.5 Islet1+ Cardiac Progenitors -- 1.2.5.6 Epicardial Progenitors 
505 8 |a 1.2.6 ES-Derived Cardiomyocytes1.2.7 Induced Pluripotent Stem Cells and Reprogramming -- 1.2.7.1 iPSCs -- 1.2.7.2 Direct Reprogramming into Cardiomyocytes -- 1.3 Future of Cell Therapy -- References -- 2: Progenitor Cells from the Adult Heart -- 2.1 Phenotype and Characteristics of eCSCs -- 2.1.1 c-kitpos Stem and Progenitor Cells -- 2.1.2 Sca-1pos and Side Population Progenitor Cells -- 2.2 Cardiac Differentiation Potential of eCSCs -- 2.3 The Controversy -- 2.4 Origin of eCSCs -- 2.5 Impact of Ageing and Senescence on eCSCs 
505 8 |a 2.6 Therapeutic Targets to Activate eCSCs and Reverse the Senescent, Dysfunctional eCSC PhenotypeReferences -- 3: Epicardial Progenitors in the Embryonic and Adult Heart -- 3.1 Epicardial Development Across Species -- 3.2 EPDC Derivatives and Epicardial Heterogeneity -- 3.2.1 Epicardium Contribution to Coronary Endothelial Cells -- 3.2.2 Epicardial Contribution to Cardiomyocytes -- 3.2.3 Epicardial Contribution to Fat Cells -- 3.3 The Epicardium as a Signaling Center in the Developing Heart 
505 8 |a 3.3.1 Epicardial Signals Promoting Cardiomyocyte Proliferation3.3.2 Epicardial Signals Directing Coronary Angiogenesis -- 3.3.3 Other Epicardial Signals Contributing to Heart Development -- 3.4 Adult Epicardium -- 3.4.1 Physiological Role of the Epicardium in Homeostatic Conditions -- 3.4.2 The Epicardium to Regenerate the Adult Heart -- 3.5 Human Epicardium -- References -- 4: Generation and Application of Human Pluripotent Stem Cell-Derived Cardiomyocytes -- 4.1 Introduction -- 4.2 Applications -- 4.2.1 Regenerative Medicine 
505 8 |a 4.2.2 Biological Pacemaker Development4.2.3 Understanding of Human Cardiac Development -- 4.2.4 Disease Modeling -- 4.2.5 Drug Discovery, Pharmacogenomics, and Cardiotoxicity Screening -- 4.3 Cardiomyogenesis during Mammalian Heart Development -- 4.4 Control of the Pluripotent State -- 4.5 Human Pluripotent Growth Media -- 4.6 Priming for Cardiac Differentiation -- 4.7 Maintenance of hiPSC-Derived Mesodermal Intermediates and Cardiac Progenitor Cells -- 4.8 Directed Cardiac Differentiation of Human Pluripotent Stem Cells 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. 
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700 1 |a Ieda, Masaki,  |e editor. 
700 1 |a Zimmermann, Wolfram-Hubertus,  |e editor. 
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