Sigma proteins : evolution of the concept of sigma receptors

"Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is hi...

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Bibliographic Details
Other Authors Kim, Felix J. (Editor), Pasternak, Gavril W. (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, [2017]
SeriesHandbook of experimental pharmacology ; v. 244.
Subjects
Sigma receptors.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319658537
9783319658513
ISSN1865-0325 ;
Physical Description1 online resource (viii, 330 pages) : illustrations (chiefly color)

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Table of Contents:
  • Introduction to sigma proteins: evolution of the concept of sigma receptors / Felix J. Kim
  • Structural insights into sigma1 function / Andrew Kruse
  • 3d homology model of sigma1 receptor / Erik Laurini, Domenico Marson, Maurizio Fermeglia, Sabrina Pricl
  • Medicinal chemistry of [sigma]1 receptor ligands: pharmacophore models, synthesis, structure affinity relationships, and pharmacological applications / Frauke Weber, Bernhard Wünsch
  • Sigma-1 ([sigma]1) receptor in memory and neurodegenerative diseases / Tangui Maurice, Nino Goguadze
  • Sigma-1 receptor and neuronal excitability / Saïd Kourrich
  • Sigma-1 receptor and pain / Manuel Merlos, Luz Romero, Daniel Zamanillo, Carlos Plata-Salamán, José Miguel Vela
  • Allosteric modulation of opioid g-protein coupled receptors by sigma1 receptors / Gavril W. Pasternak
  • A role for sigma receptors in stimulant self-administration and addiction / Jonathan L. Katz, Takato Hiranita, Weimin C. Hong, Martin O. Job, Christopher R. McCurdy
  • Sigma receptors and alcohol use disorders / Valentina Sabino, Pietro Cottone
  • Sigma1 pharmacology in the context of cancer / Felix J. Kim, Christina M. Maher
  • Molecular probes for imaging the sigma-2 receptor: in vitro and in vivo imaging studies / Chenbo Zeng, Elizabeth S. McDonald, Robert H. Mach.

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