Hormones in ageing and longevity
This multi-chapter book focuses on one of the hottest topics in ageing research - the role of hormones in health and longevity, offering a comprehensive and up-to-date overview of their mechanistic roles in health, ageing and longevity. Hormones are an excellent system of communication between cells...
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| Other Authors | , |
|---|---|
| Format | Electronic eBook |
| Language | English |
| Published |
Cham :
Springer,
[2017]
|
| Series | Healthy ageing and longevity ;
v. 6. |
| Subjects | |
| Online Access | Full text |
| ISBN | 9783319630014 9783319630007 |
| Physical Description | 1 online resource |
Cover
Table of Contents:
- Preface; Contents; History and Conflux; 1 How Hormones, as Ancient Signalling Molecules, Regulate Diverse Biological Processes Through Evolution; Abstract; 1.1 Introduction; 1.2 Evolution: Hormones Are Messengers but Do not Carry Any Information; 1.3 Environmental Cues and Endocrine Cascades; 1.4 Receptors: Key to the Understanding of the Mechanism of Hormone Action; 1.5 Membrane Receptors; 1.6 Nuclear Receptors; 1.7 Chromatin Structure and Hormonal Regulation; 1.8 Integration of the Membrane- and Nuclear Receptor-Linked Hormonal Pathways; 1.9 Hormones and Their Actions Through Evolution.
- 3.2 Glucocorticoid Cascade Hypothesis3.2.1 Glucocorticoids in Health; 3.2.2 Glucocorticoids in Clinical Science; 3.2.3 Glucocorticoids Side Effects; 3.3 Glucocorticoids in Aging; 3.3.1 Glucocorticoids, HPA Axis and Aging; 3.3.2 Glucocorticoids Extra- and Intra-cellular Bioavailability with Age; 3.3.3 Glucocorticoids Genomic Signaling as a Function of Age; 3.3.4 Glucocorticoids Non-genomic Signaling in Aging; 3.4 Management of Glucocorticoids Induced Age-Related Complications via GR Signaling Pathway Modulation; 3.5 Conclusion; Acknowledgements; References.
- 4 Zinc, Insulin and IGF-I Interplay in AgingAbstract; 4.1 Introduction; 4.2 Biological Functions of Zn; 4.3 Zinc in Biogerontology; 4.3.1 Zn Supplements and Longevity; 4.3.2 Zn Regulatory Mechanisms and Longevity; 4.4 Zinc Insulin Interplay; 4.4.1 Zinc Action on Insulin Activity; 4.4.2 Influence of Zinc Machinery on Insulin Activity; 4.4.3 Insulin Action on Zn Homeostasis; 4.5 Zinc IGF-1 Interplay; 4.5.1 Modulation of IGF-1 Action by Zn Signals; 4.5.2 Modulation of Zn Homeostasis by IGF-1; 4.6 Conclusions; References; Supplementary Data; Human:; Mus Musculus.
- 5 Growth Hormone and IGF-1 Axis in Aging and LongevityAbstract; 5.1 Introduction; 5.2 Decline of the GH-IGF-1 Axis and Replacement Therapy in Elderly People; 5.3 Loss-of- or Reduction-of Function Mutations of Genes in the GH Signal Transduction Pathway Consistently Extend Lifespan in a Range of Experimental Animals; 5.4 Lifespan Extension by Single Gene Mutations Related to the Reduction of the GH-IGF-1 Axis; 5.5 Genes Downstream of IGF-1 Signaling that Lead to Lifespan Extension; 5.6 Evidence in Humans Indicating a Relation Between Longevity and Inhibition of the GH-IGF-1 Axis.