Biomedical Applications of Acridines : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases.
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, i...
Saved in:
| Main Author | |
|---|---|
| Other Authors | , |
| Format | Electronic eBook |
| Language | English |
| Published |
Cham :
Springer International Publishing,
2017.
|
| Series | Progress in drug research ;
v. 72. |
| Subjects | |
| Online Access | Full text |
| ISBN | 9783319639536 9783319639543 9783319876801 9783319639529 |
| Physical Description | 1 online resource (243 pages) |
Cover
| LEADER | 00000cam a2200000Mi 4500 | ||
|---|---|---|---|
| 001 | 97464 | ||
| 003 | CZ-ZlUTB | ||
| 005 | 20251008101056.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 170819s2017 xx ob 001 0 eng d | ||
| 040 | |a EBLCP |b eng |e pn |c EBLCP |d N$T |d YDX |d GW5XE |d OCLCF |d UAB |d AZU |d UPM |d MERER |d OCLCQ |d ESU |d IOG |d COO |d OCLCQ |d JG0 |d U3W |d CAUOI |d KSU |d VT2 |d WYU |d OCLCQ |d UKAHL |d OCLCQ |d AUD |d ADU |d LEATE |d OCLCQ | ||
| 020 | |a 9783319639536 |q (electronic bk.) | ||
| 020 | |a 9783319639543 |q (print) | ||
| 020 | |a 9783319876801 |q (print) | ||
| 020 | |z 9783319639529 | ||
| 024 | 7 | |a 10.1007/978-3-319-63953-6 |2 doi | |
| 035 | |a (OCoLC)1001368938 |z (OCoLC)1001541513 |z (OCoLC)1004543174 |z (OCoLC)1005012266 |z (OCoLC)1011908072 |z (OCoLC)1048206000 |z (OCoLC)1049849369 |z (OCoLC)1066573700 |z (OCoLC)1111182100 |z (OCoLC)1112842131 |z (OCoLC)1116997965 |z (OCoLC)1122817767 |z (OCoLC)1160043571 | ||
| 100 | 1 | |a Ježek, Jan. | |
| 245 | 1 | 0 | |a Biomedical Applications of Acridines : |b Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases. |
| 260 | |a Cham : |b Springer International Publishing, |c 2017. | ||
| 300 | |a 1 online resource (243 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a počítač |b c |2 rdamedia | ||
| 338 | |a online zdroj |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in Drug Research ; |v v. 72 | |
| 505 | 0 | |a Acknowledgements; Contents; Acronyms; 1 Introduction; References; 2 Nomenclature; References; 3 Syntheses; 3.1 Syntheses of Acridine Ring and Its Precursors; 3.2 Acridine-Peptide Conjugates; 3.3 Acridines as Catalysts; References; 4 Interactions of Acridines with Nucleic Acids; 4.1 DNA; 4.2 DNA Quadruplexes; 4.3 RNA; 4.4 PNA; 4.5 Acridine Metal Complexes; 4.6 Structural Aspects of Nucleic Acid Binding; References; 5 Interactions with Proteins; 5.1 Interactions with Nucleic Acids Processing Proteins; 5.1.1 Topoisomerases; 5.1.2 Transcription Factors; 5.1.3 RecA Protein; 5.1.4 Telomerase. | |
| 505 | 8 | |a 5.2 Interactions with Other Proteins5.3 Structural Aspects of Acridine Interactions with Proteins; References; 6 Applications for Treatment of Neurodegenerative Diseases; 6.1 Alzheimer's Disease; 6.1.1 Multitargeted Strategy in AD; 6.2 Parkinson's Disease; 6.3 Prion Diseases; 6.4 Other Neurodegenerative Diseases; References; 7 Some Application of Selective Toxicities of Acridines; 7.1 Antiparasitic Drug; 7.2 Cancer Treatment; 7.3 Antibacterial Drugs; 7.4 Antiviral Drugs; References; 8 Pharmacokinetics and Metabolism of Acridine Drugs; References; 9 Acridine on Dendrimeric Carriers. | |
| 505 | 8 | |a 9.1 Application for Drug and Gene DeliveryReferences; 10 Acridines Used for Staining; References; 11 Miscellaneous; References; 12 Conclusions and Outlook; Index. | |
| 504 | |a Includes bibliographical references and index. | ||
| 506 | |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty | ||
| 520 | |a This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy. | ||
| 590 | |a SpringerLink |b Springer Complete eBooks | ||
| 650 | 0 | |a Acridine. | |
| 655 | 7 | |a elektronické knihy |7 fd186907 |2 czenas | |
| 655 | 9 | |a electronic books |2 eczenas | |
| 700 | 1 | |a Hlaváček, Jan. | |
| 700 | 1 | |a Šebestík, Jaroslav. | |
| 776 | 0 | 8 | |i Print version: |a Ježek, Jan. |t Biomedical Applications of Acridines : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases. |d Cham : Springer International Publishing, ©2017 |z 9783319639529 |
| 830 | 0 | |a Progress in drug research ; |v v. 72. | |
| 856 | 4 | 0 | |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-63953-6 |
| 992 | |c NTK-SpringerBLS | ||
| 999 | |c 97464 |d 97464 | ||
| 993 | |x NEPOSILAT |y EIZ | ||