Photoaffinity labeling for structural probing within protein

• Other Authors: Hatanaka, Yasumaru, Hashimoto, Makoto
• Format: Electronic eBook
• Language: English
• Published: Tokyo : Springer, 2017.
• Subjects: Photoaffinity labeling.; Proteins > Structure.; elektronické knihy; electronic books
• ISBN: 9784431565697; 9784431565635; 9784431565680
• Physical Description: 1 online resource

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labe...

Table of Contents:

• Preface
• Chapter 1 Multifunctional Photoprobes for Identification of Ligand Sites within Biomolecules
• Chapter 2 Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains
• Chapter 3 Recent Developments in Designing Compact Biological Photoprobes
• Chapter 4 Utilities of Anti-Ligand Antibody and Mass Spectrum to Elucidate Photolabelled Sites
• Chapter 5 Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins
• Chapter 6 Synthesis of diazirinyl photophore and optically pure diazirinylphenylalanines for photoaffinity labeling
• Chapter 7 Photoreactive biomacromolecules: preparation using photoreactive units and applications for analyzing biological interfaces
• Chapter 8 Covalently capturing protein interactions in living cells by site-specific incorporation of photo-cross-linkable amino acids
• Chapter 9 Use of hexose photolabels to reveal the structure and function of glucose transporters
• Chapter 10 The function of the mammalian peroxisome and analysis of the fatty acid oxidation system by photoaffinity labeling
• Chapter 11 Photoaffinity labeling methods to explore internalization mechanisms of arginine-rich cell-penetrating peptides
• Chapter 12 Photoaffinity Labeling in Drug Discovery Research.