Essential and non-essential metals : carcinogenesis, prevention and cancer therapeutics

This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, I...

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Bibliographic Details
Other Authors: Mudipalli, Anuradha, (Editor), Zelikoff, Judith T., (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Humana Press, 2017.
Series: Molecular and integrative toxicology.
Subjects:
Chemical carcinogenesis.
Metals > Physiological effect.
Metals > Therapeutic use.
elektronické knihy
electronic books
ISBN: 9783319554488
9783319554464
Physical Description: 1 online resource (xii, 228 pages) : illustrations (some color)

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020 |a 9783319554488  |q (electronic bk.) 
020 |z 9783319554464  |q (print) 
024 7 |a 10.1007/978-3-319-55448-8  |2 doi 
035 |a (OCoLC)994006138  |z (OCoLC)1002345992  |z (OCoLC)1005753372  |z (OCoLC)1011956486  |z (OCoLC)1097164784 
245 0 0 |a Essential and non-essential metals :  |b carcinogenesis, prevention and cancer therapeutics /  |c Anuradha Mudipalli, Judith T. Zelikoff, editors. 
264 1 |a Cham, Switzerland :  |b Humana Press,  |c 2017. 
300 |a 1 online resource (xii, 228 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Molecular and integrative toxicology,  |x 2168-4219 
500 |a Includes index. 
505 0 |a Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do. 
504 |a Includes bibliographical references at the end of each chapters and index. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Chemical carcinogenesis. 
650 0 |a Metals  |x Physiological effect. 
650 0 |a Metals  |x Therapeutic use. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Mudipalli, Anuradha,  |e editor. 
700 1 |a Zelikoff, Judith T.,  |e editor. 
776 0 8 |i Printed edition:  |z 9783319554464 
830 0 |a Molecular and integrative toxicology. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-55448-8  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97425  |d 97425 
993 |x NEPOSILAT  |y EIZ 

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