Neuroepigenomics in aging and disease

• Other Authors: Delgado-Morales, Raul (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham, Switzerland : Springer, 2017.
• Series: Advances in experimental medicine and biology ; v. 978.
• Subjects: Neurogenetics.; Aging > Genetic aspects.; Genetic disorders.; elektronické knihy; electronic books
• ISBN: 9783319538891; 9783319538884
• ISSN: 0065-2598 ;
• Physical Description: 1 online resource

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the "physiological epigenome" are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have...

Table of Contents:

• Contributors; Part I: Neurodevelopmental and Childhood Disorders; 1: MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome; 1.1 Introduction; 1.2 MeCP2: The Protein; 1.3 DNA Methylation and MeCP2 Binding in the Brain; 1.4 MeCP2-Chromatin Binding; 1.5 Every Single Amino Acid Matters; 1.6 Teaming Up; 1.7 Higher-Order Chromatin Structures; 1.8 Neuronal Chromatin: Histone H1 and MeCP2; 1.9 Concluding Remarks; References; 2: The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome; 2.1 Introduction; 2.2 Rett Syndrome.
• 2.2.1 MeCP22.2.2 Rett Syndrome Models; 2.3 Rett Syndrome and ncRNAs; 2.3.1 ncRNAs and Therapies; 2.4 Conclusions and Future Perspectives; References; 3: Rubinstein-Taybi Syndrome and Epigenetic Alterations; 3.1 Introduction; 3.2 Genotype; 3.3 Clinical Phenotypes; 3.3.1 Epigenetic Mechanisms Underlying RSTS; 3.3.2 Testing the Biological Function of CBP in Rodents: Epigenetics and Memory; 3.3.3 Potential Therapeutic Applications of Histone Deacetylase Inhibitors for RSTS; References; 4: Epigenetics of Autism Spectrum Disorder.
• 4.1 Autism Spectrum Disorder (ASD) and Proposed Aetiologies4.2 Genetics of ASD; 4.3 Environmental Exposures and ASD Risk; 4.3.1 Exogenous Environment; 4.3.2 Endogenous Environment; 4.4 The Direct Role of Epigenetics in ASD; 4.4.1 Genetic Syndromes Involving Epigenes and ASD; 4.4.2 Direct Assessment of Epigenetic Marks in ASD; 4.5 Therapeutics; 4.6 Future Directions/Summary; References; Part II: Adolescence Brain Diseases; 5: Eating Disorders and Epigenetics; 5.1 Introduction; 5.2 Genetics of EDs; 5.3 Epigenetics and EDs; 5.4 Early Life Stresses.
• 5.5 Obstetric and Perinatal Complications5.6 Nutritional Factors and DNA Methylation; 5.7 Epigenetic Studies in ED Samples; 5.8 Conclusions and Future Directions; References; 6: Drug Addiction and DNA Modifications; 6.1 DNA Epigenetic Modifications; 6.2 Addiction; 6.3 Neuroepigenetics of Addiction; 6.3.1 Human Studies; 6.3.2 Animal Studies; 6.4 Multigenerational Effects of Drug Exposure; References; 7: Drug Addiction and Histone Code Alterations; 7.1 Introduction; 7.1.1 Epigenetics and Histone Code; 7.1.2 Histone Acetylation; 7.1.3 Histone Methylation.
• 7.1.4 Histone Phosphorylation7.1.5 Histone Ubiquitination and Sumoylation; 7.1.6 Other Modifications and Combinatorial Effects; 7.2 Histone Modifications and Addiction; 7.2.1 Histone Acetylation; 7.2.2 Histone Methylation; 7.2.3 Other Modifications; 7.3 Conclusions and Future Work; References; 8: Anxiety and Epigenetics; 8.1 Introduction; 8.2 The Neuroanatomy of Anxiety Disorders; 8.3 The Neuroendocrine Axis in Anxiety Disorders; 8.4 Epigenetic Factors; 8.5 Epigenetics in Animal Models of Anxiety; 8.6 Transgenerational Epigenetics.