Decoding neural circuit structure and function : cellular dissection using genetic model organisms
This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particular...
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| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer,
2017.
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| Subjects: | |
| ISBN: | 9783319573632 9783319573625 |
| Physical Description: | 1 online resource |
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Table of contents
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| 245 | 0 | 0 | |a Decoding neural circuit structure and function : |b cellular dissection using genetic model organisms / |c Arzu Çelik, Mathias F. Wernet, editors. |
| 260 | |a Cham : |b Springer, |c 2017. | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a počítač |b c |2 rdamedia | ||
| 338 | |a online zdroj |b cr |2 rdacarrier | ||
| 505 | 0 | |a Foreword; We Live in Exciting Times; Contents; Notes from the Editors; Anatomy: High-Resolution Neuroanatomy Using Molecular-Genetic Tools; 1 The Current State of the Neuroanatomy Toolkit in the Fruit Fly Drosophila melanogaster; Abstract; 1.1 Introduction; 1.2 Binary Activation Systems; 1.2.1 The GAL4 System; 1.2.2 The LexA System; 1.2.3 The Q System; 1.3 Neurogenetic Labeling; 1.3.1 Fluorescent Protein Reporters; 1.3.2 Non-fluorescent Protein Reporters; 1.4 Regulating Binary Activators; 1.4.1 Enhancer Trapping and Bashing; 1.4.2 Promoter Bashing and Trapping; 1.4.3 Protein Trapping. | |
| 505 | 8 | |a 1.5 Refining Genetic Targeting by Intersectional Perturbations1.5.1 OR Gates; 1.5.2 AND Gates; 1.5.3 NOT Gates; 1.5.4 Combinatorial AND/NOT Gating; 1.6 Mitotic Analysis and Multicolor Stochastic Labeling Strategies in D. melanogaster; 1.7 Conclusions and Future Directions; Acknowledgements; References; 2 Retinal Connectomics; Abstract; 2.1 Introduction; 2.2 Some Basic Retinal Anatomy; 2.3 Why Is Retinal Connectomics Difficult?; 2.4 The Long Overdue Automation of Electron Microscopy; 2.5 The Real Bottleneck-Data Analysis; 2.6 A Retinal 'Contactome' | |
| 505 | 8 | |a 2.7 Correlating Retinal Structure with Function2.8 Species-Dependent Differences in Retinal Wiring; 2.9 Future of Retinal Connectomics; References; 3 Recent Progress in the 3D Reconstruction of Drosophila Neural Circuits; Abstract; 3.1 Introduction; 3.1.1 The Fly CNS as a Model System of Connectomics Study; 3.1.2 Anatomy of the Drosophila CNS; 3.2 Reconstruction of Neuronal Circuits and Analysis Using CLSM Image Data; 3.2.1 Visualizing Neurons with Confocal Laser Microscopy; 3.2.2 Three-Dimensional Reconstruction of Neurons in the Fly Brain. | |
| 505 | 8 | |a 3.2.2.1 Algorithms for Three-Dimensional Reconstruction3.2.2.2 FluoRender: A Volume Rendering Tool Optimized for CLSM Volume Data; 3.2.3 3D Registration of Brains; 3.2.4 Application of 3D Reconstruction and Registration; 3.2.4.1 Clonal Unit Analysis; 3.2.4.2 Prediction of Synaptic Partners; 3.3 Electron Microscopy-Based Reconstruction and Connectomics; 3.3.1 Ultrastructures Visualized with EM; 3.3.2 Strategies of 3D Reconstruction; 3.3.2.1 Dense (Saturated) Reconstruction/Sparse Reconstruction; 3.3.2.2 Volumetric Reconstruction/Skeletonized Reconstruction. | |
| 505 | 8 | |a 3.3.2.3 Manual Tracing/Automatic Tracing3.3.3 3D EM Methods in Connectomics Studies of Drosophila CNS; 3.3.3.1 Serial-Section Transmission EM (ssTEM); 3.3.3.2 Serial Block-Face Scanning EM (SBF-SEM); 3.3.3.3 Focused-Ion Beam-Aided Scanning EM (FIB-SEM); 3.3.4 EM Connectomics Studies in the Fly CNS; 3.3.4.1 Connectivity Analysis in the Optic Lobe Neuropils Using ssTEM and FIB-SEM Methods; 3.3.4.2 Imaging the Blowfly Brain with SBF-SEM; 3.3.4.3 Reconstruction of the Larval CNS with ssTEM; 3.3.5 Other Imaging Techniques for Large-Scale Connectomics. | |
| 506 | |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty | ||
| 520 | |a This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types ("connectomics") using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior. | ||
| 504 | |a Includes bibliographical references. | ||
| 590 | |a SpringerLink |b Springer Complete eBooks | ||
| 650 | 0 | |a Neuroanatomy. | |
| 650 | 0 | |a Neural circuitry. | |
| 655 | 7 | |a elektronické knihy |7 fd186907 |2 czenas | |
| 655 | 9 | |a electronic books |2 eczenas | |
| 700 | 1 | |a Celik, Arzu. | |
| 700 | 1 | |a Wernet, Mathias F. | |
| 776 | 0 | 8 | |i Print version: |t Decoding neural circuit structure and function. |d Cham : Springer, 2017 |z 9783319573625 |z 3319573624 |w (OCoLC)981117475 |
| 856 | 4 | 0 | |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-57363-2 |y Plný text |
| 992 | |c NTK-SpringerBLS | ||
| 999 | |c 97436 |d 97436 | ||
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