Particulate technology for delivery of therapeutics

The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose r...

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Bibliographic Details
Other Authors Jana, Sougata, Jana, Subrata
Format Electronic eBook
LanguageEnglish
Published Singapore : Springer, 2017.
Subjects
Nanoparticles.
elektronické knihy
electronic books
Online AccessFull text
ISBN9789811036477
9789811036460
Physical Description1 online resource

Cover

Table of Contents:
  • Preface
  • Contents
  • About the Editors
  • List of Contributors
  • 1 Introduction to Novel Therapeutic Carriers
  • Abstract
  • 1 Introduction
  • 2 Type of New Drug Carriers Systems
  • 2.1 Transdermal Drug Delivery System
  • 2.2 Carrier-Based Delivery Systems
  • 2.3 Variable Release Delivery Systems
  • 2.3.1 Osmotic Pump-Based Drug Delivery Systems
  • 2.3.2 Reservoir-Based System
  • 2.3.3 Matrix-Based Drug Delivery System
  • 3 Preparation of Particulate Drug Delivery Systems
  • 3.1 Dispersion Method
  • 3.2 Solvent Evaporation Method
  • 3.3 Emulsification or Solvent Diffusion Method3.4 Coacervation Method
  • 3.5 Polymerization Method
  • 3.6 Spray Drying and Congealing
  • 3.7 Emulsification-Cross-Linking Method
  • 3.8 Reverse Micellar Method
  • 3.9 Supercritical Method
  • 4 Release Kinetics from Nondegradable Polymeric Matrices
  • 5 Release Kinetics from Biodegradable Polymeric Matrices
  • 6 Concluding Remarks
  • References
  • 2 The Development and Achievement of Polymeric Nanoparticles for Cancer Drug Treatment
  • Abstract
  • 1 Introduction
  • 1.1 Physiological Conditions of Tumor Tissues
  • 1.2 Rationale of Cancer Nanotechnology1.3 Important Considerations in Nanoparticle-Based Delivery for Cancer Treatment
  • 1.3.1 Passive Targeting of Nanoparticles: Enhanced Permeability and Retention (EPR) Effect
  • 1.3.2 Active Targeting of Nanoparticles
  • 2 Polymeric Nanocarriers for Therapeutic Applications in Cancer
  • 2.1 Polymeric Micelles for Therapeutic Applications in Cancer
  • 2.1.1 Doxorubicin (DOX) Conjugated Polymeric Micelles
  • 2.1.2 Paclitaxel (PTX) Conjugated Polymeric Micelles
  • 2.1.3 Other Chemotherapeutic Drugs Conjugated Polymeric Micelles
  • 2.2 Polymeric Nanoparticles for Therapeutic Applications in Cancer2.2.1 PTX-Loaded Polymericnano Particles
  • 2.2.2 DOX-Loaded Polymeric Nanoparticles
  • 2.2.3 Other Chemotherapeutic Drugs Loaded Polymericnano Particles
  • 3 Stimuli-responsive Polymeric Nanocarriers
  • 3.1 Endogenous Stimuli-responsive Polymeric Nanoparticles and Micelles
  • 3.2 Exogenous Stimuli-Responsive Polymeric Nanoparticles and Micelles
  • 3.3 Multiple Stimuli-Responsive Polymeric Nanoparticles and Micelles
  • 4 Conclusions
  • Acknowledgements
  • References
  • 3 Nanotechnology-Based Immunotherapeutic Strategies for the Treatment of CancerAbstract
  • 1 Introduction
  • 2 Immunotherapies
  • 3 Cancer and Immune System
  • 3.1 Limitations of Existing Cancer Therapies
  • 4 Basics and Strategies of Cancer Immunotherapy
  • 4.1 Monoclonal Antibodies (mAbs)
  • 4.2 Cancer Vaccines
  • 4.3 Peptide Vaccines
  • 4.4 Tumor Cell Based Vaccines
  • 4.5 DNA Vaccines
  • 4.6 Vector-Based Vaccines
  • 4.7 Dendritic Cell Based Immunotherapy
  • 4.8 Immune Checkpoint Inhibitors
  • 4.9 Nonspecific Immunotherapies
  • 4.9.1 Nano-immunotherapy

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