Circadian rhythms and their impact on aging

This book examines the role of circadian rhythms in aging, an emerging area of biology. Although implicated in aging and longevity for over forty years, the richness of the ways in which the circadian system impacts aging has become evident only more recently. The circadian system consists of a cent...

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Bibliographic Details
Other Authors Jazwinski, S. Michal (Editor), Belancio, Victoria P. (Editor), Hill, Steve M. (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, ©2017.
SeriesHealthy ageing and longevity ; v. 7.
Subjects
Circadian rhythms.
Aging.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319645438
9783319645421
Physical Description1 online resource : illustrations

Cover

Table of Contents:
  • Contents
  • Introduction
  • 1 Circadian Dysregulation and Melatonin Rhythm Suppression in the Context of Aging
  • Abstract
  • 1.1 Introduction
  • 1.2 Hallmarks of Aging: Effects of Melatonin
  • 1.3 Consequences of Disruption of Circadian Rhythms
  • 1.4 Cellular Aging: The Case of Stem Cell Senescence
  • 1.5 Circadian Disruption and Age-Related Diseases
  • 1.6 Concluding Remarks and Perspectives
  • References
  • 2 Pulmonary Diseases, a Matter of Time
  • Abstract
  • 2.1 Introduction
  • 2.2 Chronobiology of the Lung
  • 2.3 A Time for Pulmonary Diseases
  • 2.3.1 Chronic Obstructive Pulmonary Disease (COPD)2.3.2 Idiopathic Pulmonary Fibrosis (IPF)
  • 2.3.3 Obstructive Sleep Apnea (OSA)
  • 2.3.4 Infectious Disease and Vaccine Efficacy in the Elderly
  • 2.3.5 Lung Cancer
  • 2.3.6 Asthma
  • 2.4 The Circadian Clock Regulates the Markers of Aging. Implications for the Pathophysiology of Age-Related Lung Disease
  • 2.4.1 Telomere Attrition
  • 2.4.2 Genomic Instability
  • 2.4.3 Epigenetic Alterations
  • 2.4.4 Loss of Proteostasis
  • 2.4.5 Deregulated Nutrient Sensing
  • 2.4.6 Mitochondrial Dysfunction and Oxidative Stress
  • 2.4.7 Cellular Senescence2.4.8 Stem Cell Exhaustion
  • 2.4.9 Intercellular Communication
  • 2.5 Chrono-Therapy for Age-Related Lung Diseases
  • 2.6 Future Directions
  • Acknowledgements
  • References
  • 3 Circadian Regulation of Bone
  • Abstract
  • 3.1 Introduction
  • 3.2 Circadian Rhythms and Bone
  • 3.2.1 Circadian Regulation of Clock Genes Expressed in Bone
  • 3.2.2 Circadian Regulation of Osteoblast- and Osteoclast-Specific Genes
  • 3.2.3 Mechanisms Underlying Clock-Mediated Regulation of Bone
  • 3.3 Humoral Effects of Bone Rhythms: Melatonin, Estrogen and Cortisol3.3.1 Melatonin Effects on Bone and Bone Rhythms
  • 3.3.2 Estrogen and Progesterone Effects on Bone and Bone Rhythms
  • 3.3.3 Cortisol Effects on Bone and Bone Rhythms
  • 3.3.3.1 Circadian Variation of Cortisol and Glucocorticoid Signaling in Bone
  • 3.3.3.2 Cortisol Effects on Clock Genes Expressed in Osteoblasts and Osteoclasts
  • 3.3.3.3 Effect of Lifestyle, Light Exposure and Environment on Cortisol Levels
  • 3.4 Strategies to Prevent Bone Loss Caused by Circadian Disruption
  • References
  • 4 Aging and the Circadian Control of the Gastrointestinal System: From the Brain to the Gut Microbiome (and Back)Abstract
  • 4.1 Introduction
  • 4.2 Peripheral Circadian Clocks and the Gastrointestinal System
  • 4.3 Aging and Circadian Clocks
  • 4.4 Gastrointestinal Melatonin
  • 4.5 Aging, Circadian Rhythms, and the Gastrointestinal Microbiome
  • 4.6 Conclusion and Prospectus
  • Acknowledgements
  • References
  • 5 Circadian System and Aging in Rodent Models
  • Abstract
  • 5.1 Introduction
  • 5.2 Mammalian Circadian System

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