Introduction to biomolecular structure and biophysics : basics of biophysics

This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon wit...

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Bibliographic Details
Other Authors: Misra, Gauri.
Format: eBook
Language: English
Published: Singapore : Springer, 2017.
Subjects:
Biophysics.
elektronické knihy
electronic books
ISBN: 9789811049682
9789811049699
9789811352799
9789811049675
Physical Description: 1 online resource

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Table of contents

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245 0 0 |a Introduction to biomolecular structure and biophysics :  |b basics of biophysics /  |c Gauri Misra, editor. 
260 |a Singapore :  |b Springer,  |c 2017. 
300 |a 1 online resource 
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505 0 |a Dedication; Foreword by Prof. Joel L. Sussman; Foreword by Shekhar C. Mande; Preface; Organization of the Book; Acknowledgments; Contents; About the Editor; 1: Principles of Protein Structure and Function; 1.1 Structure, Classification, and Properties of Amino Acids; 1.2 Structural Levels of Proteins; 1.2.1 Primary Structure; 1.2.2 Secondary Structure; 1.2.3 Tertiary Structure; 1.2.4 Quaternary Structure; 1.2.5 Forces Stabilizing Protein Structures; 1.3 Conformation of Globular Proteins; 1.3.1 Hemoglobin; 1.3.2 Myoglobin; 1.3.3 Lysozyme (1,4-beta-N-Acetylmuramidase); 1.3.4 Cytochromes. 
505 8 |a 1.4 Membrane Proteins1.4.1 Integral Proteins; 1.4.2 Peripheral Proteins; References; 2: Protein Folding; 2.1 Introduction; 2.2 Driving Forces in Protein Folding; 2.2.1 Electrostatic Interactions and Hydrogen Bond; 2.2.2 Hydrophobic Bonds; 2.2.3 Van der Waals Forces; 2.2.4 Disulfide Bonds; 2.2.5 Chaperones; 2.3 Protein Folding Mechanism; 2.3.1 Protein Folding Pathways; 2.3.1.1 Secondary and Tertiary Structure Formation; 2.3.1.2 Role of Water in Protein Folding; 2.3.2 Folding/Unfolding M-Values; 2.3.3 Models of Protein Folding; 2.3.4 Protein Misfolding; 2.4 Protein Structure and Stability. 
505 8 |a 2.4.1 Effect of Charged Ions and Chemical Reagents2.4.2 Effect of pH and Temperature; 2.4.3 Thermodynamic Linkage Between Protein Structure Stability and Function; 2.5 Conclusions; References; 3: Nucleic Acid Structure and Function; 3.1 Components of Nucleic Acids; 3.1.1 Nucleosides and Nucleotides; 3.1.2 Purine and Pyrimidine Bases; 3.1.3 Pentose and Phosphate; 3.2 Structure of Nucleic Acids; 3.2.1 Double-Helical Structure of DNA; 3.2.2 Helix Parameters; 3.2.3 DNA Supercoiling and Gyrase; 3.2.4 Intercalation; 3.2.5 Structure of RNA; 3.3 Different Forms of DNA; 3.3.1 A-DNA; 3.3.2 B-DNA. 
505 8 |a 3.3.3 Z-DNA3.3.4 Circular DNA; 3.4 Different Forms of RNA; 3.4.1 tRNA; 3.4.2 mRNA; 3.4.3 rRNA; 3.5 Structural and Biological Significance of Major and Minor Groove of DNA; 3.6 Chargaffś Rule; 3.7 Nucleic Acid Geometrics/Forces Stabilizing Nucleic Acid Structures; 3.7.1 Glycosidic Bond, Rotational Isomers, and Sugar Puckering; 3.7.2 Base Pairing; 3.7.3 Base Stacking; 3.8 Wobble Base-Pairing and Its Correlation with Genetic Diseases; 3.8.1 Introduction; 3.8.2 Wobble Hypothesis; 3.8.3 tRNA Base-Pairing Schemes; 3.8.4 Biological Importance. 
505 8 |a 3.8.5 Correlation Between the Wobble Base Pairing with Genetic Disease3.9 Properties of Nucleic Acids; 3.9.1 DNA Polymorphism; 3.9.2 Hyperchromicity; 3.9.3 Cot Curve; 3.9.4 C-Value Paradox; 3.10 Other Functions of Nucleotides; 3.10.1 Energy Carriers; 3.10.2 Chemical Messengers; 3.10.3 Enzyme Cofactor Components; 3.11 Nucleic Acid Fractionation; 3.11.1 Precipitation; 3.11.2 Electrophoresis; 3.11.3 Chromatography; 3.11.4 Ultracentrifugation; 3.11.5 Solid Phase Extraction/Chaotropic Agents; References; 4: Higher-Order Nucleic Acid Structures; 4.1 Tertiary Structure of Nucleic Acid. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small Angle X-ray Scattering (SAXS) and cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques used to study important biomolecules. 
504 |a Includes bibliographical references. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Biophysics. 
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655 9 |a electronic books  |2 eczenas 
700 1 |a Misra, Gauri. 
776 0 8 |i Print version:  |t Introduction to biomolecular structure and biophysics.  |d Singapore : Springer, 2017  |z 9789811049675  |z 981104967X  |w (OCoLC)985082398 
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