Impact of survivin acetylation on its biological function

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhi...

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Bibliographic Details
Main Author: Dannheisig, David, (Author)
Format: eBook
Language: English
Published: Wiesbaden, Germany : Springer Spektrum, 2017.
Series: BestMasters.
Subjects:
Lysine.
Acetylation.
elektronické knihy
electronic books
ISBN: 9783658186234
9783658186227
Physical Description: 1 online resource (xxiii, 104 pages) : illustrations (some color)

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100 1 |a Dannheisig, David,  |e author. 
245 1 0 |a Impact of survivin acetylation on its biological function /  |c David Dannheisig. 
264 1 |a Wiesbaden, Germany :  |b Springer Spektrum,  |c 2017. 
300 |a 1 online resource (xxiii, 104 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a BestMasters 
504 |a Includes bibliographical references. 
505 0 |a Apoptosis -- The Programmed Suicide -- Cancer -- The Enemy Inside -- Nucleocytoplasmic Transport- Cellular Navigation -- Biological Function of Survivin -- Protein modification -- Make-Up for Proteins -- Cell cycle -- Virchow's Heritage. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. Contents Apoptosis - The Programmed Suicide Cancer - The Enemy Inside Nucleocytoplasmic Transport- Cellular Navigation Biological Function of Survivin Protein modification - Make-Up for Proteins Cell cycle - Virchow's Heritage Target Groups Lecturers, students and researchers in the biological-medical sector Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies The Author David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Lysine. 
650 0 |a Acetylation. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
776 0 8 |i Print version:  |a Dannheisig, David.  |t Impact of survivin acetylation on its biological function.  |d Wiesbaden, Germany : Springer Spektrum, 2017  |z 3658186224  |z 9783658186227  |w (OCoLC)988286437 
830 0 |a BestMasters. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-658-18623-4  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97365  |d 97365 

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