Pulmonary vasculature redox signaling in health and disease

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators wi...

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Bibliographic Details
Other Authors: Wang, Yong-Xiao, (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, 2017.
Series: Advances in experimental medicine and biology ; v. 967.
Subjects:
Active oxygen > Physiological effect.
Oxidation, Physiological.
elektronické knihy
electronic books
ISBN: 9783319632452
9783319632445
Physical Description: 1 online resource (xxi, 422 pages) : illustrations (some color)

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245 0 0 |a Pulmonary vasculature redox signaling in health and disease /  |c Yong-Xiao Wang, editor. 
264 1 |a Cham, Switzerland :  |b Springer,  |c 2017. 
300 |a 1 online resource (xxi, 422 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Advances in experimental medicine and biology,  |x 0065-2598 ;  |v volume 967 
500 |a Includes index. 
505 0 |a Preface -- About the Editor -- Contents -- Contributors -- Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension -- 1 Pulmonary Arterial Hypertension -- 2 Reactive Oxygen Species, NADPH Oxidase and PAH -- 3 Nox4 Expression in PAH -- 4 Enzymatic Properties of Nox4 -- 5 Role of the Adventitial Fibroblast and Nox4 in PAH -- References -- Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension -- 1 Introduction 
505 8 |a 2 Roles of Transcription Factors in Lung Diseases2.1 NF-ÎðB -- 2.2 AP-1 -- 2.3 STAT -- 2.4 TCF7 -- 2.5 NRF2 -- 2.6 HIF-1 -- 3 Redox-Sensitive Signaling in SMC Regulation: Role of TFs -- 4 Conclusion and Future Perspective -- References -- Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension -- 1 Introduction -- 2 Molecular Mechanisms of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension -- 3 Molecular Sources of Reactive Nitrogen Species in Pulmonary Hypertension 
505 8 |a 4 Molecular Sources of Reactive Oxygen Species in Pulmonary Hypertension5 Nitrative Stress in Pulmonary Hypertension Patients -- 6 Conclusions -- References -- Pentose Shunt, Glucose-6-ÂƯPhosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension -- 1 Pulmonary Hypertension -- 2 Warburg Effect and Pulmonary Hypertension -- 3 Glucose Metabolism, Pentose Shunt, and Glucose-ÂƯ6-ÂƯPhosphate Dehydrogenase in Pulmonary Hypertension -- 3.1 Glucose Metabolism is Altered in Pulmonary Hypertension 
505 8 |a 3.2 Glucose-6-Phosphate Dehydrogenase Inhibition Relaxes Pulmonary Arteries, Reduces Inflammatory Cytokines and Cell Proliferation, and Induces Cell Apoptosis3.3 Glucose-6-Phosphate Dehydrogenase Inhibitor Treatment Reduces Pulmonary Hypertension -- 4 G6PD and CD133 (+) Cells in Pulmonary Hypertension -- 4.1 CD133 (+) Cells -- 4.2 Glucose Metabolism and G6PD in CD133 (+) Cells -- 4.3 CD133 (+) Cells Increase in Pulmonary Hypertension -- 4.4 CD133 (+) Cells Exacerbate Pulmonary Arterial Hypertension -- References 
505 8 |a Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation1 Introduction -- 2 The Extracellular SOD3 Enzyme -- 2.1 Characterization of SOD3 -- 2.2 Redox Regulation of SOD3 -- 2.2.1 Intrasubunit Disulfide Bonds -- 2.2.2 Intersubunit Disulfide Bond -- 2.2.3 Proteolytic Cleavage of SOD3 -- 2.3 Regulation of SOD3 Activity -- 2.4 Regulation of SOD3 Gene Expression -- 2.5 Redox Regulation by SOD3 in Pulmonary Hypertension -- 3 The Mitochondrial SOD2 Enzyme -- 3.1 Characterization of SOD2 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others. 
504 |a Includes bibliographical references and index. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Active oxygen  |x Physiological effect. 
650 0 |a Oxidation, Physiological. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Wang, Yong-Xiao,  |e editor. 
776 0 8 |i Print version:  |t Pulmonary vasculature redox signaling in health and disease.  |d Cham, Switzerland : Springer, 2017  |z 9783319632445  |z 3319632442  |w (OCoLC)992747273 
830 0 |a Advances in experimental medicine and biology ;  |v v. 967. 
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993 |x NEPOSILAT  |y EIZ 

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