Formaldehyde and cognition

This book introduces important, new knowledge regarding formaldehyde, especially endogenous formaldehyde, revealing its many key roles in the human body. It reviews the relationship between endogenous formaldehyde and cognition as well as age-related cognitive impairment, by discussing different asp...

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Bibliographic Details
Main Author He, Rongqiao (Author)
Format Electronic eBook
LanguageEnglish
Published Dordrecht, the Netherlands : Springer, [2017]
Subjects
Formaldehyde > Effectiveness.
Cognition.
elektronické knihy
electronic books
Online AccessFull text
ISBN9789402411775
9789402411751
Physical Description1 online resource

Cover

Table of Contents:
  • Preface
  • References
  • Contents
  • Chapter 1: Formaldehyde from Environment
  • 1 Introduction
  • 2 Formaldehyde Sources
  • 2.1 Natural Sources of Formaldehyde
  • 2.2 Anthropogenic Sources of Formaldehyde
  • 3 Formaldehyde Inhalation Exposure
  • 3.1 Indoor Formaldehyde Inhalation Exposure
  • 3.1.1 Indoor Residential Formaldehyde Exposure
  • 3.1.2 Indoor Office Exposure
  • 3.1.3 Indoor Public Exposure
  • 3.1.4 Indoor Occupational Exposure
  • 3.2 Outdoor Air Exposure
  • 4 Dietary Exposure of Formaldehyde
  • 5 Formaldehyde Exposure and Health Problems
  • 5.1 Acute Toxicosis5.2 Impairment and Symptoms of Intoxication
  • 6 Formaldehyde in Biological Evolution and Metabolism
  • 6.1 The Role of Formaldehyde in Biological Evolution
  • 6.2 The Metabolism of Formaldehyde
  • 7 Conclusion
  • References
  • Chapter 2: Metabolism of Formaldehyde In Vivo
  • 1 Introduction
  • 2 Endogenous Formaldehyde Generation
  • 2.1 From Environment
  • 2.2 From Food
  • 2.3 Formaldehyde in One-Carbon Circle
  • 2.4 Formaldehyde from Biochemical Compounds
  • 2.4.1 From Protein Denaturation
  • 2.4.2 From Lipid Oxidation
  • 2.4.3 From Reducing Sugar Decomposition2.4.4 Formaldehyde from Dimethylaminoethanol, Dimethylglycine, and Sarcosine (N-Methylglycine)
  • 2.4.5 From Substrates Containing the CH3N or CH3O Group Mediated by Cytochrome P-450 System
  • 2.5 Oxidative Stress Produces Formaldehyde
  • 2.5.1 SSAO Catalyzes Methylamine to Generate Formaldehyde
  • 2.5.2 Formaldehyde from Glycine Oxidation by MPO
  • 2.5.3 Cells Produce Reactive Oxygen Species (ROS) in the Presence of Formaldehyde and Vice Versa
  • 2.6 From Intestinal Flora
  • 2.7 From Oxidative Demethylation
  • 3 Formaldehyde Metabolic Pathways3.1 Mitochondrial ALDH2 Pathway
  • 3.2 Glutathione (GSH)-Dependent Pathway
  • 3.3 Intestinal Microbiota
  • 3.4 Synthesis of THF
  • 3.5 Reaction with Biomacromolecules Such as Protein, DNA, and RNA
  • 3.5.1 The Reaction Between Formaldehyde and Proteins
  • 3.5.2 The Reaction Between Formaldehyde and Nucleic Acids
  • 3.5.3 The Cross-Links of Proteins and Nucleic Acids Induced by Formaldehyde
  • 4 Conclusion
  • References
  • Chapter 3: Formaldehyde Playing a Role in (De)methylation for Memory
  • 1 Introduction
  • 2 Formaldehyde Plays a Role in DNA Methylation and Demethylation3 Formaldehyde and RNA Methylation/Demethylation
  • 4 Formaldehyde Is Also Active in Histone Methylation/Demethylation
  • 5 Methylation and Demethylation and Memory
  • 6 Formaldehyde Acting as an Epigenetic Factor in Formation and Loss of Memory
  • 7 Conclusion
  • References
  • Chapter 4: Dehydration, Formaldehyde, and Age-Related Cognitive Impairment
  • 1 Introduction
  • 2 A Progressive Dehydration as Aging
  • 3 Diminished Thirst Sensation as Aging

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