Safety and efficacy of gene-based therapeutics for inherited disorders

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and s...

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Bibliographic Details
Other Authors: Brunetti-Pierri, Nicola, (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, [2017]
Subjects:
Genetic disorders > Gene therapy.
Genetic transformation.
elektronické knihy
electronic books
ISBN: 9783319534572
9783319534558
Physical Description: 1 online resource

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024 7 |a 10.1007/978-3-319-53457-2  |2 doi 
035 |a (OCoLC)988029050  |z (OCoLC)988293074  |z (OCoLC)992502394  |z (OCoLC)992828185  |z (OCoLC)999515598  |z (OCoLC)1005802746  |z (OCoLC)1012043500  |z (OCoLC)1048174652  |z (OCoLC)1058324006  |z (OCoLC)1066616477  |z (OCoLC)1097100106  |z (OCoLC)1112530272 
245 0 0 |a Safety and efficacy of gene-based therapeutics for inherited disorders /  |c Nicola Brunetti-Pierri, editor. 
264 1 |a Cham, Switzerland :  |b Springer,  |c [2017] 
264 4 |c ©2017 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields. 
505 0 |a Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Genetic disorders  |x Gene therapy. 
650 0 |a Genetic transformation. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Brunetti-Pierri, Nicola,  |e editor. 
776 0 8 |i Printed edition:  |z 9783319534558 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-53457-2  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97326  |d 97326 
993 |x NEPOSILAT  |y EIZ 

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