Proteases in physiology and pathology

• Other Authors: Chakraborti, Sajal, Dhalla, Naranjan S.
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer, 2017.
• Subjects: Proteolytic enzymes.; elektronické knihy; electronic books
• ISBN: 9789811025136; 9789811025129
• Physical Description: 1 online resource

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors....

Table of Contents:

• Dedication; Preface; Contents; About the Editors; Part I: Regulation of Proteases in Health and Disease; 1: Physiological and Pathological Functions of Mitochondrial Proteases; 1.1 Introduction; 1.2 Physiological Roles of Mitoproteases; 1.2.1 Proteolysis in the Outer Membrane; 1.2.2 Proteolysis in the Intermembrane Space; 1.2.3 Proteolysis in the Inner Membrane; 1.2.4 Proteolysis in the Mitochondrial Matrix; 1.3 Pathological Contributions of Mitoproteases; 1.3.1 Mitochondrial Proteases in Cancer; 1.3.2 Mitochondrial Proteases in Neurodegenerative Diseases.
• 1.3.3 Mitochondrial Proteases in Multisystemic Diseases1.4 Conclusions; References; 2: The Role of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Embryonic Neural Crest Cells and Their Derivatives; 2.1 Introduction; 2.2 Matrix Metalloproteinases; 2.3 MMP-2 and MMP-9 in the Onset of NCC Migration; 2.4 MMP-2 and MMP-9 in NCC Derivatives in Embryos and Adults; 2.4.1 Cranial Cartilage and Bone; 2.4.2 Heart; 2.4.3 Melanocytes; 2.4.4 Adipocytes; 2.4.5 Enteric Neurons; 2.4.6 Glial Cells; 2.5 Activators and Repressors of MMP-2 and MMP-9 in NCCs; 2.6 Conclusion; References.
• 3: The Matrix Metalloproteinase and Tissue Inhibitors of Metalloproteinase Balance in Physiological and Pathological Remodeling of Skeletal Muscles3.1 Introduction; 3.2 MMPs and TIMPs in Skeletal Muscles: Expression and Role; 3.2.1 MMPs /TIMPs in Skeletal Muscle Cells; 3.2.1.1 Role of MMPs in Myogenic Cells; MMPs Contribute to Cell Migration; MMPs Contribute to Cell Fusion; 3.3 MMPs in Remodeling Skeletal Muscles; 3.3.1 Skeletal Muscle Plasticity; 3.3.2 Skeletal Muscle Degeneration and Regeneration; 3.4 Deregulation of MMPs in Skeletal Muscle Diseases; 3.4.1 Inflammatory Myopathies.
• 3.4.2 Muscular Dystrophies3.4.3 Neurogenic Myopathies; 3.5 MMPs/TIMPs Are Involved in Inflammation and Fibrosis of Diseased Skeletal Muscles; 3.5.1 MMP Involvement in Skeletal Muscle Inflammation; 3.5.2 MMP/TIMP Involvement in Skeletal Muscle Fibrosis; 3.6 Conclusion and Perspectives; References; 4: Role of BMP1/Tolloid like Proteases in Bone Morphogenesis and Tissue Remodeling; 4.1 Introduction; 4.2 Structure of the Protease Domain of BTPs; 4.2.1 Primary Structure; 4.2.2 X-ray Structure; 4.3 Substrate Specificity; 4.4 Biological Roles of BTPs; 4.4.1 Matrix Assembly.
• 4.4.2 Activation of Signalling Molecules4.5 BTP's and Disease; 4.5.1 Fibrosis; 4.5.2 Bone Disorders; 4.5.3 Cancer; 4.6 Modulators of BTPs; 4.6.1 Activators; 4.6.2 Inhibitors; 4.7 Conclusion and Future Perspectives; References; 5: Role of Proteases in the Regulation of N-Myristoyltransferase; 5.1 Introduction; 5.2 Differential Regulation of N-Myristoyltransferase Isoforms; 5.3 Regulation of NMT Functions by Proteases; 5.4 Summary; References; 6: Role of Tissue Factor-FVIIa Blood Coagulation Initiation Complex in Cancer; 6.1 Introduction.