Long non coding RNA biology

• Other Authors: Rao, M. R. S. 1948- (Editor)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer, 2017.
• Series: Advances in experimental medicine and biology ; v. 1008.
• Subjects: Non-coding RNA.; elektronické knihy; electronic books
• ISBN: 9789811052033; 9789811052026
• Physical Description: 1 online resource (336 pages)

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fasci...

Table of Contents:

• Foreword; Preface; Contents; About the Editor; Chapter 1: History, Discovery, and Classification of lncRNAs; 1.1 A Hundred-Years History of RNA Biology; 1.1.1 From "Nuclein" to Nucleic Acids and to the Double Helix; 1.1.2 A Central Role for RNA in Cell Biology: The RNA World Concept; 1.1.3 Bacterial sRNAs: Pioneers of Regulatory ncRNAs; 1.1.4 MicroRNAs and RNA Interference; 1.2 LncRNA Discovery in the Pre-genomic Era; 1.2.1 H19: The Very First Eukaryote lncRNA Gene; 1.2.2 X Inactivation: Existence of Xist; 1.3 From Non-coding Genome to Non-coding Transcriptome: The Genomic Era.
• 1.3.1 The Human Genome Project: Genomic DNA Is Mostly Non-coding1.3.2 Pervasive Transcription and the Dark Matter of the Genome; 1.4 Non-coding RNAs: Junk or Functional; 1.4.1 Origin of lncRNA Genes; 1.4.2 Evolutionary Conservation of lncRNAs; 1.4.3 Role of lncRNAs in Biological Diversity; 1.5 The General Portrait of lncRNA Genes and Transcripts; 1.5.1 Coding Potential of lncRNA Genes; 1.5.2 LncRNA Transcription and Transcript Organization; 1.5.3 Chromatin Signatures of lncRNAs Genes; 1.5.4 Expression Pattern of lncRNAs: Stability, Specificity, and Abundance.
• 1.5.5 Subcellular Localization of lncRNAs1.5.6 Structure of lncRNAs; 1.6 Classification of lncRNAs; 1.6.1 Classification According to lncRNA Length; 1.6.2 Classification According to lncRNA Location with Respect to PCGs; 1.6.3 Classification According to lncRNA Residence Within Specific DNA Regulatory Elements and Loci; 1.6.4 Classification According to lncRNA Biogenesis Pathways; 1.6.5 Classification According to lncRNA Subcellular Localization or Origin; 1.6.6 Classification According to lncRNA Function; 1.6.7 Classification According to lncRNA Association with Specific Biological Processes.
• 1.6.8 Future Challenges in lncRNA Annotation and ClassificationReferences; Chapter 2: Long Noncoding RNA: Genome Organization and Mechanism of Action; 2.1 Introduction; 2.2 lncRNA and Chromatin Regulation; 2.3 lncRNAs Regulate Chromatin Structure via Histone Modifications; 2.4 lncRNAs Regulate Chromatin Remodeling; 2.5 eRNAs and Higher-Order Chromatin Organization; 2.6 Long Noncoding RNAs in Genomic Imprinting; 2.7 Posttranscriptional Regulation by lncRNAs; 2.8 lncRNAs in Staufen-Mediated mRNA Decay; 2.9 Biology of Natural Antisense Transcripts.
• 2.10 lncRNA-Mediated Regulation of Protein Activity2.11 Nuclear Architecture and Long Noncoding RNAs; 2.12 lncRNAs and Nucleolar Function; 2.13 lncRNAs Are Critical Components of Paraspeckles; 2.14 lncRNAs in Nuclear Speckles and Polycomb Bodies; 2.15 lncRNA and Topological Organization of Multichromosomal Regions; 2.16 lncRNAs and Centromere Function; 2.17 Conclusion and Outlook; References; Chapter 3: From Heterochromatin to Long Noncoding RNAs in Drosophila: Expanding the Arena of Gene Function and Regulation; 3.1 Introduction.