Centromeres and kinetochores : discovering the molecular mechanisms underlying chromosome inheritance

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms contro...

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Bibliographic Details
Other Authors: Black, Ben E.
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, [2017]
Series: Progress in molecular and subcellular biology ; 56.
Subjects:
Centromere.
Chromosomes.
Proteins.
Cellular control mechanisms.
elektronické knihy
electronic books
ISBN: 9783319585925
9783319585918
Physical Description: 1 online resource : illustrations

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024 7 |a 10.1007/978-3-319-58592-5  |2 doi 
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245 0 0 |a Centromeres and kinetochores :  |b discovering the molecular mechanisms underlying chromosome inheritance /  |c Ben E. Black, editor. 
264 1 |a Cham, Switzerland :  |b Springer,  |c [2017] 
300 |a 1 online resource :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Progress in molecular and subcellular biology,  |x 0079-6484 ;  |v v. 56 
504 |a Includes bibliographical references. 
505 0 |a Preface; Contents; Identification, Organization, and Regulation of Centromere and Kinetochore Components; 1 Use of Mass Spectrometry to Study the Centromere and Kinetochore; Abstract; 1 Discovery of Centromere Proteins Using Anti-centromere Autoantibodies; 2 Identification of Centromere Proteins Using Yeast Genetic Screens; 3 Post-genomics Approaches to Discover Centromere Proteins: RNAi Screening in C. elegans; 4 Identification of Centromere/Kinetochore Proteins by Affinity-Purification Mass Spectrometry (AP-MS); 5 Shotgun Proteomics of Isolated Yeast Kinetochores. 
505 8 |a 6 Shotgun Proteomics of Whole Isolated Mitotic Chromosomes7 Use of Mass Spectrometry to Study Kinetochore Protein Complexes; 8 Use of CLMS Mass Spectrometry to Study the Ultra-structure of Kinetochore Protein Complexes; 9 Future Prospects; Acknowledgements; References; 2 Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN); Abstract; 1 Introduction; 2 Centromere; 2.1 Centromere Organization; 2.2 CENP-A Is a Critical Epigenetic Mark for Centromere Specification; 3 CCAN Organization; 3.1 CCAN Subcomplexes; 3.1.1 CENP-C; 3.1.2 CENP-H/I/K/M; 3.1.3 CENP-L/N. 
505 8 |a 3.1.4 CENP-O/P/Q/R/U3.1.5 CENP-T/S/W/X; 3.2 CCAN Organization and Functions; 3.2.1 CCAN Interaction; 3.2.2 The CCAN as a Bridge Between Centromere and Microtubule; 3.2.3 In Vitro Reconstitution of the CCAN; 3.2.4 The CCAN-Dependent Stabilization of Centromere Position; 4 Dynamic Rearrangement of CCAN Organization; 4.1 Reorganization of the CCAN During the Cell Cycle; 4.2 CCAN Organization During Development; 5 Conclusion; Acknowledgements; References; 3 The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function; Abstract; 1 Introduction. 
505 8 |a 2 Reconstituting Centromere and Kinetochore Functions In Vitro2.1 Xenopus Egg Extract as a Versatile System for In Vitro Reconstitution; 3 Application of Frog Egg Extracts to Study Centromere and Kinetochore Function; 3.1 Epigenetic Maintenance of Centromere Identity; 3.2 CCAN Assembly; 3.3 Kinetochore Assembly; 3.4 The Spindle Assembly Checkpoint; 4 Conclusion; References; 4 Centrochromatin of Fungi; Abstract; 1 Introduction; 2 Centromeric DNA Sequence: Many Ways to Shape a Remarkable Genetic Locus; 2.1 The Dark Matter of Fungal Centromeres Lies in the Basal Lineages. 
505 8 |a 2.2 Fission Yeast, Budding Yeast, and the Dimorphic Candida as Models for Centromere Research2.3 Filamentous Fungi Contain Diverse Types of Centromeres; 3 Centrochromatin; 4 Summary; References; 5 Evolutionary Lessons from Species with Unique Kinetochores; Abstract; 1 Introduction; 2 The Kinetochore Complex in Animals and Fungi; 2.1 Similarities and Variations of the Inner Kinetochore in Animals and Fungi; 2.2 The Composition of the Outer Kinetochore Is Highly Conserved in Animals and Fungi; 3 Glimpses into Kinetochore Compositions in Diverse Eukaryotes; 3.1 Supergroup Amoebozoa. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Centromere. 
650 0 |a Chromosomes. 
650 0 |a Proteins. 
650 0 |a Cellular control mechanisms. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Black, Ben E. 
776 0 8 |i Print version:  |z 9783319585918  |z 3319585916  |w (OCoLC)982651812 
830 0 |a Progress in molecular and subcellular biology ;  |v 56. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-58592-5  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97474  |d 97474 
993 |x NEPOSILAT  |y EIZ 

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