Neurotoxicity of metals
In this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders hav...
Saved in:
| Other Authors | , |
|---|---|
| Format | Electronic eBook |
| Language | English |
| Published |
Cham :
Springer,
2017.
|
| Series | Advances in neurobiology ;
18. |
| Subjects | |
| Online Access | Full text |
| ISBN | 9783319601892 9783319601885 |
| Physical Description | 1 online resource |
Cover
Table of Contents:
- Part I: Developmental Neurotoxicity; Developmental Neurotoxicity of Lead; Introduction; Developmental Exposures to Lead; Neurobehavioral Effects of Lead; Molecular Mechanisms of Neurotoxicity; Developmental Exposures to Lead and Alzheimer's Disease; Conclusions; References; Manganese and Developmental Neurotoxicity; Manganese in the Environment; Airborne Particles; Deposited Dust; Surface Soil; Edible Vegetables; Drinking Water; Toxicology and Biomarkers; Metabolism; Pediatric Absorption; Biomarkers; Effects on Cognitive Functions; Intellectual Ability.
- Executive Function Memory; Academic Achievement; Effects on Motor Functions; Behavior; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder; Other Behavioral Outcomes; Effects on Olfactory Function; References; Inherited Disorders of Manganese Metabolism; Introduction; SLC30A10; SLC39A14; SLC39A8; Concluding Perspectives; References; Part II: Neurodegenerative Disorders; Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity; Introduction; Selenium in the Environment and in the Living Organisms; Selenium: Neurotoxic or Neuroprotector?
- From Selenide to Selenoproteins Selenoproteins in the Brain; Mercury in the Environment and in the Living Organisms; Inorganic Mercury Neurotoxicity; Organic Mercury Neurotoxicity; Selenium and Mercury: Brain Antagonistic Interactions; Selenium as Antagonist of Inorganic Mercury Neurotoxicity; Selenium as an Antagonist of the Neurotoxicity Induced by Organic Mercury; Conclusion; References; Metals and Paraoxonases; Introduction; PON1; Human Polymorphisms of PON1 and Definition of PON1 Status; Modulation of PON1 Activity and Expression; PON2.
- PON2 as an Intracellular Antioxidant Enzyme Modulation of PON2; PON3: Activity, Polymorphisms, Physiological Functions, and Modulation; Interactions of Metals with PONs; In Vitro Effects of Metals on PONs; Effects of Metals on PONs: Animal Studies; Metals and PONs: Human Studies; Lead; Arsenic; Methylmercury and Selenium; Cadmium; Other Metals; Potential Mechanisms of PON1 Modulation by Metals; Summary and Conclusions; References; Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders; Introduction.
- IIS Signaling and Its Role in the Brain Mn and Insulin/IGF Homeostasis; HD Pathobiology; Mn Dysregulation in HD; IIS Dysregulation in HD; Autophagy Deficits in HD, Potential Links to Mn and IIS; Mitochondrial Pathology in HD, Possible Links to Mn and IIS; IIS Signaling and Mn in Other NDDs; PD and IIS/Mn; AD and IIS/Mn; ALS and IIS/Mn; Autophagy in Other Neurodegenerative Diseases; Manganese Toxicity and IGF; The Co-regulation of ATM, Mn, and Insulin/IGF; IIS Signaling, Mn, and Cancer; Conclusions; References; Occupational Metal Exposure and Parkinsonism; Introduction.