Endocannabinoids and lipid mediators in brain functions

• Other Authors: Melis, Miriam
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer, 2017.
• Subjects: Cannabinoids > Physiological effect.; Cannabinoids > Receptors.; Brain.; elektronické knihy; electronic books
• ISBN: 9783319573717; 9783319573694
• Physical Description: 1 online resource

The science of cannabinoids is 50 years old. These past years provided a remarkable and constant number of breakthroughs, showing that the signaling mediated by endocannabinoids and lipid mediators impacts almost every function of the body. Indeed, this represents a special field of research, which...

Table of Contents:

• Endocannabinoids and Lipid Mediators in Brain Functions; Contents; List of Committed Contributors; The Endocannabinoid System in Leptin-Driven Changes of Orexinergic Signaling Under Physiological and Pathological Conditions; 1 Endocannabinoids and Cannabinoid Receptor Type 1: An Overview; 2 Orexin/Hypocretin: Discovery and Characterization; 3 Orexin Receptors: Common Signaling with CB1; 4 Anatomical Overlap Between Cannabinoid and Orexin Receptor Distribution in the Brain; 5 Molecular Interactions Between Cannabinoid and Orexin Receptors.
• 6 Functional Interaction Between Cannabinoid and Orexin Receptors Under Leptin Signal Deficiency: Emerging Studies6.1 Appetite and Energy Homeostasis; 6.2 Reward, Arousal, and Seeking Behavior; 6.3 Sleep/Wakefulness; 6.4 Nociception; References; How CB1 Receptor Activity and Distribution Contribute to Make the Male and Female Brain Different Toward Cannabinoid-Induced E ... ; 1 Brain Sexual Dimorphisms and the Endocannabinoid System; 2 Sex-Dependent Effects of Cannabinoids; 3 CB1R Density and Function in the Male and Female Brain; 3.1 Prefrontal Cortex; 3.2 Thalamus; 3.3 Hypothalamus.
• 3.4 Hippocampus3.5 Amygdala; 3.6 Periaqueductal Gray; 3.7 Nucleus Accumbens; 3.8 Ventral Tegmental Area; 3.9 Cerebellum; 3.10 Basal Ganglia; 4 Hormonal Influence on CB1Rs; 5 Conclusions; References; Endocannabinoids, Stress, and Negative Affect; 1 Neuroendocrine Response to Stress; 2 Introduction to the Endocannabinoid System; 3 Role of the Endocannabinoid System in the Acute Effects of Stress; 4 Role of the ECB System in the Effects of Chronic Stress; 5 Stress-Related Negative Affect and Drug Withdrawal; 5.1 Stress-Related Negative Affective Behavior; 5.2 Drug Withdrawal.
• 5.3 Sex Differences in Negative Affect and Drug Withdrawal6 Implications for the Development of ECB-Based Therapeutics; 7 Summary; References; Cell-Autonomous Endocannabinoid Production Shapes Polarized and Dynamic Distribution and Signaling Patterns of Cannabinoid CB1 ... ; 1 Polarized Distribution of Neuronal Plasma Membrane Components; 2 GPCR Activation State Depends on the Plasma Membrane Environment; 3 The CB1 Cannabinoid Receptor: A Structurally Instable GPCR; 4 Ubiquitous Neuronal Membrane Component Endocannabinoids Produce Tonic CB1 Activation.
• 5 Subcellular Distribution of Neuronal CB1 Receptors6 Polarized CB1 Targeting in Neurons; 7 Polarized CB1R Signaling in Neurons; 8 A Special Case: CB1 at the Presynaptic Terminal; 9 Conclusion; References; Endocannabinoid-Dependent Synaptic Plasticity in the Striatum; 1 Introduction; 1.1 The Endocannabinoid System in the Striatum; 1.1.1 Striatal Neurons; 1.2 Endocannabinoid System Expression in the Striatum; 2 Cannabinoid Receptor-Mediated Regulation of Synaptic Transmission; 2.1 Effects of Cannabinoids on GABAergic and Glutamatergic Synaptic Transmission.