Cellular injury in liver diseases

• Other Authors: Ding, Wen-Xing, Yin, Xiao-Ming
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer, 2017.
• Series: Cell death in biology and diseases.
• Subjects: Liver > Diseases > Molecular aspects.; Cell death.; elektronické knihy; electronic books
• ISBN: 9783319537740; 9783319537733
• Physical Description: 1 online resource

This comprehensive volume describes drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid-induced hepatocyte injury in addition to ischemia-reperfusion-mediated liver injury. The chapter authors who discuss these topics are leading experts on cell death in liver diseases. The autho...

Table of Contents:

• Series Preface; Preface; Contents; Contributors; Chapter 1: Cell Death in Drug-Induced Liver Injury; 1.1 Introduction; 1.2 Apoptosis in DILI; 1.2.1 FAS; 1.2.2 TRAIL; 1.2.3 Perforin/Granzyme; 1.2.4 TNF; 1.3 JNK in DILI; 1.4 Mitochondria in DILI; 1.5 ER Stress in DILI; 1.6 Regulated Necrosis DILI; 1.7 Autophagy in DILI; 1.8 Cell Death Biomarkers in DILI; 1.8.1 HMGB1; 1.8.2 Keratin 18 (K18); 1.8.3 miRNA; 1.9 Conclusion; References; Chapter 2: ER Stress in Drug-Induced Liver Injury; 2.1 Introduction; 2.2 ER Stress and the Unfolded Protein Response (UPR); 2.3 Drug-Induced Liver Injury (DILI).
• 2.4 HIV/AIDS and HIV PIs2.5 ER Stress and HIV PI-Induced Hepatotoxicity; 2.5.1 HIV PI-Induced Lipogenesis; 2.5.2 HIV PI-Induced Inflammation; 2.6 Summary; References; Chapter 3: Mechanisms of Acetaminophen-Induced Liver Injury; 3.1 Introduction; 3.2 Metabolism and Initiation of Toxicity; 3.3 The C-JUN-N-Terminal Kinase Pathway in APAP Toxicity; 3.4 The Role of the BCL-2 Protein Family in APAP Hepatotoxicity; 3.5 The Role of Receptor-Interacting Protein Kinase Family Members; 3.6 Oxidative and Nitrosative Stress in APAP Hepatotoxicity.
• 3.7 Mitochondria-Mediated DNA Fragmentation in APAP Toxicity3.8 Autophagy as an Adaptive Mechanism to APAP-Induced Cellular Stress; 3.9 The Sterile Inflammatory Response During APAP Hepatotoxicity; 3.10 Conclusions; References; Chapter 4: Cell Death and Liver Injuries in Hepatitis C Virus Infection; 4.1 Viral Hepatitis; 4.2 Hepatitis C Virus; 4.2.1 Hepatitis C Virus; 4.2.2 HCV Genome; 4.2.3 HCV Life Cycle; 4.3 Immune Evasion and Chronicity of HCV; 4.4 Cell Death and Liver Injury in Chronic HCV Infection; 4.4.1 Apoptosis: Implications in Inflammation.
• 4.4.2 Reactive Oxygen Species: Implications in Hepatic Cell Death and Tumorigenesis4.4.3 Autophagy: Implications in Cell Survival and Cancer; 4.4.4 Lipid Metabolism: Implications in Steatosis; 4.5 Conclusion and Future Perspective; References; Chapter 5: Hepatocyte Lethal and Nonlethal Lipotoxic Injury; 5.1 Introduction; 5.2 Lethal Hepatocyte Injury by Lipoapoptosis; 5.3 Lipoapoptosis and Liver Injury; 5.4 Nonlethal Hepatocyte Injury; 5.5 Conclusion; References; Chapter 6: Cell Death in Alcohol-Induced Liver Injury; 6.1 Introduction; 6.2 Alcohol Metabolism and Oxidative Stress.
• 6.3 Apoptosis, Necrosis, and Necroptosis in ALD6.4 Mechanisms of Alcohol-Induced Apoptosis in Hepatocytes; 6.5 Activation of Mitochondrial (Intrinsic) Apoptotic Pathway by Alcohol; 6.6 Activation of Death Receptor (Extrinsic) Apoptotic Pathway by Alcohol; 6.7 Necrosis and Necroptosis in ALD; 6.8 Other Forms of Regulated Programmed Cell Death in ALD; 6.8.1 Pyroptosis; 6.8.2 Ferroptosis; 6.9 Autophagy and Cell Death in ALD; 6.10 Concluding Remarks and Future Perspective; References; Chapter 7: Bile Acid-Induced Liver Injury in Cholestasis; 7.1 Introduction; 7.2 Bile Acid Biology.