Mechanisms of vascular defects in diabetes mellitus.

• Other Authors: Kartha, C. Chandrasekharan, Ramachandran, Surya, Pillai, Radhakrishna
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer, 2017.
• Series: Advances in biochemistry in health and disease ; v. 17.
• Subjects: Diabetic angiopathies.; elektronické knihy; electronic books
• ISBN: 9783319603247; 9783319603230
• Physical Description: 1 online resource

This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hypergly...

Table of Contents:

• Preface; Contents; Contributors; About the Editors; Part I: Introduction; Chapter 1: The Global Burden of Diabetes and Its Vascular Complications; 1.1 Introduction; 1.2 Global Burden of Diabetes; 1.3 Vascular Complications; 1.3.1 Microvascular Complications; 1.3.1.1 Diabetic Retinopathy (DR); 1.3.1.2 Diabetic Nephropathy; 1.3.1.3 Diabetic Neuropathy; 1.3.2 Macrovascular Complications; 1.3.2.1 Cardiovascular Disease; 1.3.2.2 Peripheral Vascular Disease; 1.3.2.3 Cerebrovascular Disease; 1.3.3 Overlap Between Micro and Macrovascular Complications.
• 1.4 Mortality Due to Diabetes Associated Complications; 1.5 Conclusions and the Way Forward; References; Part II: Pathogenesis; Chapter 2: Genetic Basis for Increased Risk for Vascular Diseases in Diabetes; 2.1 Introduction; 2.2 Clinical Presentations of Type 2 Diabetes; 2.3 Vascular Diseases; 2.3.1 Microvascular Diseases; 2.3.2 Macrovascular Diseases; 2.4 Pathophysiology of Diabetic Complications; 2.5 Risk Assessment in the Diabetic Patient; 2.6 Risk Factors for Development of Diabetic Vascular Complications; 2.6.1 Insulin Resistance; 2.6.2 Atherogenic Dyslipidemia; 2.6.3 Hypertension.
• 2.11.3 GWAS for Coronary Heart Diseases in Type 2 Diabetes; 2.11.3.1 Insights from GWAS for CHD; 2.12 Epigenetics and Diabetic Complications; 2.13 Conclusions; References; Chapter 3: Vascular Remodeling in Diabetes Mellitus; 3.1 Introduction; 3.2 Overview of Vascular Remodeling; 3.3 Mediators of DM Induce VRM; 3.3.1 Hyperglycemia and Related Metabolic Abnormalities; 3.3.1.1 Polyol and Hexosamine Pathway; 3.3.1.2 Diacyglycerol (DAG); 3.3.2 Advanced Glycation End Products (AGE); 3.3.2.1 Receptor Mediated Mechanisms; 3.3.2.2 Non-receptor Mediated Mechanisms; 3.3.3 Insulin Abnormalities.
• 3.3.4 Excess Free Fatty Acid Production; 3.3.5 Increased Angiotensin II and Endothelin-1; 3.3.6 DM Associated Hyperlipidemia and Hypertension; 3.3.7 Abnormal Shear Stress; 3.4 Pathophysiological Mechanisms of Diabetes Induced Vascular Remodeling; 3.4.1 Oxidative Stress and Endothelial Dysfunction; 3.4.2 Endoplasmic Reticulum Stress and Autophagy; 3.4.3 Inflammation; 3.4.4 Vascular Calcification; 3.4.4.1 Mechanisms of Vascular Calcification; 3.4.5 Genetic and Epigenetic Effects on Diabetic VRM; 3.5 Overview of Morphological Changes in DM Induced VRM; 3.5.1 Endothelial Cell Alterations.