Heart failure

"This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imag...

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Bibliographic Details
Other Authors Bauersachs, Johann (Editor), Butler, Javed (Editor), Sandner, Peter (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, [2017]
SeriesHandbook of experimental pharmacology ; v. 243.
Subjects
Online AccessFull text
ISBN9783319596594
9783319596587
ISSN1865-0325 ;
Physical Description1 online resource (ix, 581 pages) : illustrations (some color)

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Table of Contents:
  • The three-decade long journey in heart failure drug development / Kelly S. Lewis, Javed Butler, Johann Bauersachs, Peter Sandner
  • Epidemiology of heart failure / Francesco Orso, Gianna Fabbri, Aldo Pietro Maggioni
  • Comorbidities in heart failure / Haye H. van der Wal, Vincent M. van Deursen, Peter van der Meer, Adriaan A. Voors
  • Clinical trial design, endpoints, and regulatory requirements / Giuseppe M.C. Rosano
  • Biomarkers of heart failure with preserved and reduced ejection fraction / Michele Senni, Emilia D'Elia, Michele Emdin, Giuseppe Vergaro
  • Heart failure guidelines on pharmacotherapy / Lampros Papadimitriou, Carine E. Hamo, Javed Butler
  • Sacubitril/valsartan (LCZ696) in heart failure / Yasser Khder, Victor Shi, John J.V. McMurray, Martin P. Lefkowitz
  • Ivabradine / Michel Komajda
  • Partial adenosine A1 agonist in heart failure / Wilfried Dinh, Barbara Albrecht-Küpper, Mihai Gheorghiade, Adriaan A. Voors [and others]
  • New and emerging therapies and targets: beta-3 agonists / Lauriane Y.M. Michel, Jean-Luc Balligand
  • Novel SGC stimulators and SGC activators for the treatment of heart failure / Stefanie Breitenstein, Lothar Roessig, Peter Sandner, Kelly S. Lewis
  • Cardiac phosphodiesterases and their modulation for treating heart disease / Grace E. Kim PhD, David A. Kass MD
  • Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: comparison at bench and bedside / Peter Kolkhof, Frederic Jaisser, So-Young Kim, Gerasimos Filippatos, Christina Nowack [and others]
  • Vasopressin and vasopressin antagonists in heart failure / Julie K. Vishram-Nielsen, Finn Gustafsson
  • Mesenchymal stem cell therapy for the treatment of heart failure caused by ischemic or non-ischemic cardiomyopathy: immunosuppression and its implications / Michael J. Lipinski, Dror Luger, Stephen E. Epstein
  • Platelet-derived growth factor in heart failure / John Medamana, Richard A. Clark, Javed Butler
  • Wnt signaling in cardiac remodeling and heart failure / Vasili Stylianidis, Kevin C.M. Hermans, W. Matthijs Blankesteijn
  • Gene therapy in heart failure / Anthony S. Fargnoli, Michael G. Katz, Charles R. Bridges, Roger J. Hajjar
  • Noncoding RNAs in heart failure / Seema Dangwal, Katharina Schimmel, Ariana Foinquinos, Ke Xiao, Thomas Thum
  • Cardiac myosin activation with gene therapy produces sustained inotropic effects and may treat heart failure with reduced ejection fraction / Sam L. Teichman, Kassandra S. Thomson, Michael Regnier.