Genome editing in neurosciences

This book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technolog...

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Bibliographic Details
Other Authors Jaenisch, Rudolf (Editor), Zhang, Feng, 1982- (Editor), Gage, F. 1950- (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, 2017.
SeriesResearch and perspectives in neurosciences,
Subjects
Neurogenetics.
Genetic engineering.
RNA editing.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319601922
9783319601915
9783319649757
9783319649764
ISSN0945-6082
Physical Description1 online resource (xi, 123 pages) : color illustrations

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Table of Contents:
  • Introduction
  • In vitro modeling of complex neurological diseases
  • Aquatic model organisms in neurosciences : the genome editing revolution
  • Genome-wide genetic screening in the mammalian CNS
  • CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish
  • Dissecting the role of synaptic proteins with CRISPR
  • Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer
  • Neuroscience research using non-human primate models and genome editing
  • Multiscale genome engineering: Genome-wide screens and targeted approaches
  • Using Genome Engineering to Understand Huntington's Disease
  • Therapeutic gene editing in muscles and muscle stem cells.

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